β2 Adrenoreceptor blockade attenuates the hyperinflammatory response induced by traumatic injury

Catecholamine Stress Alters Neutrophil Trafficking and Impairs Wound Healing by β 2 -Adrenergic Receptor–Mediated Upregulation of IL-6

“…Recent published data supports the potential role of β 2 AR in wound healing, both by modulating the pro-inflammatory response (Rough et al , 2009; Tan et al , 2007) and impairing wound re-epithelialization (Sivamani et al , 2009). Hence, we examined whether epinephrine-stress induced PMN trafficking to wound sites and impaired wound healing was mediated by a β 2 AR-dependent mechanism.…”

“…Interestingly, repeated psychosocial stress can increase the number of Ly6C hi macrophages that traffic to inflamed tissue in the brain, and chronic restraint stress similarly increases the trafficking of this pro-inflammatory macrophage phenotype to breast cancer tumors, with both of these responses blocked by an β-AR antagonist (Wohleb et al , 2011). Additionally, the role of β 2 AR signaling in modulating immunological responses has been supported by the demonstration that its activation enhances pro-inflammatory cytokines and, conversely, by the efficacy of β 2 AR blockade in attenuating the inflammatory responses in various pathological conditions including traumatic injury, burn injury, and sepsis (Rough et al , 2009). Our findings are consistent with previous demonstrations of induction of a pro-inflammatory profile of macrophages by β 2 AR activation, and extend those findings by revealing a stress/epinephrine-mediated activation of β 2 AR signaling pathway that can alter IL-6 cytokine expression in macrophages in the wound, which drive persistent PMN trafficking.…”

Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans

“…We have previously reported a decrease in the ADRB2 expression linked to the polyphenol content of olive oil within the frame of the traditional Mediterranean diet (8). In vivo studies have reported a significant decrease in MCP1 and IFN-c after an ADRB2 blockade after an operative injury in rat models (31). Thus, a complementary mechanism for a mediated IFNG CD40L downregulation could be a decrease of the ADRB2 expression mediated by olive oil polyphenols.…”

β-Blockade use for Traumatic Injuries and Immunomodulation

“…(125, 126) Reports of different cytokine profile responses to catecholamine challenge and septic insult may be due to variable catecholamine concentrations, timing of interventions, and differential α and β adrenergic stimulation. Exogenous alpha adrenergic stimulation can have either immunoenhancing or immunosuppressive effects on IgM production in vitro , depending on drug concentration.…”