γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis

Fang, Guihua; Wang, Qiuxiang; Yang, Xuewen; Yu, Qian; Zhang, Guowei; Tang, Bo

doi:10.1016/j.carbpol.2021.118889

Cited by 23 publications

(14 citation statements)

References 62 publications

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“…1C). 43 The crosslinking of this hydrogel primarily relies on the host-guest recognition between the PEG of Soluplus micelles and g-CDs, as well as the hydrogen bonding interactions between g-CDs. The drug flurbiprofen (FLB) was loaded into the hydrophobic core of Soluplus micelles.…”

Section: Hydrogen Bondingmentioning

confidence: 99%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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Section: Hydrogen Bondingmentioning

confidence: 99%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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“…Less than 5% of drugs have been reported to enter the aqueous humor, this result in a sub-therapeutic drug concentration in these ocular tissues [63]. To overcome this situation, it has developed polypseudorotaxane hydrogels were developed by mixing polyvinyl caprolactampolyvinyl acetate-polyethylene (Soluplus ® ) micelles about 99.4 nm and cyclodextrins solution as a prominent example [64].…”

Section: Ophthalmic Hydrogelsmentioning

confidence: 99%

Structural Strategies of Supramolecular Hydrogels and Their Applications

Sánchez-Fernández¹

2023

Preprint

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Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. These fields of scientific action include promising applications i biomedical areas, in sensing, and in conductive and electrical phases. The sensible definition of supramolecular molecules is being set by investigators, who, because of the different sensitivities of their methods and observational timescales, may have different views as to what constitute these supramolecular structures. Besides, diverse polymers can be found to offer unique avenues for multifunctional systems with properties in medicine industrial applications. Aspects of this review provide different conceptual strategies to address molecular design, properties, and potential applications of self-assembly materials and the use of metal coordination as a feasible and useful strategy for constructing complex supramolecular structures. In this order of appreciations and ideas order, it is that this review report involves classic topics such as hydrogels that range from their relationship with drug delivery systems, to metallo-supramolecular materials, through applications in ophthalmic systems, in applications that require adhesiveness and electrically conductive hydrogels. This review also addresses systems that are largely based on hydrogel chemistry and the enormous opportunities to design very specific structures for applications that demand enormous specificity.

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“…Less than 5% of drugs have been reported to enter the aqueous humor, which results in sub-therapeutic drug concentrations in these ocular tissues [ 69 ]. To overcome this situation, as a prominent example, polypseudorotaxane hydrogels were developed by mixing polyvinyl caprolactam-polyvinyl acetate-polyethylene (Soluplus ® ) micelles of approximately 99.4 nm with a cyclodextrins solution [ 70 ].…”

Section: Selected Applications Of Hydrogels Based On Supramolecular S...mentioning

confidence: 99%

Structural Strategies for Supramolecular Hydrogels and Their Applications

Sánchez-Fernández¹

2023

Polymers

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Supramolecular structures are of great interest due to their applicability in various scientific and industrial fields. The sensible definition of supramolecular molecules is being set by investigators who, because of the different sensitivities of their methods and observational timescales, may have different views on as to what constitutes these supramolecular structures. Furthermore, diverse polymers have been found to offer unique avenues for multifunctional systems with properties in industrial medicine applications. Aspects of this review provide different conceptual strategies to address the molecular design, properties, and potential applications of self-assembly materials and the use of metal coordination as a feasible and useful strategy for constructing complex supramolecular structures. This review also addresses systems that are based on hydrogel chemistry and the enormous opportunities to design specific structures for applications that demand enormous specificity. According to the current research status on supramolecular hydrogels, the central ideas in the present review are classic topics that, however, are and will be of great importance, especially the hydrogels that have substantial potential applications in drug delivery systems, ophthalmic products, adhesive hydrogels, and electrically conductive hydrogels. The potential interest shown in the technology involving supramolecular hydrogels is clear from what we can retrieve from the Web of Science.

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γ-Cyclodextrin-based polypseudorotaxane hydrogels for ophthalmic delivery of flurbiprofen to treat anterior uveitis

Cited by 23 publications

References 62 publications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Structural Strategies of Supramolecular Hydrogels and Their Applications

Structural Strategies for Supramolecular Hydrogels and Their Applications

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