Objective The aim of this study was to describe the outcome of a case series of fetuses with omphalocele.
Methods Ninety fetuses with omphalocele at the National
Objective Despite the relatively common occurrence of imperforate anus, prenatal diagnosis is rarely reported. In this study, we investigated the presence and diagnosis of imperforate anus along with strategies for improving prenatal diagnosis of the condition.
Patients and methods Fetuses and infants with imper
The present study indicates that duodenal obstruction is a more serious condition than previously believed, with an increased risk of prenatal asphyxia and death, even when the karyotype is normal and no associated anomalies are present. We consider the possibility that it could be caused by bradycardia/asystole following vagal overactivity due to distension of the upper gastrointestinal tract.
Objectives: We studied the rate of chromosomal cytogenetic abnormalities of fetuses with abnormal sonographic findings detected in the late second or third trimester. Methods: Retrospective analysis of all women at or beyond 23 gestational weeks at a single medical centre, who underwent amniocentesis during January 2012 to December 2015, indicated for abnormal sonographic findings that first appeared and were diagnosed at late second or third trimester. Primary endpoints were the results of fetal karyotype and chromosomal microarray analysis (CMA). Results: 102 women with 103 fetuses underwent amniocentesis due to late onset abnormal sonographic findings. All fetuses had a normal karyotype. Ninety-five women also had CMA performed. The detection rate of abnormal CMA (5/95, 5.3%) was similar to that of women who underwent amniocentesis due to abnormal early onset ultrasound findings detected at routine prenatal screening tests during the 1st or early 2nd trimester (7.3%, p=.46) and significantly higher than that for women who performed amniocentesis and CMA upon request, without having any fetal abnormal sonographic findings or medical indication for CMA (0.99%, p<.0001). Conclusions: Late onset sonographic findings are an indication for amniocentesis. We suggest that if amniocentesis is performed, CMA should be applied to evaluate fetuses with late onset abnormal sonographic findings. Objectives: To assess the value of genetic testing and morphological examination in a cohort of patients with gastroschisis.
ARED in the aortic isthmus appears to be an early sign of blood flow redistribution in this group of fetuses. Maternal oxygenation results in velocity waveform changes that suggest an increase of cerebral vascular resistance and a redistribution of blood from the brain to the vascular beds supplied by the descending aorta. The aortic isthmus is a suitable site to verify this response.
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