β-N-Methyl-Amino-L-Alanine cyanotoxin promotes modification of undifferentiated cells population and disrupts the inflammatory status in primary cultures of neural stem cells

Méresse, Sarah; Larrigaldie, Vanessa; Oummadi, Asma; Concini, Vidian de; Morisset-Lopez, Séverine; Reverchon, Flora; Menuet, Arnaud; Montécot-Dubourg, Céline; Mortaud, Stéphane

doi:10.1016/j.tox.2022.153358

Cited by 3 publications

(4 citation statements)

References 89 publications

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“…The most robust upregulation was seen in IL-6, which expression has been shown to be related to hyposmia, inversely correlated with cognitive test scores, and proceeds the development of senile plaques, a hallmark of AD [72] , [73] , [74] . These findings suggest that chronic BMAA exposure to olfactory tissues may increase gene expression profiles that can cause neuroinflammation and olfactory dysfunction in susceptible individuals [75] , [76] .…”

Section: Discussionmentioning

confidence: 81%

Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer’s disease patients using UHPLC-MS/MS: An autopsy case-series study

Garamszegi¹,

Banack²,

Duque³

et al. 2023

Toxicology Reports

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Section: Discussionmentioning

confidence: 81%

Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer’s disease patients using UHPLC-MS/MS: An autopsy case-series study

Garamszegi¹,

Banack²,

Duque³

et al. 2023

Toxicology Reports

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“…We thus aimed at determining the effects of marennine on immunocompetent cell populations and activation. The activation status of these immunocompetent cells is referred to as the balance ratio between CD86 + and CD206 + [ 48 , 49 ]. Whatever marennine concentration, no harmful effect could be observed after 24 h of exposure, neither on astrocytes nor microglial cell population, at 10 or 50 µg/mL.…”

Section: Discussionmentioning

confidence: 99%

Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model

Méresse

Gâteau

Tirnan

et al. 2023

IJMS

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Haslea ostrearia, a cosmopolitan marine pennate diatom, produces a characteristic blue pigment called marennine that causes the greening of filter-feeding organisms, such as oysters. Previous studies evidenced various biological activities of purified marennine extract, such as antibacterial, antioxidant and antiproliferative effects. These effects could be beneficial to human health. However, the specific biological activity of marennine remains to be characterized, especially regarding primary cultures of mammals. In the present study, we aimed to determine in vitro the effects of a purified extract of marennine on neuroinflammatory and cell migratory processes. These effects were assessed at non-cytotoxic concentrations of 10 and 50μg/mL on primary cultures of neuroglial cells. Marennine strongly interacts with neuroinflammatory processes in the immunocompetent cells of the central nervous system, represented by astrocytes and microglial cells. An anti-migratory activity based on a neurospheres migration assay has also been observed. These results encourage further study of Haslea blue pigment effects, particularly the identification of molecular and cellular targets affected by marennine, and strengthen previous studies suggesting that marennine has bioactivities which could be beneficial for human health applications.

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“…Perinatal exposure in mice, even with low doses of BMAA, leads to neurobehavioral disturbances during the postnatal period and adulthood [ 302 ]. Moreover, BMAA modifies neuroblast organization increasing the number of neuroblasts clusters [ 303 ].…”

Section: Mechanisms Of Brain Toxicitymentioning

confidence: 99%

“…Both glial cells and neurons can uptake and accumulate BMAA, as demonstrated using a specific polyclonal antibody against BMAA [ 333 ]. BMAA induces a proinflammatory response in astrocytes and microglial cells, causing a shift in the ratio of CD86/CD206 cells [ 303 , 334 ].…”

Section: Mechanisms Of Brain Toxicitymentioning

confidence: 99%

Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases

Nugumanova

Ponomarev

Askarova

et al. 2023

Toxins

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Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, and terrestrial ecosystems. The health significance of these metabolites, which include genotoxic- and neurotoxic agents, is confirmed by continued associations between the occurrence of animal and human acute toxic events and, in the long term, by associations between cyanobacteria and neurodegenerative diseases. Major mechanisms related to the neurotoxicity of cyanobacteria compounds include (1) blocking of key proteins and channels; (2) inhibition of essential enzymes in mammalian cells such as protein phosphatases and phosphoprotein phosphatases as well as new molecular targets such as toll-like receptors 4 and 8. One of the widely discussed implicated mechanisms includes a misincorporation of cyanobacterial non-proteogenic amino acids. Recent research provides evidence that non-proteinogenic amino acid BMAA produced by cyanobacteria have multiple effects on translation process and bypasses the proof-reading ability of the aminoacyl-tRNA-synthetase. Aberrant proteins generated by non-canonical translation may be a factor in neuronal death and neurodegeneration. We hypothesize that the production of cyanopeptides and non-canonical amino acids is a more general mechanism, leading to mistranslation, affecting protein homeostasis, and targeting mitochondria in eukaryotic cells. It can be evolutionarily ancient and initially developed to control phytoplankton communities during algal blooms. Outcompeting gut symbiotic microorganisms may lead to dysbiosis, increased gut permeability, a shift in blood-brain-barrier functionality, and eventually, mitochondrial dysfunction in high-energy demanding neurons. A better understanding of the interaction between cyanopeptides metabolism and the nervous system will be crucial to target or to prevent neurodegenerative diseases.

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β-N-Methyl-Amino-L-Alanine cyanotoxin promotes modification of undifferentiated cells population and disrupts the inflammatory status in primary cultures of neural stem cells

Cited by 3 publications

References 89 publications

Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer’s disease patients using UHPLC-MS/MS: An autopsy case-series study

Detection of β-N-methylamino-l-alanine in postmortem olfactory bulbs of Alzheimer’s disease patients using UHPLC-MS/MS: An autopsy case-series study

Haslea ostrearia Pigment Marennine Affects Key Actors of Neuroinflammation and Decreases Cell Migration in Murine Neuroglial Cell Model

Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases

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