Электростимуляция Дермальных Фибробластов Человека На Электропроводящей Матрице

Kolbe, K. A.; Shishov, M. A.; Сапурина, И.Ю.; Смирнова, Н. В.; Kodolova-Chukhontseva, V. V.; Дресвянина, Е.Н.; Kamalov, Almaz; Юдин, В.Е.

doi:10.21883/jtf.2021.12.51772.160-21

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Журнал Технической Физики

2021

DOI: 10.21883/jtf.2021.12.51772.160-21

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Электростимуляция Дермальных Фибробластов Человека На Электропроводящей Матрице

K. A. Kolbe¹,

M. A. Shishov²,

И.Ю. Сапурина³

et al.

Abstract: Conducting composite based on biocompatible chitosan and single wall carbon nanotubes was used as a matrix for electrical stimulation of human fibroblasts. Parameters of ionic and electronic currents passing through the matrix upon applying cyclic potentials (±100 mV) were studied; the scaffold demonstrated high stability in the course of prolonged electric cycling. It was shown that preliminary electrical stimulation facilitated proliferative activity of human dermal fibroblasts in comparison to that of intac… Show more

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Cited by 2 publications

References 25 publications

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Electroconductive Materials Based on Polylactide and Polypyrrole for Biomedical Applications

Zavrazhnykh,

Sapurina,

Shishov

et al. 2023

Polymer Science, Series A

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Electroconductive scaffolds of different shape for tissue engineering have been obtained on the basis of two biocompatible polymers: polylactide and polypyrrole. The composite scaffolds have been based on porous permeable films or tubes of polylactides prepared via electrospinning. A layer of electroconductive polypyrrole has been applied at the developed surface of the scaffolds consisting of the chaotically interwoven fibers of micron-scale thickness. The structure of the tissue engineering scaffolds as well as their mechanical, redox, and electroconductive properties have been investigated. It has been found that the scaffolds are stable during electrical stimulation via prolonged application of the cyclic potentials.

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Electroconductive Materials Based on Polylactide and Polypyrrole for Biomedical Applications

Zavrazhnykh,

Sapurina,

Shishov

et al. 2023

Polymer Science, Series A

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show abstract

Influence of Electric Field on Proliferation Activity of Human Dermal Fibroblasts

Kamalov

Shishov

Смирнова

et al. 2022

JFB

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In this work, an electrically conductive composite based on thermoplastic polyimide and graphene was obtained and used as a bioelectrode for electrical stimulation of human dermal fibroblasts. The values of the electrical conductivity of the obtained composite films varied from 10−15 to 102 S/m with increasing graphene content (from 0 to 5.0 wt.%). The characteristics of ionic and electronic currents flowing through the matrix with the superposition of cyclic potentials ± 100 mV were studied. The high stability of the composite was established during prolonged cycling (130 h) in an electric field with a frequency of 0.016 Hz. It was established that the composite films based on polyimide and graphene have good biocompatibility and are not toxic to fibroblast cells. It was shown that preliminary electrical stimulation increases the proliferative activity of human dermal fibroblasts in comparison with intact cells. It is revealed that an electric field with a strength E = 0.02–0.04 V/m applied to the polyimide films containing 0.5–3.0 wt.% of the graphene nanoparticles activates cellular processes (adhesion, proliferation).

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Электростимуляция Дермальных Фибробластов Человека На Электропроводящей Матрице

Cited by 2 publications

References 25 publications

Electroconductive Materials Based on Polylactide and Polypyrrole for Biomedical Applications

Electroconductive Materials Based on Polylactide and Polypyrrole for Biomedical Applications

Influence of Electric Field on Proliferation Activity of Human Dermal Fibroblasts

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