β-Sitosterol and stigmasterol ameliorate dextran sulfate sodium-induced colitis in mice fed a high fat Western-style diet

Feng, Simin; Dai, Zhuqing; Liu, Anna; Wang, Hong; Chen, Jayson; Luo, Zisheng; Yang, Chung S.

doi:10.1039/c7fo00375g

Cited by 70 publications

(54 citation statements)

References 36 publications

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“…Some of those compounds have been proved to exhibit potent pharmacological effects. For example, stigmasterol (OB = 43.83, DL = 0.76) and kaempferol (OB = 41.88, DL = 0.24) can suppress inflammation of dextran sulfate sodium-induced colitis 23 , 24 , β -sitosterol (OB = 36.91, DL = 0.75) could inhibit TNBS-induced colitis 25 . It should be noted that Renshen contains a large amount of ginsenosides, and most of them did not meet the criteria of OB ≥30% and DL ≥0.18.…”

Section: Resultsmentioning

confidence: 99%

Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs

Feng

Yue

et al. 2018

Sci Rep

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In clinic, both synthetic drugs and Shenzhu Capsule (SZC), one kind of traditional Chinese medicines (TCMs), are used to treat ulcerative colitis (UC). In our study, a systems pharmacology approach was employed to elucidate the chemical and mechanism differences between SZC and synthetic drugs in treating UC. First, the compound databases were constructed for SZC and synthetic drugs. Then, the targets of SZC were predicted with on-line tools and validated using molecular docking method. Finally, chemical space, targets, and pathways of SZC and synthetic drugs were compared. Results showed that atractylenolide I, atractylone, kaempferol, etc., were bioactive compounds of SZC. Comparison of SZC and synthetic drugs showed that (1) in chemical space, the area of SZC encompasses the area of synthetic drugs; (2) SZC can act on more targets and pathways than synthetic drugs; (3) SZC can not only regulate immune and inflammatory reactions but also act on ulcerative colitis complications (bloody diarrhea) and prevent UC to develop into colorectal cancer whereas synthetic drugs mainly regulate immune and inflammatory reactions. Our study could help us to understand the compound and mechanism differences between TCM and synthetic drugs.

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Section: Resultsmentioning

confidence: 99%

Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs

Feng

Yue

et al. 2018

Sci Rep

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“…Formononetin, the most significant component in CSCC, is a natural isoflavone found in many Chinese medicinal herbs, such as SFR, and could offer protection against acute colitis in DSS-induced mouse models through the inhibition of cellular signaling cytokines produced by T cells in intestinal inflammation [43,44]. Licochalcone A obtained from LR attenuate DSS-induced colitis through the inhibition of NF-κB, a key factor in the increase in the number of 17 cells, and of IL-17 signaling [45,46]. Several results provide vital evidence to support the conclusion of C-T network analysis and suggest a potential mechanism underlying the effects of CSCC treatment on UC.…”

Section: Discussionmentioning

confidence: 99%

Integrating Pharmacology and Microbial Network Analysis with Experimental Validation to Reveal the Mechanism of Composite Sophora Colon‐Soluble Capsule against Ulcerative Colitis

Ding

Chen

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Ulcerative colitis (UC) has multifactorial pathogenesis that acts synergistically, such as immune system dysregulation and expansion of infectious gut microbiota. Therefore, a multicomponent treatment derived from Chinese herbal medicine that interacts with multiple targets synergistically is needed. Composite sophora colon-soluble capsule (CSCC) is a Chinese herbal formula that has shown therapeutic efficacy against UC in randomized clinical trials. However, its bioactive components and potential target genes against UC remain unclear. Here, we used a network pharmacology approach to detect component-target-pathway interactions of CSCC against UC. A total of 29 gene targets, 91 bioactive components, and 20 enriched pathways of CSCC were identified. The IL-17 signaling pathway activated by infectious gastrointestinal microbes and predicted by the network analysis to be a major pathway modulated by CSCC against UC was studied in a dextran sulfate sodium-induced colitis model. CSCC showed remarkable efficacy against UC with respect to the attenuation of colon length, body weight loss, and disease activity index through gut microbiota recovery and intestinal immune homeostasis. The rectal administration of CSCC reduced the numbers of Th17 cells isolated from both mesenteric lymph nodes and lamina propria mononuclear cells and the levels of IL-17A, IL-6, IL-1β, and TNF-α. Additionally, the percentage of Treg cells and the levels of their hallmark cytokines were upregulated. Rectal administration of CSCC led to microbiota regulation with a significant correlation between suppression of Verrucomicrobiaceae and Ruminococcaceae, as well as the elevation of Lactobacillaceae, and CSCC administration via microbiome correlation heatmaps and cooccurrence network analysis at multiple time points. Thus, our study presents an effective herbal formula, CSCC, for UC treatment and explores its components and mechanisms of efficacy through the examination of gut microbiota and hallmark cytokines in the IL-17 pathway.

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“…Stigmasterol and β-sitosterol had inhibitory effects on colitis induced by dextran sodium sulfate in C57BL/6J male mice. They critically suppressed colon shortening, colitis, and distal colon via the inactivation of NF-κB and decreased fecal hemoglobin content ( Feng et al, 2017 ). A recent study showed that β-sitosterol had an anti-inflammatory activity based on the rat pleurisy assay and rat paw edema test ( Paniagua-Pérez et al, 2017 ).…”

Section: Pharmacologymentioning

confidence: 99%

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

Zhang

Zhao

Chang

et al. 2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance Atractylodis Rhizoma (AR), mainly includes Atractylodes lancea (Thunb.) DC. ( A. lancea ) and Atractylodes chinensis (DC.) Koidz. ( A. chinensis ) is widely used in East Asia as a diuretic and stomachic drug, for the treatment of rheumatic diseases, digestive disorders, night blindness, and influenza as it contains a variety of sesquiterpenoids and other components of medicinal importance. Aim of the review A systematic summary on the botany, traditional uses, phytochemistry, pharmacology, toxicology, and quality control of AR was presented to explore the future therapeutic potential and scientific potential of this plant. Materials and methods A review of the literature was performed by consulting scientific databases including Google Scholar, Web of Science, Baidu Scholar, Springer, PubMed, ScienceDirect, CNKI, etc. Plant taxonomy was confirmed to the database “The Plant List”. Results Over 200 chemical compounds have been isolated from AR, notably sesquiterpenoids and alkynes. Various pharmacological activities have been demonstrated, especially improving gastrointestinal function and thus allowed to assert most of the traditional uses of AR. Conclusions The researches on AR are extensive, but gaps still remain. The molecular mechanism, structure-activity relationship, potential synergistic and antagonistic effects of these components need to be further elucidated. It is suggested that further studies should be carried out in the aspects of comprehensive evaluation of the quality of medicinal materials, understanding of the “effective forms” and “additive effects” of the pharmacodynamic substances based on the same pharmacophore of TCM, and its long-term toxicity in vivo and clinical efficacy.

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β-Sitosterol and stigmasterol ameliorate dextran sulfate sodium-induced colitis in mice fed a high fat Western-style diet

Cited by 70 publications

References 36 publications

Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs

Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs

Integrating Pharmacology and Microbial Network Analysis with Experimental Validation to Reveal the Mechanism of Composite Sophora Colon‐Soluble Capsule against Ulcerative Colitis

Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control

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