μ-Opioid Agonists Stimulate Growth Hormone Secretion in Immature Rats

Eason, Margaret G.; Francis, R. S.; Kuhn, Cynthia M.

doi:10.1159/000127077

Cited by 8 publications

(4 citation statements)

References 28 publications

(38 reference statements)

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“…But, in females, estrogen had an opposite effect as that for testosterone in males and when naloxone administered to immature female rats advanced the age of onset of puberty (17). This idea was repeated in ovariectomized rats when LH responses to opioids were antagonized by naloxone (18,19). In contrast to their effects on LH, most opioids and their analogs appear not to affect FSH (20).…”

Section: Discussionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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Abstract:Background: Knowledge about harmful effects of morphine on hormone secretion seems to be necessary. The aim of the present study was to evaluate the effect of pentoxifylline on side effects derived by morphine on hypophyso-gonadal hormones of male rats. Methods: 32 male rats were divided into the 4 groups of OSS: control (received 40 g Sucrose/l drinking water and intraperitoneal injection of 1 l/kg normal saline), OMS: morphine group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and intraperitoneal injection of 1 l/kg normal saline), NMS: morphine+naltrexane group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and IP injection dose of 10 mg/kg/ml/day Naltrexane) and PMS: morphine + pentoxifylline group (received 0.4 mg/dl + 40 g Sucrose/l in drinking water and IP injection dose of 12 mg/kg/ml/day Pentoxifylline) for 56 days, respectively. Results: Serum levels of testosterone, LH, FSH hormones were measured. Pentoxifylline increased serum levels of testosterone, LH, FSH hormones compared to control, morphine and morphine-naltrexane groups. Conclusion: Pentoxifylline has a signifi cant effi cacy for increasing serum levels of sexual hormones. Considering that Pentoxifylline is safe and cheap, with easy application, we suggest for the usage of this drug for improving semen parameter's quality before performing ART for the treatment of morphine addicts (Fig. 1, Ref. 31). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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“…On the other hand, chronic administration has led to no (61,80) or to stimulatory effect (81). Studies on the pathways and mechanisms involved on the effects of opioids on GH release show that various types of opioid receptors (μ, κ, δ) are implicated, but their activation effects vary between reports (82,83,84). A reset of the hypothalamic GH pulse generator via opioid receptor stimulation is also a possible mechanism (85).…”

Section: Somatotroph Axismentioning

confidence: 99%

MECHANISMS OF ENDOCRINOLOGY: Endocrinology of opioids

Fountas

Chai

Kourkouti

et al. 2018

European Journal of Endocrinology

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The use of opioids has grown substantially over the past two decades reaching the dimensions of a global epidemic. These drugs have effects on multiple levels of the endocrine system through mechanisms which are still not fully elucidated, and awareness of their endocrine sequelae is vital for all specialists prescribing or managing patients on them. Hypogonadism is the most well recognised consequence of opioid use (prevalence 21-86%) which, however, may remain undiagnosed with potential adverse outcomes for the patients. Although less frequent, cortisol deficiency can be also found. Furthermore, there is negative impact on bone health (with reduced bone mineral density and increased fracture risk) and occasionally hyperprolactinaemia, whereas the clinical significance of alterations in other hormones remains to be clarified. Discontinuation or reduction of the opioid and, in cases of chronic pain, consideration of alternative therapies for pain relief are potential management options. Hormonal replacement, especially when the above measures are not practically feasible, needs to be considered. Further studies are needed to clearly establish the prevalence of hormonal abnormalities with various regimes, doses and routes of opioids and to address reliably the long-term benefits and risks of hormonal treatment in patients on opioids. Until evidence-based, safe and cost-effective clinical guidelines become available, periodical assessment of the gonadal and adrenal function (particularly when relevant clinical manifestations are present) and evaluation of the bone health status are advised.

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“…(1990) showed that naloxone also decreased GH concentration in heifers. In neonatal rats, stimulation of μ‐ and κ‐opioid receptors resulted in an increase or inhibition of GH release, respectively (Eason et al. 1996).…”

Section: Introductionmentioning

confidence: 99%

Regulation of Growth Hormone Secretion in Nursing Ewes: An Involvement of μ‐Receptor Subtype

Górski

Misztal

Dobek

et al. 2011

Reprod Domestic Animals

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Suckling by newborns induces a surge of lactogenic hormones, that is prolactin and growth hormone (GH), in mother's body, with endogenous opioid peptide (EOP) participating in generation of this surge. The aim of the current study was to investigate which types of opioid receptors are involved in generation of the GH surge in ewes during suckling. A series of intracerebroventricular infusions of opioid receptors antagonists: naloxone (for all types of receptors), naloxonazine (specific for μ receptor) and 5'-guanidinonaltrindole (GNTI--specific for κ receptor) and the vehicle (control) were performed in nursing sheep during the fifth week of lactation. All infusions were carried out in a serial manner: five 30-min infusions (60 μg/60 μl) from 10:00 to 15:00, at 30-min intervals. The period of the experiment consisted of the non-suckling (10:00-12:30) and suckling (12:30-15:00) periods. Simultaneously, blood samples were collected at 10-min intervals to determine plasma GH concentration by radioimmunoassay. Suckling evoked a rapid increase in GH concentration in control ewes. Naloxone and naloxonazine significantly decreased both the basal GH release in the non-suckling period and the suckling-induced GH surge. Specifically, the suppressive effect concerned either the duration or the amplitude of the GH surge. In contrast, GNTI did not significantly affect the GH release. In conclusion, the EOPs may affect the regulatory process of GH secretion in lactating sheep, especially through μ opioid receptor.

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μ-Opioid Agonists Stimulate Growth Hormone Secretion in Immature Rats

Cited by 8 publications

References 28 publications

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

MECHANISMS OF ENDOCRINOLOGY: Endocrinology of opioids

Regulation of Growth Hormone Secretion in Nursing Ewes: An Involvement of μ‐Receptor Subtype

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