κ-casein gene (CSN3) allelic polymorphism in Russian cattle breeds and its information value as a genetic marker

Sulimova, G. E.; Azari, M Ahani; Rostamzadeh, Jalal; Abadi, M R Mohammad; Lazebny, O. E.

doi:10.1134/s1022795407010115

Cited by 51 publications

(34 citation statements)

References 15 publications

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“…Genotyping of milk proteins, such as k-casein gene is extremely important for selection practice to improve industrial milk production (Patel et al, 2007;Sulimova et al, 2007). In the present study, the primers K2 and KY amplified two DNA fragments with sizes 379 bp and 280 bp, respectively.…”

Section: Discussionmentioning

confidence: 96%

Genotyping of kappa-casein gene in Egyptian buffalo bulls

Dayem¹,

Mahmoud²,

Nawito³

et al. 2009

Livestock Science

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Section: Discussionmentioning

confidence: 96%

Genotyping of kappa-casein gene in Egyptian buffalo bulls

Dayem¹,

Mahmoud²,

Nawito³

et al. 2009

Livestock Science

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“…They have been grouped into α s1 -casein, α s2 -casein, β-casein, K-casein and γ-casein derived from β-casein degradation. In cattle, the entire cluster is located on chromosome 6 (6q31) with a length of 200 to 250 kb (Sulimova et al 2007;Azevedo et al 2008;Rachagani and Gupta, 2008). Numerous genetic variants have been identified for caseins; their influence on milk composition has been demonstrated, and they have been used as an additional selection criterion in cattle breeding (Caroli et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Convenient genotyping of nine bovine K-casein variants

Contreras¹,

Jaramillo²,

Parra‐Bracamonte³

et al. 2011

Electro Journal of Biotech

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K-casein gene polymorphisms are of major importance in the dairy industry due to their association with different quality and productive traits (i.e., milk protein). Several methods for genotyping this gene have been proposed; however, none are focused on the simultaneous discrimination of nine K-casein variants. A strategy based on PCR-RFLP was designed to characterize nine K-casein variants (A, B, C, E, F 2 , G, H, I and J) and used to genotype three cattle populations: Gyrholando (3/8 Gyr x 5/8 Holstein), Charolais and Carora. The B variant was the most frequent in the Charolais and Carora breeds, with allelic frequencies of 0.60 and 0.59, respectively. In the Gyrholando breed, four variants were found, with the A variant being the most frequent and E and H the least. The genotyping strategy was effective in detection and differentiation of K-casein variants, and it is proposed for use in laboratories with minimal molecular biology equipment for genotyping and evaluation of the phenotypic effects of nine K-casein variants on milk production and quality.

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“…It has been reported that the alleles of the kappa-casein gene, excluding the A and B alleles, are found in only certain cattle breeds and at a rather low frequency 3 . The most frequently observed alleles in cattle breeds, namely, the A and B alleles, have emerged consequential to a base change in the κ-CN gene 14 .…”

Section: Kappa-casein (κ-Cn)mentioning

confidence: 99%

“…While the majority of these alleles have been determined to exist in only a few cattle breeds at a low frequency, it has been ascertained that the A and B alleles are very common and are found in almost all cattle breeds 3 . It has been reported that, of the casein proteins, κ-CN has affect on milk yield, milk protein composition and milk fat content 4 .…”

Section: Introductionmentioning

confidence: 99%

“…In cattle, it has been ascertained that the κ-CN gene has 12 alleles, named as A, B, B2, C, E, F, F1, G, H, I, A(1) and J 3 . While the majority of these alleles have been determined to exist in only a few cattle breeds at a low frequency, it has been ascertained that the A and B alleles are very common and are found in almost all cattle breeds 3 .…”

Section: Introductionmentioning

confidence: 99%

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Türkiye’deki Holştayn, İsviçre Esmeri ve Simmental Sığır Irklarında Kapa-Kazein, Büyüme Hormonu ve Prolaktin Genlerinin Allel Frekansları

Akyüz¹,

Arslan²,

Bayram³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryThe purpose of this study was to examine the kappa-casein (κ-CN), growth hormone (bGH) and prolactin hormone (PRL) gene polymorphisms in the Holstein (n=150), Simmental (n=50) and Brown Swiss (n=50) cattle breeds in Turkey. In order to determine the κ-CNHindIII, PRL-RsaI and bGH-AluI polymorphisms, polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) were performed. A 443 bp fragment of κ-CN, a 223 bp fragment of bGH and a 156 bp fragment of PRL were amplified. In this study, two types of alleles, A and B for κ-CN, V and L for bGH, and A and B for PRL, were observed. The cattle breeds in which the highest frequencies of the alleles were estimated, were the HL breed (0.82) for κ-CN-A, the BS breed (0.55) for κ-CN-B, the HL breed (0.85) for bGH-L, the S breed (0.34) for bGH-V, the HL breed (0.87) for PRL-A, and the BS breed (0.24) for PRL-B. According to the results of the chi-square test, a significant deviation from the Hardy-Weinberg equilibrium was determined only for the bGH locus in the investigated breeds. The present study is the first report that examines three loci (κ-CN, bGH and PRL) in three cattle breeds of European origin (Holstein, Simmental and Brown Swiss) raised in Turkey.

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κ-casein gene (CSN3) allelic polymorphism in Russian cattle breeds and its information value as a genetic marker

Cited by 51 publications

References 15 publications

Genotyping of kappa-casein gene in Egyptian buffalo bulls

Genotyping of kappa-casein gene in Egyptian buffalo bulls

Convenient genotyping of nine bovine K-casein variants

Türkiye’deki Holştayn, İsviçre Esmeri ve Simmental Sığır Irklarında Kapa-Kazein, Büyüme Hormonu ve Prolaktin Genlerinin Allel Frekansları

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