Актуальні європейські рекомендації щодо ведення хронічного гiпопаратиреозу в дорослих. За матеріалами 17-го конгресу Європейського товариства ендокринологів, Дублін, Ірландія, 16–20 травня 2015 р.

Komissarenko, Yu. I.; Bobryk, M.I.; Сидорова, Ю. В.; Бурка, О. А.

doi:10.22141/2224-0721.5.69.2015.75092

Cited by 2 publications

(5 citation statements)

References 2 publications

(2 reference statements)

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“…In our study, hypocalcemia was significantly more common in younger patients. Previous studies have published conflicting results with respect to age as a risk factor for the development of PostHypo (6,14,42,(44)(45)(46). Malignant pathology was not related to PostHypo in our study, although other studies have confirmed this correlation (15,47,48).…”

Section: Discussioncontrasting

confidence: 80%

“…It results from an accidental gland injury, removal of the parathyroid glands, or their devascularization (4). PostHypo may be transient when it recovers within a few weeks or one month after thyroid surgery (5), or chronic when hypoparathyroidism persists for at least six months postoperatively (6,7). The incidence of temporary and permanent post-surgical hypoparathyroidism is estimated between 19-38% and 0-3%, respectively (8,9).…”

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confidence: 99%

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Identification of Patients at High Risk for Postsurgical Hypoparathyroidism

Kakava

Tournis

Makris

et al. 2020

In Vivo

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Background/Aim: Postsurgical hypoparathyroidism (PostHypo) is a common complication after total thyroidectomy. We studied the risk factors associated with PostHypo. Patients and Methods: The study included 109 women, (mean age: 50.7±10.75 years), who underwent total thyroidectomy for thyroid diseases. Results: Based on the development of biochemical hypocalcemia on the first postoperative day following total thyroidectomy, (cCa<8.4 mg/dl), 37 women developed PostHypo and 72 did not. Younger age, a lower preoperative corrected calcium and the presence of parathyroid glands in the specimens were related to the development of PostHypo. Of all patients, 51.4% had a vitamin D deficiency. A parathyroid hormone (PTH) value ≤9.4 pg/ml was 84.9% sensitive and 71.4% specific to predict PostHypo on the 1 st postoperative day. A 50% reduction of the PTH value on the 1 st postoperative day from the preoperative level could identify patients who develop PostHypo with 76% sensitivity and 75% specificity. Conclusion: PTH postoperative measurement and its alteration from the preoperative level can be used to identify patients who are at increased risk to develop PostHypo.

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Section: Discussioncontrasting

confidence: 80%

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confidence: 99%

Identification of Patients at High Risk for Postsurgical Hypoparathyroidism

Kakava

Tournis

Makris

et al. 2020

In Vivo

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“…It was recommended at the European Congress of Endocrinology (May 2015) to determine the levels of albumin, magnesium, and vitamin D3 in serum [ 46 , 47 ]. Hypomagnesemia may cause a decrease in PTH secretion, while vitamin D deficiency is a risk factor for the development of PSHP [ 27 – 29 , 48 ].…”

Section: Diagnosis and Prognosis Of Post-surgical Hypoparathyroidismmentioning

confidence: 99%

“…Treatment of PSHP mainly aims at reducing hypocalcemia symptoms (target values of ionized calcium — 1.10–1.25 mmol/L, albumin-adjusted total calcium — 2.1–2.3 mmol/L), maintaining serum phosphate levels at the upper limit of the reference range, preventing hypercalciuria and the resulting development of nephrolithiasis, nephrocalcinosis and chronic renal failure [ 46 , 47 , 58 – 60 ].…”

Section: Principles Of Drug Therapymentioning

confidence: 99%

“…However, it is not always possible to restore the calcium and phosphorus balance in the body completely, there is a risk of developing osteosarcomas [ 69 , 70 , 72 ]. The European working group on the management of patients with chronic hypoparathyroidism recommends against the routine use of recombinant PTH, unless their use is indicated individually in severe cases refractory to traditional therapy [ 46 , 47 ].…”

Section: Principles Of Drug Therapymentioning

confidence: 99%

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Postoperative Hypoparathyroidism: Prognosis, Prevention, and Treatment (Review)

Melikyan¹,

Меньков²

2020

Sovrem Tehnol Med

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This review summarizes the results of studies concerning the problem of post-surgical hypoparathyroidism, a common complication of thyroid gland surgery, decreasing the quality of life in patients and, in some cases, leading to disability. A search for publications was carried out in electronic databases Web of Science, Scopus, Academic Search Complete (EBSCO), eLIBRARY, using keywords. The search depth was 7-10 years. Prevalence of post-surgical hypoparathyroidism was evaluated, the pathogenetic causes of the disease development, its clinical forms, methods of diagnosis and treatment were studied. It has been found that there is no single algorithm for analyzing the prognostic factors for the development of this pathological condition. It is emphasized that drug therapy of post-surgical hypoparathyroidism has a number of adverse effects. Therefore, the issues of prevention and surgical correction are of particular relevance. However, controversial opinions of contemporary authors about their clinical effectiveness determine the scientific and practical significance of further research on these issues.

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Cited by 2 publications

References 2 publications

Identification of Patients at High Risk for Postsurgical Hypoparathyroidism

Identification of Patients at High Risk for Postsurgical Hypoparathyroidism

Postoperative Hypoparathyroidism: Prognosis, Prevention, and Treatment (Review)

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