Keloid and Hypertrophic Scars: A Review of Recent Developments In Pathogenesis And Management

Mofikoya, Bolaji O; Adeyemo, Wasiu Lanre; Abdus-Salam, A A

doi:10.4314/nqjhm.v17i4.12693

Cited by 37 publications

(42 citation statements)

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“…If the scar is confined to the margins of the original wound, it is called a hypertrophic scar [11].…”

Section: Discussionmentioning

confidence: 99%

Unusually Located Keloids - The Role of Cultural Practices in its Etiology

Tat¹,

Irekpita²

2011

J Clin Exp Dermatol

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Keloids are an exuberant growth of scar tissue extending beyond the boundaries of the original wound causing it and are mainly due to excessive collagen tissue synthesis. They have predilection for certain sites in the human body.There is an increasing trend for the location of such keloidal scars in parts of the body where they are not supposed to be.Certain cultural practices are responsible for this situation particularly in the African context. One of such practice that leads to this type of unusual complication is presented below and the pathogenesis as well as other aspects of keloidal growth are reviewed in general. Figure 1: Below is also another perfectly healed scar done while the patient was young. Healing here is similar to the figure above. However, note the discolouration (? bluish hue) of the scars with its cosmetic effect! In some tribes, this is the reason for this practice. Unusually Located Keloids-The Role of Cultural Practices in its Etiology Journal of Clinical & Experimental Dermatology Research

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“…If the scar is confined to the margins of the original wound, it is called a hypertrophic scar [11].…”

Section: Discussionmentioning

confidence: 99%

Unusually Located Keloids - The Role of Cultural Practices in its Etiology

Tat¹,

Irekpita²

2011

J Clin Exp Dermatol

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“…They reported that surgical excision with post-operative topical steroid injection had low recurrence rates [11]. Sternotomy incisions are relatively immobile and skin closure is free from tension.…”

Section: Discussionmentioning

confidence: 99%

Presentation and management of keloid scarring following median sternotomy: a case study

Patel

Papaspyros

Javangula

et al. 2010

J Cardiothorac Surg

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IntroductionKeloid scars following median sternotomy are rare and occur more frequently in pigmented skin. Different management strategies have been described with variable success. We present a case of keloid scar formation following cardiac surgery including our management and the final aesthetic result.Case descriptionA 64 year old female of fair complexion underwent mitral valve replacement. The procedure and postoperative recovery were uncomplicated, however, during the following year, thick keloid scars formed over the incision sites. Initial non surgical measures failed to relieve pain and did not offer any tangible aesthetic benefit. Eventually surgical excision was attempted. She presented to our clinic for nine months follow up with significant improvement in pain and aesthetic result.Discussion and EvaluationSeveral theories have attempted to explore the pathophysiology of keloid scar formation. A number of predisposing factors have been documented however none existed in this case. A variety of invasive and non invasive approaches have been described but significant differences in success rates and methodology of investigations still precludes a standardized management protocol.ConclusionsIn this case study a rare presentation of keloid scar has been presented. The variety of methods used to improve pain and aesthetic result demonstrates the propensity of keloid scars to recur and the therapeutic challenges that surgeons have to face in their quest for a satisfactory patient outcome.

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“…Previous studies (2) have demonstrated that the pathogenesis of KD is associated with the functional activity of multiple signaling transduction pathways, genes and cytokines. Fibroblasts are the primary effector cells of KD tissue, the typical pathological features of which include excessive proliferation, disordered apoptosis and secretion of large amounts of extracellular matrix (3).…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA H19 promotes the proliferation of fibroblasts in keloid scarring

et al. 2016

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Abstract. The expression of the long non-coding RNA (lncRNA) H19 is associated with proliferation in tumors. In order to investigate whether H19 may additionally mediate the proliferation of fibroblasts in human keloid disease, the present study collected samples from 24 subjects, including 8 with keloids, 8 with normal scars and 8 normal skin controls. Reverse transcription-polymerase chain reaction revealed that H19 levels were markedly increased in human keloids compared with normal scars and normal skin controls (P=0.017). In order to identify a potential role for H19 in the proliferative activity of human keloid fibroblasts, small interfering (si)RNA-mediated silencing experiments were performed. H19 siRNA treatment markedly inhibited the proliferation of keloid fibroblasts, as assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (P= 0.008). In order to identify the signaling mediators that are regulated by H19 in keloid fibroblasts, the expression levels of mammalian target of rapamycin (mTOR) and vascular endothelial growth factor (VEGF) were examined using western blotting. The results confirmed that knockdown of H19 inhibited mTOR and VEGF expression. In summary, the results indicate that H19 may be associated with increased proliferative activity of keloid fibroblasts, which may be mediated by mTOR and VEGF.

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Keloid and Hypertrophic Scars: A Review of Recent Developments In Pathogenesis And Management

Cited by 37 publications

References 0 publications

Unusually Located Keloids - The Role of Cultural Practices in its Etiology

Unusually Located Keloids - The Role of Cultural Practices in its Etiology

Presentation and management of keloid scarring following median sternotomy: a case study

Long non-coding RNA H19 promotes the proliferation of fibroblasts in keloid scarring

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