P339 Long-term electrocorticographic monitoring and pathological high-frequency oscillations in tumor-related epilepsy

Arkhipova, Nastasia; Alexandrov, Mikhail V.; Chukhlovin, A. A.; Pavlovskaya, Marina E.; Kostenko, Irina

doi:10.1016/j.clinph.2017.07.347

Cited by 1 publication

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“…Регистрация биоэлектрической активности коры мозга проводилась на аппаратно-программном комплексе «Мицар-ЭЭГ-202» ООО «Мицар» (Санкт-Петербург) с полосой пропускания от 0,3 до 500 Гц. Анализ высокочастотного компонента ЭКоГ выполнялся при помощи программного обеспечения Data Studio ООО «Мицар» (Санкт-Петербург) с параметрами фильтрации для диапазонов частот 80-250 и 250-500 Гц, чувствительностью 10-20 мкВ/см, разверткой 240 мм/с [1,5].…”

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Analysis of decreased bioelectric activity of a brain with pharmacoresistant epilepsy

Arkhipova¹,

Ulitin²,

Alexandrov³

2018

Bulletin of the Russian Military Medical Academy

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High-frequency bioelectrical activity in pharmacoresistant epilepsy is analyzed. It has been established that pathologic high-frequency oscillations are a potential marker of the epileptogenic zone. We propose a classification of pathological high-frequency oscillations: 1) continuous high-frequency oscillations; 2) modulated pathological high-frequency oscillations, associated with slow waves; 3) modulated pathological high-frequency oscillations, associated with spikes. An example illustrating the application of the analysis of high-frequency bioelectrical activity for the localization of the epileptogenic zone in the widespread irritative zone is given. Variants of interrelation of the regions generating pathological high-frequency activity and epileptic activity in the range up to 70 Hz are demonstrated. Recording of epileptic activity in the frequency range up to 70 Hz is not an exclusive criterion of the epileptogenesis. Recording of modulated pathological high- frequency oscillations associated with spikes allows the differentiation of two spike types. We can assume that the mechanism for generating spikes containing high-frequency component differs from the one for plain spikes. The generators of the pathological high-frequency oscillations are characterized by a smaller size, which should allow more precise localization of the focus of pathological activity. In some cases, the analysis of the high-frequency component of the electrocorticogram makes it possible to differentiate the secondary irritative zone. It has been demonstrated that in patients with extratemporal, especially frontal, epileptogenic zone localization pathological high-frequency oscillations provide additional information about the location of the generator of abnormal activity.

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