Растворимость Сверхкритического Диоксида Углерода В Полиэтиленгликоле-4000

Гильмутдинов, И. М.; Гильмутдинов, И. И.; Кузнецова, Инна; Сабирзянов, А. Н.

doi:10.7868/s0040364416010026

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методика исследования и установка1

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2021

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“…Для диспергирования лидокаина в настоящей работе используется установка RESS-100 (рис. 1) фирмы Thar Technologies Inc. (США, официальный дистрибьютор на территории Российской Федерации ЗАО " ШАГ") Методика проведения эксперимента описана в предыдущих работах и диссертации [1,2]. Рис.…”

Section: методика исследования и установкаunclassified

Улучшение Растворения Лидокаина Посредством Диспергирования Методом Быстрого Расширения Сверхкритического Раствора

Кузнецова¹,

Сандугей²,

Гильмутдинов³

et al. 2021

Журнал Технической Физики

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An experimental study of the grinding of lidocaine by the rapid expansion of supercritical solutions (RESS method) was carried out. The experiments were carried out in the pressure range of 10–35 MPa and temperatures of 308–333 K. The analysis of the morphology and size of particles, as well as the effect of the process parameters on them, was carried out. Qualitative and quantitative spectrophotometric analysis was carried out. The dissolution test was carried out in a phosphate buffered saline medium simulating plasma, which showed that the reduction in particle size gave an increased yield of the drug in a shorter period of time compared to the original drug that was not treated.

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Section: методика исследования и установкаunclassified