Диференційовані Методи Хірургічного Лікування Хворих З Наслідками Ушкоджень Лицевого Нерва

Цымбалюк, Ю В; Tretyak, Ihor B.; Gatskiy, Oleksandr; Luzan, Borys M.; Petriv, Taras; Цымбалюк, В. И.

doi:10.22141/1608-1706.6.20.2019.186034

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Ушкодження периферичних нервів виявляють у 77 % спостережень при травмі верхньої кінцівки, у 23 % нижньої, а під час військових дій цей показник складає 12 % [2]. У структурі травм опорно-рухового апарату, ушкодження периферичних нервів становить від 1,5 до 6 % [3,4].…”

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“…акад. А. П. Ромоданова НАМН України"; 2) Сумський державний університет МОН України; 3) ДНУ "Науково-практичний центр профілактичної та клінічної медицини" Державного управління справами; 4) ПВНЗ "Міжнародна академія екології та медицини" те, проблема відновлення периферичного нерва після його травматичного ушкодження ще не вирішена.…”

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Stem Cell Technology in Peripheral Nerve Restoration

Petriv

Tsymbalyuk

Potapov

et al. 2020

EUMJ

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Peripheral nerve injuries are a significant problem in the medical and socio-economic plan, as they are accompanied by a high incidence of disability by people of working age. In recent decades, significant progress has been made in the restorative surgery of the peripheral nervous system, in particular through the introduction into clinical practice of microsurgical techniques. However, the problem of restoring the peripheral nerve after its traumatic injury has not been resolved yet. A review article addresses the current state of developing stem cell technologies for peripheral nerve repair. Basic concepts of peripheral nerve regeneration after traumatic injury, methods of their restoration in experimental and clinic conditions are considered. The prospect of using stem cells of different origins is shown in the experiment by many authors, and the positive effect of stem cells on peripheral nerve regeneration is explained by their ability to secrete many trophic factors and differentiation to a neural phenotype. An essential issue in the tissue engineering approach is the choice of the optimal material to be used as a scaffold for large size peripheral nerve defects grafting. The article focuses on the main types of stem cells, as well as their combinations with biopolymers, which have shown efficiency in the experiment. Despite the advances in the use of the latest technologies, the search for the necessary components is underway to provide the most favorable conditions for peripheral nerve regeneration in the clinic.

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Stem Cell Technology in Peripheral Nerve Restoration

Petriv

Tsymbalyuk

Potapov

et al. 2020

EUMJ

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Neurotization of the facial nerve as an effective way to treat paralysis of mimic muscles

Skaliitchouk

Gaivoronsky²,

Vinogradov³

et al. 2023

Kazan Med J

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Pathologies of the facial nerve are one of the most common types of pathology of the peripheral nervous system. In the structure of lesions of the cranial nerves, this pathology occupies the first place. The clinical picture of facial nerve damage of various genesis is rather monotonous and manifests itself as persistent paresis or paralysis of the facial muscles. The literature describes a large number of different highly effective techniques aimed at restoring the function of the facial nerve and mimic muscles, examples of which are numerous conservative and surgical methods for the treatment of facial nerve neuropathy. The review presents the most common method of mimic muscles paralysis surgical treatment facial nerve neurotization. The essence of this surgical intervention is in suturing to the affected facial nerve the trunk or a portion of individual fibers of the intact nerve-neurotic, which can be the hypoglossal, masticatory, phrenic, accessory, glossopharyngeal nerves, as well as the descending branch of the hypoglossal nerve and the anterior branches of the C2C3 cervical nerves. Currently, options for the combined use of various donor nerves and autoextensions are gaining popularity among neurosurgeons, due to more favorable results in restoring the function of the facial nerve, as well as with an individual approach to each patient. The main stages of neurotization of the facial nerve include the isolation and intersection of the facial nerve, the isolation and intersection of the trunk or individual fibers of the neurotizer, the execution of the suture of the nerve in the end to end or end to side method. Particular attention should be paid to the most innovative method of facial nerve neurotization facial nerve cross-plasty, during which an anastomosis between the damaged and intact facial nerves using autotransplants from the gastrocnemius nerve or a free muscle graft, including the tender muscle and the anterior branch of the obturator nerve is performed. The process of restoring facial nerve function and regressing characteristic symptoms takes a long period of time and requires specialized restorative treatment.

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Диференційовані Методи Хірургічного Лікування Хворих З Наслідками Ушкоджень Лицевого Нерва

Cited by 2 publications

References 7 publications

Stem Cell Technology in Peripheral Nerve Restoration

Stem Cell Technology in Peripheral Nerve Restoration

Neurotization of the facial nerve as an effective way to treat paralysis of mimic muscles

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