Study of oxyresveratrol complexes with insoluble cyclodextrin based nanosponges: Developing a novel way to obtain their complexation constants and application in an anticancer study

Oxyresveratrol induces apoptosis and inhibits cell viability via inhibition of the STAT3 signaling pathway in Saos‑2 cells

“…ORES inhibits the viability of Saos-2 cells. although oreS has been shown to inhibit prostate and colon cancer cell viability (30), it remains unknown whether oreS can inhibit osteosarcoma cell viability. as a natural phenolic compound, oreS is a resveratrol analogue that contains an additional hydroxyl group in the aromatic ring (22).…”

“…as a natural ingredient, which is primarily found in Morus alba l., oxyresveratrol (oreS) has extensive biological effects. over the previous two decades, oreS has been reported as a powerful tyrosinase activity inhibitor (22,23), and also as having antioxidative (24,25), anti-inflammatory (26,27), anticancer (28)(29)(30) and anti-lipogenesis properties (31). oreS has also been observed to exert strong neuroprotective effects, as it reduces neuronal oxidative damage (32,33).…”

“…oreS has also been observed to exert strong neuroprotective effects, as it reduces neuronal oxidative damage (32,33). notably, oreS and its derivatives have been reported to serve an efficient role against various types of cancer, such as head and neck carcinoma (28), neuroblastoma (29), prostate (30), kidney (34) and lung cancer (35). However, it remains unknown whether ORES has an effect on the inhibition of osteosarcoma cells and the mechanism by which oreS inhibits tumor cell viability.…”

Nanosponges for the protection and release of the natural phenolic antioxidants quercetin, curcumin and phenethyl caffeate

“…By a sensible choice of the synthetic strategy, it is possible to obtain materials with tunable properties and, in particular, to achieve sensitivity to external stimuli such as pH variations. 19,[21][22][23][24][25] CD-based NSs have been proposed to improve the bioavailability of polyphenols, such as resveratrol, 26,27 oxyresveratrol, 27,28 curcumin, 29 quercetin, 30 ferulic acid, 31 rutin, 32 phlorizin 32 and chlorogenic acid. 32 However, despite the growing interest toward NSs as carriers of polyphenols, the antioxidant activity of these materials has been seldom investigated.…”

“…32 However, despite the growing interest toward NSs as carriers of polyphenols, the antioxidant activity of these materials has been seldom investigated. [27][28][29] To the best of our knowledge, the efficiency of the reaction of polyphenols loaded into nanosponges with alkylperoxyl radicals (ROO ), which are the chain carrying ones of peroxidation in bio-organic systems, 9,33 has never been studied in detail. Most popular assays that are used to measure the antioxidant activity of new materials rely on the decay of coloured stable radicals such as 2,2-diphenyl-1-picrylhydrazyl radical (DPPH ) in alcohol solvents.…”