β-Glucogallin isolated from Fusidium coccineum and its enhancement of skin barrier effects

Abstract

Soil has been used for treatment of wound and skin diseases and for cosmetic purposes. Fusidium coccineum (FC) SA-1FC (Ascomycota) is a fungus found in nature, and its by-products are present in humid soils with plant humus. This study investigates the medium of fermented FC as a covering for all skin problems, including dryness, inflammation, and wounds. A preliminary study revealed that an alcohol extract of FC had a skin-enhancing effect, and thin-layer chromatography revealed a major component in a non-polar fraction. Here we identify a major compound isolated from a non-polar fraction as β-glucogallin. The mRNA levels of filaggrin and HAS3 are upregulated by FC and β-glucogallin treatment in keratinocytes and immortalized human keratinocytes cells. In addition, FC and β-glucogallin exert anti-inflammatory effects by suppressing expression of interleukin-4/poly(I:C)-induced chemokines and inflammatory cytokines. In fibroblasts, Hs68 cells, FC and β-glucogallin stimulate cell migration. These results suggest that FC and β-glucogallin can enhance skin barrier function.

Investigation on the Phytochemical Composition, Antioxidant and Enzyme Inhibition Potential of Polygonum Plebeium R.Br: A Comprehensive Approach to Disclose New Nutraceutical and Functional Food Ingredients

“…Lyoniresinol 9′‐sulfate is previously isolated from Polygonum cuspidatum as bioactive phenolic compound [20] . Other detected phenolics are also known strong antioxidant compounds [21–23] . Besides, gingerol is the main bioactive compound in ginger [24] which is responsible for much of ginger's medicinal properties; it also possesses anti‐inflammatory and antioxidant potential [25,26] .…”

Novel Emblica officinalis extract containing β-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia

“…32 BGG has also been reported to enhance skin barrier function paving the way for its applications in cosmetics. 33 This study is perhaps the first to evaluate the clinical efficacy and safety of a standardized extract containing 10% BGG along with hydrolyzable tannins. BGG was reported to be the major component isolated from E. officinalis fruits showing potent inhibition of human aldose reductase implicated in the development of secondary complications of diabetes.…”

“…32 BGG has also been reported to enhance skin barrier function paving the way for its applications in cosmetics. 33…”

Glucogallin Attenuates the LPS-Induced Signaling in Macrophages and Protects Mice against Sepsis

“…β–glucogallin (1-O-galloyl-β-d-glucopyranose), a plant-derived polyphenolic ester, is believed to protect due to its free radical scavenging property against several diseases like diabetes, glaucoma, hepatic damage, skin damage from UV, etc. [ 4 , 5 , 6 , 26 ]. It also upregulates anti-oxidant enzymes GSH, CAT, and SOD and acts as an aldose reductase inhibitor.…”