γ‐Cyanooxazolines: An Interesting Synthon from Oxazoline Cyanocuprate Addition to Conjugated Cyanoalkenes.

Abstract

Oxazole derivatives R 0220 γ-Cyanooxazolines: An Interesting Synthon from Oxazoline Cyanocuprate Addition to Conjugated Cyanoalkenes. -Conjugated addition of the cuprate derived from 2,2,4-trimethyloxolane (I) to cyanoalkenes results in an efficient formation of γ-cyanooxazolines. The utility of the method is demonstrated by conversion of product (IIIc) to homobaclofen (VI). -(SIMONELLI*, F.; DE A. MARQUES, F.; WISNIEWSKI, A. J.; WENDLER, E. P.; Tetrahedron Lett. 45 (2004) 43, 8099-8101; Dep. Quim., Univ. Fed.