The article raises the urgent question of the organization and development of innovation centers in the subjects of the Russian Federation. Recently, a reduction in the share of industrial production and the emergence of an innovation infrastructure is characteristic of Russian cities, and has become a major component of the development of the economy of changing regions. Voronezh region is also the technologically developing territory. Like other Russian regions, Voronezh is interested in improving the speed, quality and coverage of service provision, in increasing the rate of change in service delivery processes, and in reducing public expenditures. The creation and development of an innovation cluster in the region can become a growth point for the economy of the Voronezh region. The article substantiates and describes the need for the creation and design concept of an innovation center in the Voronezh region. The results of the analysis of the introduction of innovative technologies and technologies of the “smart city” in various regions of Russia are presented. The main directions in creating an innovation center in the Voronezh region are highlighted. The necessary measures for inclusion in the project on digitalization of urban sectors of the new technological territory are considered. The work provides a comprehensive planning of development and use of the territory in accordance with the concept of "smart city". The expected effects and results from the placement and development of the innovation center in the region are given.