We believe that both testicular torsion and detorsion result in testicular tissue damage by means of lipid peroxidation, which is evident by an increase in the tissue levels of MDA. Dietary supplementation with GE seems to attenuate the generation of toxic free radicals, as evidenced indirectly by low tissue MDA levels.
Aim:To investigate the effects of ingesting Fructus vitis minuta (black grape) on plasma and erythrocyte antioxidant parameters in elderly subjects. Materials and methods:Thirteen subjects (mean age 74.67 ± 0.58) participated in the study. They consumed 1 g/kg body weight per day of dried black Maraş grapes for 1 month. Before and after these periods, fasting blood samples were obtained, and oxidant (as MDA) and antioxidant (as SOD) parameters were studied in erythrocytes. Also, plasma samples were obtained from the subjects. Results:In the erythrocyte hemolysate, MDA (malondialdehydes) levels and SOD (superoxide dismutase) activities were found to be lower (P < 0.01) in the second samples compared to the first ones. Conclusion:We think that because free radical production was decreased SOD activities were not increased. Our results show that reduced peroxidation processes caused by Maraş grape consumption suggest that grape consumption has beneficial effects in elderly subjects. Key words: Black grape, elderly subjects Yaşlılarda kurutulmuş siyah üzüm tüketiminin plazma ve eritrosit antioksidan parametreler üzerine etkisiAmaç: Bu çalışmada yaşlılarda kurutulmuş siyah üzüm tüketiminin plazma ve eritrosit antioksidan parametreler üzerine etkisi incelendi.Yöntem ve gereç: Çalışmaya 13 kişi (ortalama yaşları 74,67 ± 0,58) katıldı. Katılımcılar 1 ay boyunca 1 g/kg vücut ağırlığı/gün kurutulmuş siyah üzüm tükettiler. Bu periyottan önce ve sonra katılımcıların eritrosit ve plazmalarından açlık kan örnekleri alındı ve oksidan (MDA gibi) ile antioksidan (SOD gibi) belirteçleri çalışıldı. Bulgular:Eritrosit hemolizatında MDA ve SOD değerleri ikinci örneklerde birincilere göre daha düşük bulundu. Biz serbest radikal üretimi artmadığı için SOD aktivitesinin artmadığını düşünmekteyiz.Sonuç: Maraş üzümü tüketiminden dolayı peroksidasyon olaylarının azalması, üzüm tüketiminin yaşlılarda yararlı bir etkiye sahip olabileceğini göstermektedir.
In this study, acute effects of two different types of cigarette smoking on plasma oxidant/antioxidant status were investigated. For this purpose, malondialdehyde (MDA) levels and antioxidant potential (AOP) values were measured in the plasma samples before and after cigarette smoking at fasting. After the first blood sample was obtained, second and third samples were withdrawn at 1.5 h and 3 h. In the first group, subjects smoked five cigarettes with full flavor (FF), and in the second group, five cigarettes with full-flavor low tar (FFLT). Quality classification is made mainly on the basis of tar content of the products. The cigarette with 23 mg tar is defined as FF and that with 12 mg tar as FFLT. MDA level was found to be significantly increased in the 1.5-h plasma samples of both groups, but the increase was greater in the FF group. AOP values, however, were found to be lower in the 3-h plasma samples of both groups, but the decrease was greater in the FF group compared with the FFLT group. It appears that acute smoking causes oxidant stress in blood plasma once exposed to smoke, and then this effect (MDA) begins to decrease. On the other hand, AOP is lowered due to oxidant stress created by smoke. With regard to the types of cigarettes, the FF product seems to be more oxidant than the FFLT product. Our results suggest that antioxidant supplementation might be beneficial for the smokers to cope with the oxidant load derived from cigarette smoke. It is also clearly seen from these results that cigarette manufacturers should reduce tar/nicotine ratio in their products in order to lessen the toxic effects of smoking without causing increased need to smoke.
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