Disabilities as a result of musculoskeletal disorders increased by 45% from 1990 to 2010. Furthermore, OA is listed by the World Health Organization as the fastest increasing major health condition and ranked as the 2nd leading cause of disability [3]. OA is the underlying cause for more than 90% of the increasing number of total hip or knee joint replacement operations worldwide [4]. Studies from Africa show the prevalence of OA in South Africa is over 29.5% while that of Nigeria is 0.4% [5]. The Community Oriented Program for Control of Rheumatic Diseases (COPCORD) studies in Asia show the prevalence of OA is as high as 34% among people in the 60-64 years age bracket [6]. In the United States, the prevalence of OA increased from 6.6% in 1999 to 14.3% in 2014 [7]. However, in the same time-period, in the United States, the prevalence of rheumatoid arthritis (RA) reduced from 5.9% to 3.8% [7]. Rheumatoid arthritis is the 2nd highest attributable disease to global disability [8]. It has a twofold morbidity among women compared to men [9]. And it has been estimated that China had
The objectives of this study were to describe the clinicopathologic features and treatment outcomes of childhood rhabdomyosarcoma in a resource-constrained setting. All cases of childhood rhabdomyosarcoma seen over a 10-year period (July 2006 to June 2016) at the University College Hospital, Ibadan, Nigeria were reviewed. Data were extracted from the database of the pediatric Hematology/Oncology Unit of the hospital and analyzed. Ethical approval was obtained from the Institutional Ethics Committee. Fifty children were seen comprising 30 men and 20 women with bimodal ages of 4 and 5 years. Median duration of illness was 16 weeks and the most common primary tumor site was the head-and-neck region in 27 (54%) of cases. The histologic subtypes were embryonal in 30 (60%), alveolar in 9 (18%), and not specified in 11 (22%). The Intergroup Rhabdomyosarcoma Study group TNM Pretreatment stages were stage I in 15 (30%), stage III in 17 (34%), and stage IV in 18 (36%). Treatment included chemotherapy, surgery, and radiotherapy and abandoned in 20 (40%) cases. Median survival was 45 weeks (95% confidence interval: 16.4-73.6) and 5 (10%) patients were alive and disease free, 4 years or more after diagnosis. Outcome of childhood rhabdomyosarcoma is poor and early diagnosis and improved access to treatment are recommended.
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