With the increasing demand in agriculture it has become important for us to increase the productivity by using various fertilizers insecticides Pesticides .But with the tremendous use of these products the soil has been affected badly because of the depletion in the essential minerals of the soil. So to overcome this problem it has become important for all of us touse a different remedy for the production of various biofertilizers. The production if such biofertilizers from various microorganisms was studied from this work.
Abstract-New drug target discovery is currently very popular with a great potential for advancing biomedical research and chemical genomics. Drug discovery is the process of discovering and designing drugs that includes target identification, target validation, lead identification, lead optimization and introduction of the new drugs to the public. G protein-coupled receptors are one of the most important drug targets. In the current scenario of drug research, approximately 60% of drug target molecules are located at the cell surface, and half of them are GPCRs. Fragment-based drug discovery is established as an alternative approach to high-throughput screening for generating novel small molecule drug candidates. Nanotechnology-based drug delivery systems have seen recent popularity due to their favorable physical, chemical, and biological properties, and great efforts have been made to target nanoDDSs to specific cellular receptors. Protein-protein interactions regulate a wide variety of important cellular pathways, and therefore represent a highly populated class of targets for drug discovery. An analysis of individual proteinprotein interaction systems has recently yielded success in the discovery of drug-like inhibitors.
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