Возрастные И Гендерные Особенности Циркулирующих Иммунных Комплексов И Липидного Метаболизма При Воспалительных Заболеваниях Кишечника

Abstract

of life that makes IBD one of important medical and social problems and involves search for new directions in stu dying the etiology and pathogenesis in order to improve me thods for the prevention and treatment of this pathology [1,2]. The continued interest of scientists in this pathology is associated with an increase in IBD morbidity all over the world. According to some scientists, this situation is due to UDC 616.344.002+577.115/316.346 Abstract. Background. The purpose of the present work was to assess the level of circulating immune comple- xes (CIC) and lipid metabolism state in patients with inflammatory bowel disease (IBD). Materials and methods.We examined 80 patients with IBD: 53 with ulcerative colitis (UC) and 27 with Crohn's disease (CD). Depending on the gender, they were divided into two groups: 40 womеn and 40 men. Also, depending on the age, all patients were divided into three groups: young (45 individuals - 28 with UC and 17 with CD); middle-aged (15 persons -10 with UC and 5 with CD); elderly (20 patients - 15 with UC and 5 with CD). The control group included 20 apparently healthy individuals. In patients' blood serum, the levels of CIC, total cholesterol, triglycerides, phospholipids, high-density, low-density and very low-density lipoprotein cholesterol were determined, as well as atherogenic index. Results. Serum level of CIC significantly exceeded the normal values in women with IBD - by 1.57 times (p < 0.05), which can be considered as an indicator of inflammation intensity, involvement of the immune system in the pathological process. In women with UC, the content of CIC was significantly increased - by 1.62 times (p < 0.05) compared to the control group. In IBD, the level of CIC depended on the age of patients; it was significantly increased - by 1.5 times (p < 0.05) and 1.4 times (p < 0.05) - in middle-aged patients and in the elderly, respectively, compared to a group of young patients. The correlation between the level of CIC and the age (r = +0.552; p = 0.025) was established. The violation of lipid metabolism was observed in women with UC, which manifested in 1.7-time reduction of serum triglycerides (p < 0.001); in men with CD, a decrease in this indicator by 1.5 times (p < 0.05) occurred compared to the control group. In women with UC, the serum level of very low-density lipoproteins was 2 times lower (p < 0.05), and in men with ) as compared to controls. A probable reduction in the content of triglycerides was detected: by 1.5 times (p < 0.05) and 1.6 times (p < 0.05) in young patients with UC and CD, respectively, and by 1.6 times (p < 0.05) in middle-aged patients with CD. In parallel, there was a pronounced tendency to cholesterol lowering in all young patients with IBD. A probable decrease in the atherogenic index was detected in young patients. Conclusions. The completed studies allowed establishing and confirming the presence of biochemical changes in patients with IBD (lipid metabolism and the content of CIC), which play the main role in the pathogenetic mechanisms...