β Trace protein. Purification and urinary excretion studies in selected diseases

Urinary β-trace protein

“…[3,4] β-trace protein (BTP), which is also known as lipocalin-type prostaglandin D synthase, is a small protein (23–29 kDa, depending on the different glycosylation of the molecule) isolated primarily from cerebrospinal fluid. [5–7] Like other LMWPs, BTP is taken up by tubular cells and actively degraded within their lysosomes to produce the N-terminal-truncated form. [8] Previous studies demonstrated that serum BTP (S-BTP) is an adequate marker of GFR impairment with a diagnostic accuracy similar to those of S-Cr, cystatin C, and B2M.…”