μ‐Opioid agonists for preventing emergence agitation under sevoflurane anesthesia in children: a meta‐analysis of randomized controlled trials

Tan, Yuan; Shi, Yunfei; Ding, Hui; Kong, Xiangbin; Zhou, Haijiao; Tian, Jinhui

doi:10.1111/pan.12815

Cited by 29 publications

(21 citation statements)

References 51 publications

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“…It is encountered in up to 80% of children receiving inhalational anesthetics . It has been suggested that the altered cognitive perception typical of EA might be related to rapid recovery from sevoflurane and desflurane anesthesia . Agitation during recovery is associated with many risks, including self‐inflicted injury to the pediatric patient or the surgical site .…”

Section: Introductionmentioning

confidence: 99%

“…1 It has been suggested that the altered cognitive perception typical of EA might be related to rapid recovery from sevoflurane and desflurane anesthesia. 2 Agitation during recovery is associated with many risks, including self-inflicted injury to the pediatric patient or the surgical site. 3 Agitation events prolong recovery, extend discharge time, and contribute to unexpected readmission and increased costs, which are major problems that continue to be undertreated in pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of dexmedetomidine for perioperative morbidities in pediatric tonsillectomy: A metaanalysis

Cho¹,

Yoon

Jin

et al. 2017

The Laryngoscope

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show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of dexmedetomidine for perioperative morbidities in pediatric tonsillectomy: A metaanalysis

Cho¹,

Yoon

Jin

et al. 2017

The Laryngoscope

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“…12 µ-opioid agonists were found effective in decreasing the incidence of EA under sevoflurane anesthesia but postoperativenausea and vomiting were increased. 13 In a study by Fang et al, the efficacy of midazolam, dexmedetomidine, ketamine, fentanyl, and propofol were compared for the prevention of sevoflurane-related EA in children with placebo. They found that all of these agents have decreased the incidence of EA but dexmedetomidine was considered the most effective agent in their study.…”

Section: Letter To the Editormentioning

confidence: 99%

Pediatric Emergence Agitation

Honca¹

2016

Res Pract Anesthesiol Open J

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“…Furthermore, intranasal DEX (1 µg/kg) and midazolam (0.2 mg/kg) were demonstrated to be equally effective in decreasing anxiety at parental separation; however, midazolam was superior in terms of providing satisfactory conditions during mask induction (29). A study by Tan et al (30) revealed that intraoperative continuous infusion of low-dose DEX (0.2 µg/kg/h) was able to reduce EA following desflurane anesthesia without hemodynamic compromise or delayed awakening in pediatric patients undergoing strabismus surgery.…”

Section: Group ------------------------------------------------------mentioning

confidence: 99%

Effect of dexmedetomidine combined with sufentanil on preventing emergence agitation in children receiving sevoflurane anesthesia for cleft palate repair surgery

Luo

Cao

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to observe whether dexmedetomidine (DEX) combined with sufentanil decreased emergence agitation (EA) in children receiving sevoflurane anesthesia for cleft palate repair surgery. Children undergoing elective cleft palate repair surgery were randomly allocated into the DEX + sufentanil group (group DS; n=50) and the normal saline + fentanyl group (group SF; n=50). Patients in group DS were treated with 0.5 µg/kg DEX prior to induction of anesthesia, whereas patients in group SF received an equal volume of normal saline. Sufentanil (0.2 µg/kg) was administered to induce anesthesia, and 30 min before the end of surgery for patients in group DS. Fentanyl (2 µg/kg) was administered at the same time point for patients in group SF. Mean arterial pressure (MAP), heart rate (HR), duration of surgery and anesthesia, and the dosage of remifentanil were assessed. EA score, Pediatric Anesthesia Emergence Delirium (PAED) score and the Children and Infants Postoperative Pain Scale (CHIPPS) score were documented every 15 min in the post-anesthesia care unit (PACU). The number of cases requiring fentanyl (1 µg/kg) and the recovery profile data were analyzed. Compared with group DS (P<0.05) and the baseline (P<0.05), HR and MAP were significantly increased in group SF immediately following tracheal intubation and extubation. Mean values of maximum EA, PAED and CHIPPS scores were significantly reduced in group DS compared with group SF at 0 (P<0.01), 15 (P<0.05), and 30 min (P<0.05) after arrival at PACU. The incidence of EA in group SF was significantly increased compared with group DS (P<0.05). The dosage of remifentanil during the surgery and the number of cases requiring fentanyl (1 µg/kg) in group DS were significantly decreased compared with group SF (P<0.05). The findings of the present study suggested that DEX combined with sufentanil was able to effectively decrease the incidence of EA in children receiving sevoflurane anesthesia for cleft palate repair surgery.

show abstract

μ‐Opioid agonists for preventing emergence agitation under sevoflurane anesthesia in children: a meta‐analysis of randomized controlled trials

Cited by 29 publications

References 51 publications

Efficacy of dexmedetomidine for perioperative morbidities in pediatric tonsillectomy: A metaanalysis

Efficacy of dexmedetomidine for perioperative morbidities in pediatric tonsillectomy: A metaanalysis

Pediatric Emergence Agitation

Effect of dexmedetomidine combined with sufentanil on preventing emergence agitation in children receiving sevoflurane anesthesia for cleft palate repair surgery

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