Механизмы Плейотропных Эффектов Статинов

Горбунов, Александр Анатольевич; Лемина, Елена Юрьевна

doi:10.30906/0869-2092-2020-83-8-42-46

Эксп. и клин. фармакол.

2020

DOI: 10.30906/0869-2092-2020-83-8-42-46

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Механизмы Плейотропных Эффектов Статинов

Александр Анатольевич Горбунов¹,

Елена Юрьевна Лемина²

Abstract: Изложены современные представления о механизмах плейотропных эффектов статинов на сердечно-сосудистую систему. Показана важная роль фермента Rho-киназы и механизмы угнетения ее активности статинами. Кроме того, описана роль изопреноидов в патогенезе развития атеросклероза и отражена значимость угнетения их образования статинами. Представленные процессы могут стать перспективной мишенью для создания препаратов, эффективных не только при лечении атеросклероза, но и ряда других патологических процессов.

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The atorvastatin effects on the prevention of contrast-induced acute kidney injury during computed tomography with contrast media

Васин

Mironova²,

Fоmin³

2022

Terapevticheskii arkhiv

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Aim. To assess the role of atorvastatin to the frequency of contrast-induced acute kidney injury (CI-AKI) in patients with cardiovascular diseases (CVD) undergoing computed tomography (CT) with intravenous contrast media. Materials and methods. One hundred patients with CVD undergoing CT with with intravenous contrast media administration were included in prospective observational study (ClinicalTrials.gov ID NCT04666389). Patients were divided into 3 groups 16 (15.8%) patients receiving atorvastatin at a dose of 80 mg 24 hours and 40 mg before the CT and 40 mg after; 33 (32.7%) patients 40 mg before the CT and 40 mg after; 52 (51.5%) people not receiving statin therapy. The primary endpoint was CI-AKI according to KDIGO criteria: the 25% rise (or 0.5 mg/dl) of serum creatinine from baseline assessed 4872 hours after administration of contrast media. There were 51% of men. The average age was 59.7714.4. The most frequent cardiovascular disease was hypertension 86%. Results. CI-AKI was diagnosed in 4 (3.96%) patients. At the same time, it was not possible to establish statistically significant relationships (p0.05) between risk factors and the development of CI-AKI. Statins can be a successful way to prevent this complication. Conclusion. Cardiovascular diseases may increase the risk of CI-AKI after computed tomography with intravenous contrast media administration. Therefore, it is recommended to evaluate the serum creatinine concentration in such patients.

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The atorvastatin effects on the prevention of contrast-induced acute kidney injury during computed tomography with contrast media

Васин

Mironova²,

Fоmin³

2022

Terapevticheskii arkhiv

View full text Add to dashboard Cite

show abstract

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Механизмы Плейотропных Эффектов Статинов

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The atorvastatin effects on the prevention of contrast-induced acute kidney injury during computed tomography with contrast media

The atorvastatin effects on the prevention of contrast-induced acute kidney injury during computed tomography with contrast media

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