Состояние Когнитивных Функций После Ангиореконструктивных Операций На Сонных Артериях

Танашян, М.М.; Медведев, Р.Б.; Лагода, О.В.; Berdnikovich, Elena Semenovna; Скрылев, С.И.; Гемджян, Э Г; Кротенкова, М.В.

doi:10.24075/vrgmu.2019.059

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Эхогенность и возможность прогнозировать состав каротидной АСБ (а также состав эмболического материала после КАС [19]) является общепризнанным показателем уязвимости бляшки [20]. Известны прогностически неблагоприятные факторы, провоцирующие рестеноз стентированной ВСА: сахарный диабет, ожирение, курение, контрлатеральный стеноз, артериальная гипертония и дислипидемия [21].…”

Section: следующим этапом корреляционного анализа была оценка изменен...unclassified

Assessment of Biomarker Profile in Patients Post Carotid Angioplasty and Stenting

Tanashyan

Annushkin

Raskurazhev

et al. 2023

Annals of Clinical and Experimental Neurology

View full text Add to dashboard Cite

Introduction. Cardiovascular diseases are predominantly caused by atherosclerosis as a multifactorial chronic condition. Alterations in the hematological system and the blood vessel wall are considered as highly significant for onset and development of cerebrovascular disorders associated with atherosclerosis. Biomarkers as measurable indicators are to verify abnormal activity. Objective: to assess atherogenesis biomarkers in patients after carotid angioplasty and stenting (CAS) as associated with development of cerebrovascular disease. Materials and methods. We evaluated 50 individuals (50% men, 50% women; average age 65.4 6.4 years) with established cerebrovascular disease associated with brain atherosclerosis. All of them had hemodynamically significant abnormalities in the internal carotid artery (ICA) with both symptomatic (stenosis 60% and more) and asymptomatic (stenosis 70% and more) stenoses confirmed by duplex scanning of the brachiocephalic arteries. All patients underwent CAS as indicated. Before and 1 year after the intervention, we performed clinical and neurological examinations, brain magnetic resonance imaging, and laboratory tests of atherogenesis biomarkers. Results. At baseline, all the individuals demonstrated a pro-atherogenic shift in the assessed indicators, predominantly markers of extracellular matrix degradation, inflammation and atherogenesis (including osteoprotegerin and chromogranin А). Additionally, we established a direct correlation between osteoprotegerin levels and the characteristics of mostly hyperechoic atherosclerotic plaques (r = 0.29; p 0.05). A year later, no signs of restenosis were shown in follow-up ultrasound assessment of stented arteries in any patient. In 1 year post CAS, we found significant changes in the levels of osteoprotegerin (decrease to 1.765 pg/mL [1.592; 1.937]; p 0.05) and chromogranin А (elevation to 31.3 g/L [13.9; 90.7]; p 0.05). Re-assessment demonstrated association between changes in the pattern of the nitrogen oxide system, which tends to improve (NO elevation to 38.23 mol/L [32.95; 43.51]; p 0.001), and atheroprotective shift in the morphology of atherosclerotic plaques and biomarker profile. Conclusion. Prospective, 1-year long observation for patients who underwent CAS for symptomatic/asymptomatic hemodynamically significant ICA stenoses revealed favourable atheroprotective shift in both ultrasound and hematological atherogenesis biomarker ratio. This shift contributed to the absence of cerebral atherosclerosis progression during the follow-up. The process may be mediated by chromogranin А and osteoprotegerin, and their further research is needed from perspective of atherogenesis.

show abstract

Section: следующим этапом корреляционного анализа была оценка изменен...unclassified

Assessment of Biomarker Profile in Patients Post Carotid Angioplasty and Stenting

Tanashyan

Annushkin

Raskurazhev

et al. 2023

Annals of Clinical and Experimental Neurology

View full text Add to dashboard Cite

show abstract

Cognitive function dynamics in comorbid patients after angioreconstructive interventions

Tanashyan

Антонова

Лагода

et al. 2020

RJTAO

View full text Add to dashboard Cite

Angioreconstructive interventions are generally known to be of prophylactic value for cerebrovascular diseases (CVD). At the same time, their prognosis in comorbid patients, particularly in those with type 2 diabetes (T2D), have been insufficiently covered.Objective: to study the impact of T2D on cognitive functions after carotid angioplasty with stenting (CAS)Patients and methods. CAS was performed in 99 patients with chronic CVD. Group 1 consisted of 51 patients (median age, 64.5 years) without carbohydrate metabolism disorders. Group 2 included 48 patients (median age, 64 years) with T2D. Over time, all the patients underwent clinical, neurological, and neuropsychological examinations, general clinical and biochemical blood tests, duplex scanning of the brachiocephalic arteries, and magnetic resonance imaging (MRI) of the brain. Blood flow in the middle cerebral artery was monitored to assess the embolic and hemodynamic situation during a CAS procedure.Results and discussion. The baseline frequency of neurocognitive impairment was almost the same (75%) in both groups; however, the impairment was more obvious in patients with T2D. Re-examination in Group 1 patients immediately after intervention revealed slight positive cognitive changes, while the patients with T2D showed a decrease in the indicators of mental functions. The improved ability to abstract and increase the level of generalization of functions appeared in T2D patients only 2 months after intervention. Post-CAS MRI revealed ipsilateral acute ischemic foci (AIF) in the brain substance in 11 (22%) patients of Group 1 and in 24 (50%) with concomitant T2D. Comparison of neuroimaging data with cognitive function assessments for the entire group of the examinees established deterioration in the cognitive status in patients with new ischemic brain changes detected after intervention.Conclusion. CVD concurrent with T2D usually contributes to deterioration in the cognitive status. Angioreconstructive interventions, in particular CAS, are frequently accompanied by the identification of AIF (including «silent» ones) that can cause a transient deterioration in cognitive functions. When planning angioreconstructive interventions in patients with T2D, the question arises of predicting such risks and possible neuroprotective methods.

show abstract

Состояние Когнитивных Функций После Ангиореконструктивных Операций На Сонных Артериях

Cited by 2 publications

References 0 publications

Assessment of Biomarker Profile in Patients Post Carotid Angioplasty and Stenting

Assessment of Biomarker Profile in Patients Post Carotid Angioplasty and Stenting

Cognitive function dynamics in comorbid patients after angioreconstructive interventions

Contact Info

Product

Resources

About