γδ T-Cell Lymphoma with Tropism for Various Types of Epithelium in a Cow

Kadota, Koichi; Wada, Yasuhiko; Ishikawa, Yoshiharu; Shibahara, Tomoyuki

doi:10.1053/jcpa.2001.0462

Cited by 22 publications

(46 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Likewise, their malignant counterparts (cases 6 and 9) showed considerably similar cytomorphology, though the cells in case 9 had more widespread cytoplasm. Although it is difficult to distinguish between the neoplastic cells in case 9 and in ordinary cutaneous lymphomas with regression of cutaneous lesions 4 , marked neoplastic invasion of hair follicles is a feature of γδ T cell lymphomas with cutaneous involvement 6,11 . There was neither CD3 nor CD79a expression in case 10.…”

Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

“…T cell malignancies such as precursor T lymphoblastic leukemia 7 and γδ T cell lymphoma 1 have been reported in BLV-infected cattle, and were thought to have no relation to the virus 5 . Sporadic lymphoid neoplasms are divisible into calf, thymic, and cutaneous forms, but more than one disease entity is included in each form 2,6,7,12,16,17,19 . Taking into account the large population of normal hematopoietic cells in the bone marrow, a fair number of myeloid leukemias must occur in cattle.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Murayama

Sato

Ikehata

et al. 2011

JARQ

View full text Add to dashboard Cite

Ten cases of bovine lymphohematopoietic neoplasms were investigated histologically, histochemically, and immunohistochemically, and were classified into eight histologic types on the basis of the origin and morphology of tumor cells. Case 1, a precursor B lymphoblastic leukemia, was positive for CD79a and terminal deoxynucleotidyl transferase. Case 2, a thymic B cell lymphoma, was also positive for these markers, but there were cytologic differences between the two cases. Cases 3-5 were diagnosed as pleomorphic B cell lymphomas, which were characterized by cytologic pleomorphism and expression of CD79a and CD5, and were etiologically associated with bovine leukosis virus (BLV). A case of diffuse large B cell lymphoma of the cerebrum (case 6) also showed a positive result for CD79a and CD5. However, the lymphoma was composed of a homogeneous population of large neoplastic cells, and was considered to be unrelated to BLV. The other B cell cases were categorized into immunoblastic (case 7) and lymphoplasmacytic (case 8) lymphomas, in which immunoglobulin-producing lymphoma cells were observed. In a cutaneous γδ T cell lymphoma (case 9), the neoplastic cells cytologically resembled those in case 6, but expressed CD3 and WC1. In case 10, an acute basophilic leukemia, some leukemia cells had intracytoplasmic granules that were metachromatic and tryptase positive but negative for naphthol AS-D chloroacetate esterase. Bovine lymphohematopoietic malignancies are classifiable into discrete histologic types according to immunophenotype. The classification is more scientific than the traditional one, the latter being based on the age of affected animals and/or the site of tumor formation.

show abstract

Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Murayama

Sato

Ikehata

et al. 2011

JARQ

View full text Add to dashboard Cite

show abstract

“…Adult-form lymphoma, which is associated with bovine leukemia virus (BLV) infection, is immunohistochemically dividable into three types; B-1a, B-1b and B-2 14 . γδ T cell lymphomas were found in BLV-negative cattle, and could be classified into several histologic subtypes 7,11 . Although adult-form lymphoma is generalized in tissue distribution 12,14 , γδ T cell lymphoma has a tendency to affect the skin and mucous membranes 7,10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…γδ T cell lymphomas were found in BLV-negative cattle, and could be classified into several histologic subtypes 7,11 . Although adult-form lymphoma is generalized in tissue distribution 12,14 , γδ T cell lymphoma has a tendency to affect the skin and mucous membranes 7,10,11 . In this paper, we describe two cases of lymphoma of innatelike lymphocyte origin (B-1 B cell lymphoma and γδ T cell lymphoma) that were thought to have arisen from the abdominal cavity.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Study of Lymphomas of Abdominal Cavity Origin in Two Cows with Bovine Leukemia Virus

Abe

Shoji²,

K³

et al. 2007

JARQ

View full text Add to dashboard Cite

Lymphoid neoplasms of abdominal cavity origin were found in two cows infected with bovine leukemia virus (BLV). Case 1 was a 3-year-old Japanese Black cow affected with a B-1 B cell lymphoma. Case 2 was a 14-year-old Japanese Black cow that developed a γδ T cell lymphoma. Immunohistochemically, CD79a-positive lymphoma cells were observed in case 1, whereas CD3-, WC1-or perforin-positive ones were seen in case 2. Despite the expression of CD5 in both lymphomas, the reactivity was surface or cytoplasmic in case 1 and surface membrane in case 2. Erythrophagia by tumor cells of both cases was considered to be due to the fact that their normal counterparts were more primitive forms than conventional lymphocytes.Discipline: Animal health Additional key words: B-1 B cell, CD5, γδ T cell JARQ 41 (2), 153 -156 (2007)

show abstract

“…Epithelial tropism is common amongst T-cell lymphosarcomas and has been reported in bovine sporadic forms involving the skin and alimentary tract (Kadota et al, 2001). Interestingly, in dogs, alimentary forms of T-cell lymphosarcomas may have increased numbers of eosinophils within the lamina propria (Ozaki et al, 2006).…”

mentioning

confidence: 99%

Multicentric T-cell Lymphosarcoma in a White-tailed Deer (Odocoileus virginianus)

Madson

Opriessnig

2009

Journal of Wildlife Diseases

View full text Add to dashboard Cite

ABSTRACT:An adult female white-tailed deer (Odocoileus virginianus) with a history of shaking, ataxia, and severe debilitation was submitted for examination. Macroscopic lesions included severe emaciation, severe abdominal and mesenteric lymphadenopathy, and several rumen-associated masses. Microscopically, the ruminal masses and lymph nodes were infiltrated by pleomorphic neoplastic lymphocytes. Similar lymphoblasts were associated with the leptomeninges, choroid plexus, and the intestinal mucosa; these cells were intensely positive for CD3 antigen, indicating their T-cell origin. Lymphoproliferative viruses (bovine leukemia virus and malignant catarrhal fever virus) or epizootic hemorrhagic disease virus were not detected by polymerase chain reaction. To our knowledge, this case represents the first report of the immunophenotype of a multicentric lymphosarcoma, metastasis involving the brain, and epitheliotropic lymphoblasts in a whitetailed deer.

show abstract

γδ T-Cell Lymphoma with Tropism for Various Types of Epithelium in a Cow

Cited by 22 publications

References 8 publications

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Immunohistochemical Study of Lymphomas of Abdominal Cavity Origin in Two Cows with Bovine Leukemia Virus

Multicentric T-cell Lymphosarcoma in a White-tailed Deer (Odocoileus virginianus)

Contact Info

Product

Resources

About