Urinary β-trace protein

Donadio, Carlo; Bozzoli, Laura

doi:10.1097/md.0000000000005553

Cited by 15 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most low molecular weight proteins, such as β 2 -microglobulin (B2M), β-trace protein (BTP), neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CYSC), are filtered by the glomerulus and reabsorbed by the proximal tubules (Table 1). While increased serum concentrations of these markers indicate glomerular damage, an increase in urinary concentrations implies tubular injury [3,9]. Uromodulin (URO) is a glycoprotein, which is exclusively produced by the cells in the thick ascending limb, and lower serum levels indicate a function decrease of these epithelial cells [10,11].…”

Section: Introductionmentioning

confidence: 99%

Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents

Donge

Staub

Atkinson

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

ObjectivesThe use of kidney function and injury markers for early detection of drug-related glomerular or tubular kidney injury in infants, children and adolescents requires age-specific data on reference intervals in a pediatric healthy population. This study characterizes serum values for eight kidney function and injury markers in healthy infants, children and adolescents.MethodsA single center prospective observational study was conducted between December 2018 and June 2019. Serum samples from 142 healthy infants, children and adolescents aged between 0 and ≤15 years were collected. Statistical analyses for eight markers (albumin (ALB), β2-microglobulin (B2M), β-trace protein (BTP), creatinine (SCR), cystatin C (CYSC), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), uromodulin (URO)) were performed to obtain reference intervals and associations with age, sex and weight were investigated (Pearson correlation, linear and piecewise regression).ResultsALB and SCR increased with age (p<0.01), whereas B2M, BTP and KIM-1 values decreased with advancing age (p<0.05) in this healthy pediatric study population. CYSC showed dependency on sex (lower concentration in females) and decreased with age until reaching approximately 1.8 years; thereafter an increase with age was seen. NGAL and URO did not show any age-dependency.ConclusionsThis study provides age appropriate reference intervals for key serum kidney function and injury markers determined in healthy infants, children and adolescents. Such reference intervals facilitate the interpretation of changes in kidney function and injury markers in daily practice, and allow early detection of glomerular and tubular injury in infancy, childhood and adolescence.

show abstract

Section: Introductionmentioning

confidence: 99%

Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents

Donge

Staub

Atkinson

et al. 2020

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

“…In addition to commonly used markers recommended by clinical practice guidelines, namely cystatin C and creatinine, several BTP-based estimated GFR formulas have been proposed in a study enrolling patients with the receipt of a kidney transplant [30]. Similar to other novel biomarkers, such as neutrophil gelatinase-associated lipocalin, BTP can be detected and measured in the blood and urine, and is also an indicator of acute and chronic renal dysfunction and renal tubular injury [31,32].…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Role of Serum β-Trace Protein Levels among Patients on Maintenance Hemodialysis

Huang,

Hsu,

Wang

et al. 2024

Diagnostics

View full text Add to dashboard Cite

Cardiovascular (CV) diseases are the most commonly encountered etiology of mortality in patients having kidney failure. β-Trace protein (BTP) is a biomarker of glomerular filtration function as well as a potential predictor of adverse CV outcomes. This study aimed to determine the prognostic value of BTP in patients on chronic hemodialysis (HD). A total of 96 patients undergoing HD were enrolled. Baseline variables were collected, and the patients were tracked for 3 years. Twenty-five patients died at 3 years. Those who experienced mortality were noted to have higher serum concentrations of BTP and a higher incidence of diabetes mellitus (DM). The area under the receiver operating characteristic curve for serum BTP distinguishing mortality from survival was 0.659 (95% confidence interval [CI], 0.555–0.752; p = 0.027). After the adjustment of variables potentially affecting survival rates, BTP levels above the median (adjusted hazard ratio [aHR]: 2.913, 95% CI, 1.256–6.754; p = 0.013), the presence of DM (aHR: 2.474, 95% CI, 1.041–5.875; p = 0.040), and low serum albumin (aHR: 0.298, 95% CI, 0.110–0.806; p = 0.017) independently correlated with survival in HD patients. Serum BTP is a novel biomarker for predicting overall outcomes in HD patients.

show abstract

“…The project will also include the collection of blood and urine samples to investigate existing and innovative biomarkers of kidney function. Existing biomarkers of CKD like Cystatin C (CysC) [ 56 ], β-Trace protein (BTP), also known as lipocalin prostaglandin D2 synthase [ 57 , 58 ] Beta2-microglobulin [ 59 ] will be measured using published and established methods. Potential and new biomarkers will be also evaluated.…”

Section: Methodsmentioning

confidence: 99%

Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study

et al. 2018

View full text Add to dashboard Cite

BackgroundDecline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016.Methods/designAn observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months- follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for ‘basic’ parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months.DiscussionCombining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people.Trial registrationThis study was registered prospectively on the 25th February 2016 at clinicaltrials.gov (NCT02691546).

show abstract

Urinary β-trace protein

Abstract: Supplemental Digital Content is available in the text

Cited by 15 publications

References 40 publications

Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents

Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents

The Prognostic Role of Serum β-Trace Protein Levels among Patients on Maintenance Hemodialysis

Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study

Contact Info

Product

Resources

About