Місце Центральних Міорелаксантів У Лікуванні Неспецифічного Болю В Спині

Zaychenko, G. V.; Pliushch, S.I.; Sinitsyna, O. S.

doi:10.22141/2224-0713.4.98.2018.139427

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…Similar LC-ESI-MS method was reported by Jeoung et al for determination of Eperisone in human plasma using a solvent extraction technique and Tolperisone as internal standard. The limit of detection for analyte was found to be 0.1 pg/ml for Eperisone with a linear range from 0.01 to 10.0 ng/ml [9]. Ding et al also utilized the liquid extraction technique and similar The LOD was found to be 0.5 ng/ml with a linearity in the range of 1-500.0 ng/ml (r 2 = 0.999), for Eperisone, Tolperisone and Tizanidine.…”

Section: Discussionmentioning

confidence: 98%

“…Eperisone also possess some vasodilator activity and antinociceptive effects [5][6][7][8] . Although the use of centrally acting muscle relaxants is associated with undesirable side effects like drowsiness, dizziness and ataxia, but still they are widely prescribed alone or in combination with analgesics for the management of muscle spasms and myalgias, more commonly lower back pain [9][10][11][12] . Eperisone because of its mechanism of action, is comparatively devoid of the undesirable side which are usually associated with intake of centrally acting muscle relaxants 7,8,[13][14][15] .…”

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confidence: 99%

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Comparative pharmacokinetics of osmotic-controlled and immediate-release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method

Ahmed

Shoaib

Yousuf

et al. 2020

Sci Rep

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to evaluate and compare the pharmacokinetic (pK) characteristics of a newly developed oral osmotically controlled drug delivery system of Eperisone 150 mg tablets with Eperisone immediate release (iR) marketed tablet brand as a reference formulation. it was a single dose, two treatment, two sequence, randomized, crossover study, involving 12 healthy human subjects. A modified, sensitive Lc-eSi-MS/MS method was developed and validated as per fDA guidelines for estimation of eperisone in plasma using a simple extraction and quick protein precipitation method. non-compartmental pharmacokinetic model was used for pK analysis. Results were statistically compared using logarithmically transformed data, where p > 0.05 was considered as non-significant with 90% CI limit of 0.8-1.25. The bio-analytical method used for estimating drug plasma concentration was found to be simple, selective, linear, accurate and precise with 0.01 ng/ml as limit of detection. The comparative PK analysis revealed an insignificant difference in AUC 0-∞, AUC 0-t, V z /f, cl/f and t 1/2λz , whereas a significant difference in C max , t max and Mtts were found. the relative bioavailability of eperisone osmotic tablet was 109.7%. The osmotic controlled release drug formulation was found to release Eperisone for an extended period with less inter individual fluctuation in pharmacokinetic variables.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Comparative pharmacokinetics of osmotic-controlled and immediate-release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method

Ahmed

Shoaib

Yousuf

et al. 2020

Sci Rep

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Characteristics of Muscle Recovery under Experimental Post-Traumatic Contracture

Pankevych¹,

Matolych²,

Уштан³

et al. 2021

Ukr. ž. med. bìol. sportu

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The frequency of traumatic injuries of the maxillofacial area and the degree of their severity, have been increasing in recent years. The introduction of modern methods of treatment made it possible to improve the results of treatment and shorten its duration. Myogenic contractures develop as a complication after facial injuries, soft tissue injuries, in particular, masticatory muscles. The gastrocnemius muscle of a rat has the same striated structure as the pterygoideus medialis muscle of a person. The purpose of the work is to study the regeneration of striatal muscles with post-traumatic contractures on the basis of combined treatment of laboratory rats. Materials and methods. The study was carried out on 45 sexually mature 12 months old outbred white male rats, which weighed 180-200 g. In animals, reflex post-traumatic muscle contractures (traumatic myositis) resulting from the slaughter of calf muscles (without violating the integrity of muscle tissue) were simulated on the posterior left leg. The rats were divided into two groups. Group 1 included 21 animals that did not receive treatment and whose wounds healed by secondary intention. Group 2 included 24 rats that received combined treatment: on the 2nd day after surgery – general (oral) administration of the drug with the active substance cyclobenzaprine hydrochloride – 0.15 mg, once a day with daily procedures of magnetic laser therapy on the affected hind limb. Results and discussion. Depending on the signs of pain behavior (changes in behavior, restriction of movement, increased sensitivity, pain), the intensity of myogenic pain syndrome was assessed (low, moderate, high, very high). It was found that the use of combined treatment (magnetic laser therapy and the use of cyclobenzaprine hydrochloride) led to the normalization of behavioral and motor reactions by the 28th day: 56% of rats didn’t feel any pain and 44% had a low level of pain. The animals with the same trauma, which weren’t treated, showed a high and moderate level of pain. On the 28th day these animals could lean on their hind limbs while they were moving. However, they could not fully move due to a sharp restriction of their left hind limb function. The obtained results are the basis for the development of new approaches to improving the methods of prevention and rehabilitation treatment of contractures using magnetic laser therapy and central muscle relaxants. Conclusion. It was found that the use of magnetic laser therapy and cyclobenzaprine hydrochloride inhibited the development of an acute inflammatory reaction in the damaged muscle tissue of the hind limb of animals, accelerated and optimized reparative processes, which prevented excessive, functionally significant growth of connective tissue

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Місце Центральних Міорелаксантів У Лікуванні Неспецифічного Болю В Спині

Cited by 2 publications

References 10 publications

Comparative pharmacokinetics of osmotic-controlled and immediate-release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method

Comparative pharmacokinetics of osmotic-controlled and immediate-release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method

Characteristics of Muscle Recovery under Experimental Post-Traumatic Contracture

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