Effects of grape consumption on plasma and erythrocyte antioxidant parameters in elderly subjects

Abstract

Aim:To investigate the effects of ingesting Fructus vitis minuta (black grape) on plasma and erythrocyte antioxidant parameters in elderly subjects. Materials and methods:Thirteen subjects (mean age 74.67 ± 0.58) participated in the study. They consumed 1 g/kg body weight per day of dried black Maraş grapes for 1 month. Before and after these periods, fasting blood samples were obtained, and oxidant (as MDA) and antioxidant (as SOD) parameters were studied in erythrocytes. Also, plasma samples were obtained from the subjects. Results:In the erythrocyte hemolysate, MDA (malondialdehydes) levels and SOD (superoxide dismutase) activities were found to be lower (P < 0.01) in the second samples compared to the first ones. Conclusion:We think that because free radical production was decreased SOD activities were not increased. Our results show that reduced peroxidation processes caused by Maraş grape consumption suggest that grape consumption has beneficial effects in elderly subjects. Key words: Black grape, elderly subjects Yaşlılarda kurutulmuş siyah üzüm tüketiminin plazma ve eritrosit antioksidan parametreler üzerine etkisiAmaç: Bu çalışmada yaşlılarda kurutulmuş siyah üzüm tüketiminin plazma ve eritrosit antioksidan parametreler üzerine etkisi incelendi.Yöntem ve gereç: Çalışmaya 13 kişi (ortalama yaşları 74,67 ± 0,58) katıldı. Katılımcılar 1 ay boyunca 1 g/kg vücut ağırlığı/gün kurutulmuş siyah üzüm tükettiler. Bu periyottan önce ve sonra katılımcıların eritrosit ve plazmalarından açlık kan örnekleri alındı ve oksidan (MDA gibi) ile antioksidan (SOD gibi) belirteçleri çalışıldı. Bulgular:Eritrosit hemolizatında MDA ve SOD değerleri ikinci örneklerde birincilere göre daha düşük bulundu. Biz serbest radikal üretimi artmadığı için SOD aktivitesinin artmadığını düşünmekteyiz.Sonuç: Maraş üzümü tüketiminden dolayı peroksidasyon olaylarının azalması, üzüm tüketiminin yaşlılarda yararlı bir etkiye sahip olabileceğini göstermektedir.

Protictive effects of green tea and garlic on the morphological and oxidative stress changes of hippocampus in aged male and female albino rats

“…group. This result conform the result of [37] who observed that phytochemical from plant-rich diets, including garlic, provide important additional protection against oxidant damage. Garlic extract supplementation improves blood lipid profile, strengthens blood antioxidant potential, and also leads to a decrease in the level of oxidation product (MDA) in the blood samples, which demonstrates reduced oxidation reactions in the body [38,39].…”

Protective roles of Cimin grape tissues on oxidative stress markers in the cellular system model

“…GSkM contains more catechin derivatives with gallyl moiety. The flavan-3-ol content and its correspondence with radical scavenging potency in the grape seed extracts were in accordance with the findings of other authors (27,28). However, Bozan et al (10) asserted that the higher antiradical activity of the extracts with lower C content may result from other flavonoid components of the extracts.…”

Mechanisms of Cardioprotective Effect of Aged Garlic Extract Against Doxorubicin-Induced Cardiotoxicity

“…[3][4][5][6] Various garlic preparations and components have also been shown to have antioxidant activity, including the ability to lower reactive oxygen species in vivo. [7][8][9] We recently reported that using a model of DOX-induced heart damage in rats, pretreatment with aged garlic extract (AGE), a strong antioxidant, offered protection against DOXinduced myocardial cell damage. 4 The present study was undertaken to investigate how AGE could protect the rat heart against DOX-induced cardiotoxicity and whether this interaction could be at the expense of antitumor activity of DOX.…”