1984
DOI: 10.1002/jez.1402320213
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β‐Endorphins (β‐EP) in amphibians: Higher β‐EP levels during regenerating stages of anuran life cycle and immunocytochemical localization of β‐EP in regeneration blastemata

Abstract: Plasma beta-endorphin (beta-EP) levels were measured at different stages of metamorphosis in anuran species, namely Rana catesbeiana, R. pipiens, and Xenopus laevis. The mean levels of beta-EP in tadpoles and postmetamorphic juveniles were significantly higher than adult levels in all three species examined. The pattern of high tadpole levels and low adult levels corresponds with the limb regeneration ability of the tadpole and restriction in the adult. We have also reported plasma beta-EP levels in two urodel… Show more

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Cited by 14 publications
(2 citation statements)
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“…DAGLB catalyzes the conversion of DAG to 2-AG. This endocannabinoid is required for axonal growth during development and thus may play a role in nerve regeneration but its up regulation is also consistent with previous studies showing an increase in endorphins after amputation of adult newt limbs, suggesting its involvement in pain control during blastema formation [128-130]. DAGLB was not detected in the Xenopus limb.…”
Section: Resultssupporting
confidence: 88%
“…DAGLB catalyzes the conversion of DAG to 2-AG. This endocannabinoid is required for axonal growth during development and thus may play a role in nerve regeneration but its up regulation is also consistent with previous studies showing an increase in endorphins after amputation of adult newt limbs, suggesting its involvement in pain control during blastema formation [128-130]. DAGLB was not detected in the Xenopus limb.…”
Section: Resultssupporting
confidence: 88%
“…4). The pattern of high tadpole levels and low adult levels corresponds with the regeneration ability of the tadpole and restriction in the adult, respectively (40).…”
Section: Efsects Of Ins On Cultured Blastemamentioning
confidence: 98%