Диагностическая значимость выявления нейтрализующих антител к SARS-CoV-2

The aim: To establish the clinical and immunological features of the course of caries in young people who have suffered from the coronavirus disease. Materials and methods: The main group consisted of 30 people aged 20,6±2,4 years who suffered from the Covid19 coronavirus infection 6,1±1,2 months ago. All patients underwent a dental and immunological examination. Results: The analysis of the indicators of the dental status revealed the possibility of the existence of a relationship between the signs of the transferred acute viral infection SARS-Cov2 and the development of dental caries, first, under the condition of reduced caries resistance. In the immune system of the examined patients were found significant changes, which definitely played a pathogenetic role in the development and progression of the carious process. They were manifested by changes of varying degrees of severity, which were both unidirectional and opposite in nature: T-lymphocyte deficiency, in particular, mainly due to T-cytotoxic lymphocytes/suppressors, an increased level of B-lymphocytes and an increased level of activated CD54+ cells of T-lymphocytes. Conclusions: In young people with dental caries who have suffered a coronavirus infection during the last 6 months, the prevalence of caries and its intensity are significantly higher than in the comparison group. Violations in the cellular and humoral links of the immune system, which combined with the pro-in¬flammatory profile of the blood serum, the phenomenon of immunotoxicosis, contributed to the further progression of the carious process in the oral cavity.

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Indicators of Dental Health and Local Immunity in Young Adults Who Have Suffered From Coronavirus Infection

Kolenko

Timokhina

Lynovytska

et al. 2023

Wiad Lek

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The aim: To determine the dental status and state of local immunity in young adults who have suffered from the coronavirus disease. Materials and methods: The main group consisted of 30 people aged 20-22 years, who suffered from the coronavirus infection Covid19 6.1±1.2 months ago. The comparison group included 20 people who did not have a coronavirus infection. The control group consisted of 35 people, randomized by age and sex, who did not have signs of caries and periodontal tissue disease and did not have coronavirus disease. All patients were examined for dental status and local immunity. Results: The analysis of indicators of dental status revealed the possibility of the existence of a relationship between the signs of acute SARS-Cov2 viral infection and the development of caries and periodontal tissue diseases. Significant changes in the local immunity of the oral cavity were found in the examined patients, which had a pathogenetic influence on the development and progression of caries and periodontal tissue diseases: a significant increase in the level of Ig G, as well as a probable decrease in the concentration of SIg A relative to the comparison group, a probably higher normative value of pathogenic small- and medium-molecular CICs with a significant decrease in the level of physiological large-sized CICs relative to the comparison group, a decrease in the content of anti-inflammatory IL-4, as well as increased concentration of pro-inflammatory cytokines. Conclusions: Young adults who have suffered a coronavirus infection during the last 6 months have significantly higher caries prevalence, bleeding index, PMA index and hygiene index, halitosis, which indicates deeper tissue damage and tooth pathology with the formation of dentition defects than in the comparison group. Indicators of local immunity of the oral fluid have a deep and specific character.

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Диагностическая значимость выявления нейтрализующих антител к SARS-CoV-2

Cited by 3 publications

References 21 publications

The Profile of Specific Antibodies to Sars-Cov-2 in Residents of the Central and Eastern Regions of Ukraine

The Profile of Specific Antibodies to Sars-Cov-2 in Residents of the Central and Eastern Regions of Ukraine

Clinical and Immunological Features of the Course of Caries in Young People Who Have Suffered a Coronavirus Infection

Indicators of Dental Health and Local Immunity in Young Adults Who Have Suffered From Coronavirus Infection

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