γ-Methyleneglutamic Acid InLilium martagon

Abstract

Key Word Index: Lilium martagon; Liiaceae; 'y-Methyleneglutamic Acid. Y-Methyleneglutamic acid is an aminoacid already isolated from Arachis hypogea [1], Tulipa gesneriana [2], Phyllitis scolopendrium [31, Amorpha fruticosa [5], Tetrapleura tetraptera [6], Lilium maxirnovici [7], Lilium aindidurn [8] and also identified in Humulus lupulus [9], Lilium regale [10], L. longiflorurn, Notolirium thompsonianum, Fritillaria meleagris, Haworthia coarctata [11], Poligala vulgaris [12] and Tamarindus indica [13]. It has now been identified in Lilium martagon which is grown in the Alps above 1000 m altitude.This identification appeared of interest because the particular habitat of the species and the metabolic correlation between y-methyleneglutamic acid and u-methylenebutyrolactone, a highly active antimycotic substance wich is present with ''-methyleneg1utamic acid in Tulipa gesneriana, Lilium candidum and Fritillaria imperialis [15].-Methyleneglutainic acid was present as the most abundant component in roots, bulbs, leaves and petals collected in various vegetative periods (initial growth, growth, beginning of flowering, flowering). In the roots at the time of flowering it is pratically the oniy free aminoacid present. The isolation of y-methyleneglutamic acid from Lilium martagon has not been possible since the spe-Downloaded by: University of Arizona Library. Copyrighted material.

Ethno-pharmacological review on the wild edible medicinal plant, Lilium martagon L

“…Lilidine, syn. jatropham (1) (5-hydroxy-3-methyl-1, 5-dihydro-pyrrol-2-one) was isolated from the epigeal part of L. martagon in 1987 (Figure 2) [36,37]. Studies on the total alkaloid content (TAC) of L. martagon plants growing in the highmountain part of South Urals [Kuyantau (Malyi Yamantau) region] revealed values of 0.0063 -0.160 % in the aerial part, and 0.150 -0.358 % in the bulbs, with maximum TAC at the beginning of vegetation period (April) [35].…”

“…In underground and aerial parts of the plant, γmethylene glutamic acid (2) is accumulated at the highest concentration, as revealed from TLC analysis of plants at different vegetative periods (at initial growth period, during growth, at the beginning of flowering, and flowering statge) in Cuneo (Italy) in the spring-summer period [36].…”