Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs

Feng, Wuwen; Ao, Hui; Yue, Shi‐Jun; Peng, Cheng

doi:10.1038/s41598-018-34509-1

Cited by 44 publications

(30 citation statements)

References 72 publications

(77 reference statements)

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“…Increasing evidence showed that the traditional Chinese medicines can be applied to treat UC [4]. Feng et al [5] indicated that Shenzhu Capsule contained two herbal medicines (Renshen and Baizhu) and improved UC by altering TNF signalling pathway, Toll-like receptor signalling pathway and NF-kb signalling pathway. Qingchang Wenzhong Decoction comprising of eight kinds of herbs attenuated dextran sulphate sodium-(DSS-) induced UC in rats by upregulating macrophage-stimulating protein concentration/receptor tyrosine kinase signalling pathway [6].…”

Section: Introductionmentioning

confidence: 99%

Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients

Yang

Gan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon and the rectum. Recently, some studies have shown that microorganisms in the gut play important roles in many chronic diseases such as UC. Methods. To study the candidate viruses and bacteria involved in UC and to investigate the therapeutic mechanism of Quyushengxin formula (QYSX) in UC patients, metagenomic sequencing was performed on the feces from healthy donors and UC patients before and after QYSX treatment. Results. QYSX improved the symptoms of UC. In all participants, Caudovirales and Herpesvirales were the most dominant viruses. The abundance of Caudovirales in UC patients was significantly higher than that in the normal controls, while QYSX restored Caudovirales abundance. Furthermore, the abundance of crAssphage was enhanced in UC patients compared with the normal control, while the diversity was then decreased after QYSX treatment. However, there was no significant difference (P>0.05). Additionally, other non-crAssphage bacteriophages including phiST, SP-10, and phi17:2 were higher in UC patients and QYSX decreased these viruses, while the trends of MED4−213, P-HM1, and P−HM2 were adverse. Interestingly, PhiDP23.1 was only found in UC patients before and after QYSX treatment. In addition, Bifidobacterium, Bacteroidetes, Prevotellaceae, Actinobacteria, and Corynebacteriales were the biomarkers in UC patients after QYSX treatment due to their high abundance. GO terms and KEGG analysis showed that the identified gut microbiome was involved in many biological processes and pathways. Conclusions. QYSX could regulate disordered gut microbiome and phages, indicating that QYSX has great therapeutic potential for UC.

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Section: Introductionmentioning

confidence: 99%

Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients

Yang

Gan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…In addition, SZC could reversely regulate the expression of some genes (metabolic, ion channels and transport proteins) in SGC-7901 tumor-bearing mice, resulting in the improvement of gastric cancer through multiple targets [22]. Moreover, SZC not only regulated immune and inflammatory responses during the treatment of ulcerative colitis (UC), but also acted on UC complications (bloody diarrhea) and prevented UC from developing into colorectal cancer [23]. At present, our attentions are being paid to investigate whether SZC exhibits therapeutic effect on CID, the GI side effect of chemotherapeutic drugs.…”

Section: Introductionmentioning

confidence: 99%

Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule

Wang

Feng

Zhang

et al. 2019

BMC Complement Altern Med

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Background: Gut microbiota plays a crucial role in the treatment of gastrointestinal (GI) diseases such as chemotherapy-induced diarrhea (CID). Shenzhu Capsule (SZC) is a Chinese herbal formula, which is composed of Renshen (rhizomes of Panax ginseng C. A. Mey.) and Baizhu (rhizomes of Atractylodes macrocephala Koidz.). Many Chinese traditional anti-diarrheal formulae that contain Renshen and Baizhu are capable of effectively alleviating CID. However, the efficacy in vivo and potential mechanism of SZC (the form of compatibility of Renshen and Baizhu) in the treatment of CID had not been elucidated. Here, this study aimed to investigate whether SZC exhibited the antidiarrheal activity, and whether gut microbiota was involved in the therapeutic effect of SZC on CID. Methods: High performance liquid chromatography (HPLC), gas chromatography-mass spectrometer (GC-MS) and infrared spectroscopy (IR) analyses were used to characterize the extracted components in SZC. The mice were orally administrated with SZC in a preventive mode on the first 2 days of this experiment, and then intraperitoneally injected with 5-FU (40 mg/kg/d) for 6 days. SZC treatment lasted until the 3rd day after the end of 5-FU chemotherapy. We investigated the effects of SZC on body weights, diarrhea, thymus/spleen indexes, colonic tissues, and gut microbiota. Colonic histology was examined by hematoxylin-eosin (HE) staining. 16S rDNA Amplicon Sequencing was used to analyze the gut microbial structure from fecal samples. Results: SZC significantly increased the body weights and thymus/spleen indexes, alleviated diarrhea, and reversed histopathological changes of colons. In addition, gut microbiota analysis revealed that the overall structure of gut microbiota in CID mice was disturbed, but reversed to the normal state after SZC treatment. At genus level, SZC significantly inhibited the growth of some potential pathogens associated with diarrhea, such as Clostridiumm, Bacteroides, Parabacteroides, Alloprevotella, Acinetobacter and Pseudomonas. Conclusions: In our study, these data illustrated that SZC inhibited the growth of many potential pathogens during the alleviation of CID. Gut microbial modulation was associated with the anti-diarrheal activity of SZC.

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“…proteins identied in the network based on the interaction between active ingredients and target proteins. 81 As shown in Fig. 7 and 8, molecular docking analysis showed that hydrogen bonds can form spontaneously between the 7 core compounds and the target proteins.…”

Section: Discussionmentioning

confidence: 96%

Network pharmacology-based study of the mechanisms of action of anti-diabetic triterpenoids from Cyclocarya paliurus

Zhang

Tong

et al. 2020

RSC Adv.

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Systems pharmacology reveals the unique mechanism features of Shenzhu Capsule for treatment of ulcerative colitis in comparison with synthetic drugs

Cited by 44 publications

References 72 publications

Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients

Quyushengxin Formula Causes Differences in Bacterial and Phage Composition in Ulcerative Colitis Patients

Gut microbial modulation in the treatment of chemotherapy-induced diarrhea with Shenzhu Capsule

Network pharmacology-based study of the mechanisms of action of anti-diabetic triterpenoids from Cyclocarya paliurus

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