Клінічні Прояви Гастроінтестинальної Форми Харчової Алергії У Дітей І Підходи До Її Діагностики

Chernysh, Yu.R.; Оkhotnikova, O.M.

doi:10.22141/2224-0551.12.5.2017.109280

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Sections were stained with hematoxylin and eosin. The number of eosinophils was calculated based on the threshold diagnostic criteria depending on the digestive tract segment, specified in the works of many researchers [11][12][13][14] in five random high-power fields (HPF), which is a morphological criterion of an allergic reaction. Microscopic examination of stained histological specimens was performed on a light microscope MICROmed XS-3320 (Ningero Sheng Heng Optics and Electronics Co.) with 100×, 200×, 400× magnification.…”

Section: Methodsmentioning

confidence: 99%

1

Bubyr¹,

Kryuchko²,

Несіна³

et al. 2021

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Background. In pediatric practice, increasing attention has been recently paid to the study of allergic disorders in various parts of the gastrointestinal tract, and a number of unresolved issues regarding the timely diagnosis and treatment of eosinophilic lesions of the digestive system determines the relevance of this topic. The purpose of the research was to study the endoscopic and morphological changes of the upper gastrointestinal tract in children with gastrointestinal symptoms of food hypersensitivity. Materials and methods. The study enrolled 34 children aged from 6 to 15 years with clinical signs of disorders of the upper digestive tract against the background of food hypersensitivity reactions. Depending on the level of total IgE, study participants were divided into two groups. The first group consisted of 18 children with IgE-independent allergic reactions to food (Me (Q1-Q3) 35.0 (28.0–77.5)). The second group included 16 patients with IgE-induced allergic manifestations of food hypersensitivity (Me (Q1-Q3) 240.5 (158.0–475.8)). To achieve the aim of the research, all children underwent fibroesophagogastroduodenoscopy with subsequent sampling and morphological evaluation of biopsy specimen. Results. According to the results of endoscopic examination of patients, the structure of lesions of the upper gastrointestinal tract depending on the predominance of IgE-independent or IgE-mediated gastrointestinal symptoms of food hypersensitivity did not have statistically significant differences. Morphological characteristics had some differences in the study groups and were represented by the prevalence of eosinophilic infiltration in children with IgE-induced food hypersensitivity reactions. Conclusions. The isolated gastric lesions prevailed in the endoscopic presentation of children with gastrointestinal manifestations of food allergy, and morphological signs of chronic gastritis are characterized by changes in the surface epithelium due to pronounced polymorphonuclear inflammatory infiltration in the lamina propria with a predominance of lymphocytes, neutrophils and plasma cells. The degree of activity of the eosinophilic inflammatory process was more pronounced in the group of children with IgE-induced food hypersensitivity reactions (r = 0.652; p < 0.01).

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Section: Methodsmentioning

confidence: 99%

1

Bubyr¹,

Kryuchko²,

Несіна³

et al. 2021

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Clinical peculiarities of gastrointestinal symptoms in children with food allergy

Karpushenko

Pavlenko

Voloshyn

2020

The Journal of v. N. Karazin Kharkiv National University, Series "Medicine"

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Introduction. Pediatric allergy problems are widely spread among children of almost all age groups. Number of cases with combined allergic a digestive disorders increases and study of gastrointestinal lesions in children with allergies became an urgent medical and social problem. It is based on the increasing frequency of both allergy and pathology of the digestive system, increasing severity of cases and necessity to analyze type of gastrointestinal disorder in children with allergy and correlation among it. Objective. To study the clinical features of gastrointestinal symptoms in children with food allergies. Materials and methods. 169 pediatric patients 3–17 years old were examined. The main group was of 105 children with food allergies, the control group – 64 children without allergies. Verification of food allergy and pathology of the digestive system was carried out in accordance with the current protocols. All patients had skin prick tests, provocative test, determination of specific IgE. All patients were divided into 3 groups by age: 1st – 3–6 years old, 2nd – 7–11 years old, 3rd – 12–17 years old. The results were processed by the methods of variation statistics. Results. Gastrointestinal manifestations were observed in children of all age groups (59 %, 65 %, 74 %). Skin manifestations predominated in the 1st and the 3rd group. Respiratory symptoms – in groups 2 and 3. A combination (more often of skin and gastrointestinal) manifestations was found in group 3. Pain syndrome in children of the main group was characterized by moderate intensity (55.2 %), more often not associated with food intake (45.7 %), localized in the umbilical region (58 %), less often in the epigastrium (23.4 %), in 15 % there was no pain. Dyspeptic syndrome was manifested by nausea (36.2 %), decreased appetite (25.7 %) and belching (17.1 %). Dyspeptic syndrome was absent in 34.3 % of patients. The manifestations of asthenovegetative syndrome were noted in 38.1 % of children in the main group. The correlation between the type of allergen and the reason of gastrointestinal symptoms has not been identified. Conclusions. A variety of clinical manifestations of food allergy has been proven in the form of skin, gastrointestinal, respiratory symptoms and their combination. Gastrointestinal symptoms indicate the presence of functional disorders of the digestive tract. With age, the variety of food allergens increases, without qualitatively affecting the nature of gastrointestinal symptoms.

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Клінічні Прояви Гастроінтестинальної Форми Харчової Алергії У Дітей І Підходи До Її Діагностики

Cited by 2 publications

References 45 publications

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1

Clinical peculiarities of gastrointestinal symptoms in children with food allergy

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