β-sitosterol targets glucocorticoid receptor to reduce airway inflammation and remodeling in allergic asthma

Xu, Jianfeng; Yang, Lei; Lin, Tiantian

doi:10.1016/j.pupt.2022.102183

Cited by 11 publications

(2 citation statements)

References 30 publications

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“…In addition, SIT reduced the number of macrophages and neutrophils in the spleen and increased the number of NK cells and dendritic cells in peripheral blood, thereby inhibiting inflammation and improving asthma symptoms [ 232 ]. In another study of asthma, SIT improved airway inflammation and remodeling by binding to and upregulating glucocorticoid receptors, significantly suppressing type Ⅱ immune response (such as IL-25 and IL-33 secretion) and collagen deposition [ 233 ]. In the mouse model of lung chronic infection, SIT was proven to remarkably target the excessive neutrophil recruitment, thus favoring inflammation alleviation [ 234 ].…”

Section: Effects On Immunity and Inflammationmentioning

confidence: 99%

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects

Wang

Zhang

et al. 2023

Advances in Nutrition

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Section: Effects On Immunity and Inflammationmentioning

confidence: 99%

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects

Wang

Zhang

et al. 2023

Advances in Nutrition

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“…The mechanism of action responsible for this immunomodulatory activity could be associated with the affinity of beta-sitosterol to the glucocorticoid receptor (GR). The structural similarity of sitosterol to steroids and corticosteroids would explain its ability to reduce airway inflammation in in vivo models of asthma [108]. Although beta-sitosterol is not an exclusive compound of medicinal plants with immunomodulatory activity, it could act in synergy with other anti-inflammatory molecules identified in the petroleum ether extract of B. pilosa and potentiate their effects.…”

Section: The Medium-low Polarity Compounds Of the Petroleum Ether Ext...mentioning

confidence: 99%

A Bidens pilosa L. Non-Polar Extract Modulates the Polarization of Human Macrophages and Dendritic Cells into an Anti-Inflammatory Phenotype

Rodríguez Mesa,

Contreras Bolaños,

Modesti Costa

et al. 2023

Molecules

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Different communities around the world traditionally use Bidens pilosa L. for medicinal purposes, mainly for its anti-inflammatory, antinociceptive, and antioxidant properties; it is used as an ingredient in teas or herbal medicines for the treatment of pain, inflammation, and immunological disorders. Several studies have been conducted that prove the immunomodulatory properties of this plant; however, it is not known whether the immunomodulatory properties of B. pilosa are mediated by its ability to modulate antigen-presenting cells (APCs) such as macrophages (MØs) and dendritic cells (DCs) (through polarization or the maturation state, respectively). Different polar and non-polar extracts and fractions were prepared from the aerial part of B. pilosa. Their cytotoxic and immunomodulatory effects were first tested on human peripheral blood mononuclear cells (PBMCs) and phytohemagglutinin (PHA)-stimulated PBMCs, respectively, via an MTT assay. Then, the non-cytotoxic plant extracts and fractions that showed the highest immunomodulatory activity were selected to evaluate their effects on human MØ polarization and DC maturation (cell surface phenotype and cytokine secretion) through multiparametric flow cytometry. Finally, the chemical compounds of the B. pilosa extract that showed the most significant immunomodulatory effects on human APCs were identified using gas chromatography coupled with mass spectrometry. The petroleum ether extract and the ethyl acetate and hydroalcoholic fractions obtained from B. pilosa showed low cytotoxicity and modulated the PHA-stimulated proliferation of PBMCs. Furthermore, the B. pilosa petroleum ether extract induced M2 polarization or a hybrid M1/M2 phenotype in MØs and a semi-mature status in DCs, regardless of exposure to a maturation stimulus. The immunomodulatory activity of the non-polar (petroleum ether) extract of B. pilosa on human PBMC proliferation, M2 polarization of MØs, and semi-mature status in DCs might be attributed to the low–medium polarity components in the extract, such as phytosterol terpenes and fatty acid esters.

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Hispidulin targets PTGS2 to improve cyclophosphamide-induced cystitis by suppressing NLRP3 inflammasome

Liu,

Li,

Dong

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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β-sitosterol targets glucocorticoid receptor to reduce airway inflammation and remodeling in allergic asthma

Cited by 11 publications

References 30 publications

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects

β-Sitosterol as a Promising Anticancer Agent for Chemoprevention and Chemotherapy: Mechanisms of Action and Future Prospects

A Bidens pilosa L. Non-Polar Extract Modulates the Polarization of Human Macrophages and Dendritic Cells into an Anti-Inflammatory Phenotype

Hispidulin targets PTGS2 to improve cyclophosphamide-induced cystitis by suppressing NLRP3 inflammasome

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