Грипп У Детей: Клиника, Гематологические Показатели Интоксикации, Детоксикационная Терапия

Михайлова, Е. В.; Chudakova, Tatiana

doi:10.30906/0869-2092-2015-78-5-33-36

Cited by 4 publications

(3 citation statements)

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“…до 12 лет с тяжёлым течением гриппа отмечено снижение уровня СРБ и гематологических показателей интоксикации. Это свидетельствует о выраженном детоксикационном действии препарата, что позволяет быстро купировать клинические симптомы заболевания и сокращает продолжительность стационарного лечения [44].…”

Section: перспектива использования сукцинатов при Covid-19unclassified

The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19

Orlo

Afanasyev

Khilenko

2021

A&Ch

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The aim of the work was the search for materials from experimental and clinical studies reflecting the pathogenetic role of the possible use of succinates for the correction of hypoxia in COVID-19. Materials and methods. 79 foreign and domestic literature sources were analyzed concerning the pathogenesis of COVID-19 and the pathogenetic role of succinates in hypoxia under conditions of COVID-19, oxidative stress, and diaphragmatic dysfunction were analyzed. The literature search was carried out using Pubmed and ELIBRARY.ru databases. Results. As the analysis of the literature has shown, tissue hypoxia is the basis of COVID-19 pathogenesis, triggering the entire cascade of pathomorphological events leading to the development of multiple organ failure. A number of experimental and clinical studies (on a fairly large number of patients) reflect the positive effect of tissue hypoxia correction using succinates, both in adult patients and in children with a different spectrum of pathology associated with acute respiratory failure syndrome. Conclusion. Analysis of literature data allows to substantiate the prospect of using preparations containing succinate (reamberin, cytoflavin) in the complex therapy of severe cases of COVID-19.

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Section: перспектива использования сукцинатов при Covid-19unclassified

The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19

Orlo

Afanasyev

Khilenko

2021

A&Ch

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Section: Introductionunclassified

“…Реамберин® уменьшает выраженность системного воспалительного ответа (снижается лейкоцитоз, скорость оседания эритроцитов и уровень провоспалительных цитокинов) путем активации дезинтоксикационных систем организма [39]. Инфузия препарата Реамберин® повышает буферную емкость крови, что, безусловно, важно в условиях гипоксического ацидоза при COVID-19 [39]. Реамбе-рин® оказывает антиишемический эффект при коронарной и церебральной патологиях, что дает основания ожидать аналогичного положительного эффекта при назначении для лечения COVID-19 [40,41].…”

Section: Introductionunclassified

Pathogenetic approaches to the correction of vascular homeostasis in patients with COVID-19: A review

Shuldyakov,

Smagina,

Ramazanova

et al. 2023

Terapevticheskii arkhiv

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The adverse outcomes in patients with COVID-19 in the initial phase of the disease are often due to the development of cytokine storm, endothelial dysfunction, shifts in the hemostasis system, microangiopathy, angiocentric inflammation, and pathological angiogenesis, which require targeted therapy. Unfortunately, to date, there is still no drug with proven high efficacy. This review is to analyse the literature data on the pathogenesis of vascular homeostasis lesions and possible ways to correct the existing shifts in patients with COVID-19. When the oxygen content in the tissue decreases, one of the most important mechanisms of adaptation is the activation of the succinate oxidase pathway, but under conditions of prolonged hypoxia and intoxication, the succinate reserve is rapidly depleted. That is why exogenous of succinic acid can enhance the adaptive capabilities of the organism and improve the prognosis in patients with COVID-19. Succinic acid preparations contribute to normalization of energy exchange and reduction of oxidative stress, especially in combination with inosine, nicotinamide and riboflavin and are widely used in clinical practice in various nosological forms. Taking into account the analysis of data on the mechanisms of clinical effects of succinate-containing preparations, this group of drugs can be considered as promising with regard to the correction of vascular disorders in COVID-19.

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Effects of succinates on the inflammatory response: a review

Lazarev,

Anchutin

2023

Annals of Critical Care

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INTRODUCTION: Endogenous succinate functions as a pro-inflammatory factor, while exogenous succinate — as an anti-inflammatory factor. The mechanisms of effect of succinates on the inflammatory response are not fully understood. OBJECTIVE: Generalization of the current scientific knowledge on the use of exogenous succinate in inhibition of the inflammatory response. MATERIALS AND METHODS: The PubMed, Web of Science, Google Scholar, Scopus, and eLibrary international databases were used to search for relevant articles. The search keywords were: “succinic acid”, “amber acid”, “inflammation”, “meglumine sodium/solution”. The search was limited to articles published between 2012 and December 2022. The inclusion criteria were: 1) research focused on the cellular energy supply in inflammation; 2) effects of succinate on the inflammatory response intensity due to changes in the cellular energy supply; 3) correlation of the cellular energy supply with clinical and laboratory inflammatory indicators when succinate-containing drugs are used; 4) original studies. RESULTS: The initial identification analysis included over 200 published studies. After the screening, 84 full-text articles meeting the selection criteria were included in the final review: 31 literature reviews, 24 of which are dedicated to the pro-inflammatory effects of endogenous succinate, and 7 — to the anti-inflammatory effect of exogenous succinate in succinate-containing agents; and 53 original scientific articles: 27 articles are dedicated to the research of molecular mechanisms of endogenous succinate, and 26 articles are dedicated to the study of the clinical use of succinate-containing drugs. CONCLUSIONS: Endogenous succinate is defined as the most important pro-inflammatory factor. Exogenous succinate has a pronounced anti-inflammatory effect mediated by normalization of the immune cell energy supply in hypoxia. No studies have been found on the differences in the mechanism of action of endogenous and exogenous succinate.

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Грипп У Детей: Клиника, Гематологические Показатели Интоксикации, Детоксикационная Терапия

Cited by 4 publications

References 0 publications

The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19

The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19

Pathogenetic approaches to the correction of vascular homeostasis in patients with COVID-19: A review

Effects of succinates on the inflammatory response: a review

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