Patients demonstrated positive (melancholy, anxiety, intellectual and motor inhibition) and negative affectation (apathy, dysphoria) accompanied by somatic/autonomic disorders, in particular, sleep deficiency. A marked therapeutic effect of ixel was shown in group 1. The number of patients with depression decreased significantly after treatment compared to group 2. Sleep improvement and increased motivation levels for recovery were observed as well.

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Background. Hippocampal sclerosis is one of the most common structural lesions associated with epilepsy. The standard medical care in the treatment of drug-resistant temporal lobe epilepsy associated with hippocampal sclerosis is surgery with anterior temporal lobectomy. The extent of resection depends on the involvement of hippocampal sclerosis in the epileptic system. Objective. Determine the relationship between the involvement of the hippocampus in the epileptic system (on the basis of the results of intraoperative electrocorticography (ECoG)) and the presence of structural changes in it, found on the basis of MRI data. Materials and methods. The present article presents an original retrospective study of the dependence of the signs of hippocampal sclerosis according to neuroimaging data and the formation of epileptiform activity in 36 patients treated at the Polenov Neurosurgical Institute — branch of Almazov National Medical Research Centre in 2015–2018. Results. Depending on the presence of hippocampal sclerosis and epileptiform activity, patients were divided into 4 groups: 1) patients with the presence of both hippocampal sclerosis and epileptiform activity in the mesiobasal structures (n = 15); 2) patients with identified sclerosis of the hippocampus, without registration of specific activity according to the results of ECoG (n = 8); 3) patients with epileptiform activity, while MR-negative (n = 10); 4) patients without epileptiform activity and without signs of hippocampal sclerosis according to MRI (n = 3). After a statistical check of the distribution of patients, it was found that the distribution was random. Conclusion. The fact of the presence of structural changes in the hippocampus could not be a pathognomonic sign of the inclusion of the hippocampal-entorial complex in the epileptic system.

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The results contained own data on the pathogenesis, clinical manifestations and treatment of dorsopathies in connective tissue dysplasias. Inclusion of long-acting pentoxifylline (vasonite) in the combined therapy in patients with dorsopathy associated with connective tissue dysplasia had a positive effect on disease course, decreased pain intensity and improved life activities.

Background. The basis of pre-surgical neurophysiological examinations of patients with pharmaco-resistant structural epilepsy is the method of monitoring bioelectrical activity of the brain, video-electroencephalographic monitoring and, if indicated, long-term invasive monitoring.Objective. The goal of the study is to estimate the diagnostic efficacy of the methods used for monitoring of the brain bioelectric activity on the basis of longterm results of surgical treatment of patients with temporal structural pharmaco-resistant epilepsy.Design and methods. The study included 61 patients with temporal lobe pharmaco-resistant epilepsy, who were divided into two groups: performance of video-EEG monitoring only (33 patients) and the additional use of invasive monitoring for the localization of the epileptogenic zone (28 patients). Each group was divided into subgroups depending on the outcome of surgical treatment: patients, in whom seizures ceased (Engel 1) and patients in whom seizures persisted to some degree (Engel 2-3-4). Invasive monitoring with ictal event recording was chosen as the reference method to calculate diagnostic efficacy.Results. Invasive monitoring was performed as part of the pre-surgical evaluation of patients with temporal lobe pharmaco-resistant epilepsy with a higher sensitivity (72.7 %) and accuracy (82.4 %) than video-EEG monitoring (sensitivity 50 %, accuracy 45.9 %).Conclusion. In simple monofocal variants of structural epilepsy, video-EEG monitoring has a sufficient level of diagnostic efficiency. The phenomenon of neurophysiological phenotypes convergence is responsible for the reduced diagnostic efficacy of noninvasive and invasive monitoring.