Φ-order spectrophotokinetic characterisation and quantification of trans-cis oxyresveratrol reactivity, photodegradation and actinometry

Maafi, Mounir; Al-Qarni, Mohammed Ahmed

doi:10.1016/j.saa.2017.06.067

Cited by 14 publications

(15 citation statements)

References 32 publications

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“…2,4-Dihydroxyiodobenzene was allowed to react with acrylic acid under Heck reaction conditions (Pd catalyzed reaction) to provide an intermediate that, after decarboxylation and coupling with 3,5-dihydroxyiodobenzene through Heck reaction, yielded ORV (Figure 5) It is noteworthy that ORV is light-sensitive, as it was reported that this compound rapidly underwent a trans-cis-photoisomerization and photodegradation by UV irradiation in ethanol solution [137]. It is noteworthy that ORV is light-sensitive, as it was reported that this compound rapidly underwent a trans-cis-photoisomerization and photodegradation by UV irradiation in ethanol solution [137].…”

Section: Chemical Synthesismentioning

confidence: 99%

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Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Likhitwitayawuid

2021

Molecules

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Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The current review provides a more comprehensive summary, covering research from 1955 to the present year. Oxyresveratrol occurs in both gymnosperms and angiosperms. However, it has never been reported in plants in the subclass Sympetalae, and this point might be of both chemotaxonomic and biosynthetic importance. Oxyresveratrol can be easily obtained from plant materials by conventional methods, and several systems for both qualitative and quantitative analysis of oxyresveratrol contents in plant materials and plant products are available. Oxyresveratrol possesses diverse biological and pharmacological activities such as the inhibition of tyrosinase and melanogenesis, antioxidant and anti-inflammatory activities, and protective effects against neurological disorders and digestive ailments. However, the unfavorable pharmacokinetic properties of oxyresveratrol, including low water solubility and poor oral availability and stability, have posed challenges to its development as a useful therapeutic agent. Recently, several delivery systems have emerged, with promising outcomes that may improve chances for the clinical study of oxyresveratrol.

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Section: Chemical Synthesismentioning

confidence: 99%

“…It is noteworthy that ORV is light-sensitive, as it was reported that this compound rapidly underwent a trans - cis -photoisomerization and photodegradation by UV irradiation in ethanol solution [ 137 ].…”

Section: Productionmentioning

confidence: 99%

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Likhitwitayawuid

2021

Molecules

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“…NIF, is hence, much more photodegradable than DBZ under irradiation by the same mixed-wavelength Lamp #4. A finding that corroborates the relative photoreactivity of these drugs under monochromatic light, according to the ranking scale that was established based on each drug's range of its -factor over its absorption region [15][16][17][18][19][20]. This scale was thought to set the foundation for a database on photoactive drugs.…”

Section: Kinetics Of the Drugs Under Polychromatic Lightmentioning

confidence: 81%

“…Our work on monochromatic light irradiation, was also extended to photoreversible drugs such as Montelukast, Sunitinib and oxyresveratrol [16][17][18][19], and multi-consecutive photodegradation reactions such that of Riboflavin [20]. For these cases, semi-empirical methods allowed to derive algebraic formulae for the integrated rate-law equations according to -order kinetics.…”

Section: Introductionmentioning

confidence: 99%

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Polychromatic-Light Irradiation Kinetics of Dacarbazine and Nifedipine. Application as New Reliable UVA-drug-actinometers.

Maafi

Al-Qarni

2021

Preprint

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The photokinetic behaviour of materials driven by polychromatic light is an area that has not received a lot of attention in the literature. Most often, such photokinetic data is treated by thermal kinetic models (i.e., the classical 0th -, 1st - or 2nd -order equations). Such models were not analytically derived from the rate-laws of the photodegradation reactions. Polychromatic light kinetic modelling is hence of importance, as a means to providing adequate toolkits and metrics. This paper aims at proposing two reliable drug-actinometers useful for polychromatic UVA range. The general actinometric methodology offered here is also useful for any drugs/materials obeying a primary photoprocess where both reactant and photoproduct absorb the incident light, of the \(AB{\left(1{\Phi }\right)}_{{\epsilon }_{B}\ne 0}\) type. The present method has been consolidated by the η-order kinetics, a mathematical model analytically derived from the photosystem’s rate-law. This represents the first ever equation in the literature, to model polychromatic light of this reactive system. This framework further demonstrated the lamp-specificity of actinometers. Overall, Dacarbazine and Nifedipine photodegradations obeyed η-order kinetics, and stand as effective actinometers that can be recommended for the ICH Q1b photostability testing.

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Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer study

Matencio

Dhakar

Bessone

et al. 2020

Carbohydrate Polymers

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Φ-order spectrophotokinetic characterisation and quantification of trans-cis oxyresveratrol reactivity, photodegradation and actinometry

Cited by 14 publications

References 32 publications

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems

Polychromatic-Light Irradiation Kinetics of Dacarbazine and Nifedipine. Application as New Reliable UVA-drug-actinometers.

Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer study

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