Фармако–токсикологічна Оцінка Препарату «цифлур»

Nagorna, L.

doi:10.15421/nvlvet7149

Cited by 2 publications

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“…Варто зазначити, що комахи належать до категорії найбільш небезпечних біологічних агентів і є найчисельнішим за видовим різноманіттям класом тварин. Завдяки своїй надзвичайній лабільності й здатності пристосовуватися до умов середовища, які швидко змінюються, популяції комах, які паразитують на продуктивних тваринах, постійно зростають (Kutsan & Ponomarenko, 2003;Abramov et al, 2013;Nagorna, 2016). Нерідко членистоногі є ос-новними провокаційними чинниками спалахів бактеріозів та віроозів у господарствах.…”

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Pharmaco-toxicological properties of the drug “Ciflur” as a preventive agent for nodular dermatitis

et al. 2020

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The article presents data study of acute toxicity of the drug “Ciflur”. Nodular dermatitis causes significant economic losses due to a temporary decrease in milk productivity, temporary or permanent sterility of breeding bulls, skin lesions, and death of sick animals due to secondary infections. Specific treatments have not been developed. Preventive disinsection of livestock premises is effective for prevention. For this purpose, a new drug “Сiflur” was developed. 1 ml of the drug contains the active substance: cyfluthrin – 10.0 mg. Toxicity studies of the drug and evaluation of the results were performed in accordance with standard methods. The study of acute toxicity of the drug “Сiflur” when applied to the skin was performed on 18 white rats weighing 170–190 g. The animals were divided into 3 groups of 6 heads. Rats were kept in the vivarium in accordance with sanitary rules and on a standard diet adopted in the vivarium with the use of compound feed. The first group of rats on the skin was applied the drug “Сiflur” at a dose of 1250 mg/kg, the second – 2500 mg/kg body weight. The third group of rats was a control – these animals on the skin was applied Solveso 200 solvent in the amount of 2500 mg/kg body weight. Acute toxicity of the drug was studied when applying the drug to a pre-cut area of skin on the back, which was at least 10 % of the total surface area of the animal. In order to prevent excessive spreading on the skin, the drug was applied slowly, drying with warm air with a hair dryer. For 14 days after cutaneous application of the drug was recorded daily its effect on the survival of rats, the appearance of rats and manifestations of physiological disorders of animals. Rats were weighed before application, as well as 3, 7 and 14 days after the start of the study. After 14 days, an autopsy was performed and the condition of the internal organs was examined for possible impressions, and the internal organs were weighed and their relative weight coefficients were calculated. Therefore, a single skin application of “Ciflur” at doses of 1250 and 2500 mg/kg body weight did not result in the death of experimental rats. The acute LD50 of the drug “Сiflur”when applied to the skin exceeds 2500 mg/kg body weight, which allows it to be classified as hazard class 4 according to the International Standard GOST 12.1.007-76, or category 5 according to the International Global Classification of Harmonized System (GHS). Only the application of “Ciflur” at the highest dose (2500 mg/kg body weight) caused a slight short-term reddening of the skin in some experimental rats, which disappeared without intervention for 4–8 hours.

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Pharmaco-toxicological properties of the drug “Ciflur” as a preventive agent for nodular dermatitis

et al. 2020

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Research of acute toxicity, allergizing and local-irritative action of the veterinary drug “Yodozol”

Сачук

Zhyhalyuk

Lukyanik

et al. 2019

Veterinary Medicine: Inter-Departmental Subject Scientific Collection

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The purpose of the work was to determine, in experiments on rodents, the parameters of acute toxicity, allergenic and locally irritative effects of iodine-containing uterine drug for the treatment and prevention of intrauterine infections of animals. Materials and methods. Preclinical studies of acute toxicity of “Yodosol” containing iodine and potassium iodide were performed on 90 white mice, 30 white outbred rats and 6 rabbits. Clinical, pharmacotoxicological and statistical methods were used. Results of work. It has been found that at intragastric administration in experimental rats and mice, DL50 values exceed 8,000 mg/kg body weight and have no effect on the behavioral responses and physiological parameters of laboratory animals. It has been investigated that “Yodosol” aerosol has no local toxic and irritant effects on the skin and mucous membranes of laboratory animals (rabbits). Conclusions. The use of the drug «Yodosol», in doses above 8,000 mg/kg body weight, does not affect the behavioral responses and physiological parameters of laboratory animals. The drug has no local toxic and irritant effects on the skin and mucous membranes. According to the requirements of SOU 85.2-37-736:2011 and GOST 12.1.007-76, the newly developed drug “Yodosol” belongs to low-toxic substances — 4 toxicity classes

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Фармако–токсикологічна Оцінка Препарату «цифлур»

Abstract: 214Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.

Cited by 2 publications

References 1 publication

Pharmaco-toxicological properties of the drug “Ciflur” as a preventive agent for nodular dermatitis

Pharmaco-toxicological properties of the drug “Ciflur” as a preventive agent for nodular dermatitis

Research of acute toxicity, allergizing and local-irritative action of the veterinary drug “Yodozol”

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