β-Cyclodextrin polymer brushes decorated magnetic colloidal nanocrystal clusters for the release of hydrophobic drugs

Temperature-switched controlled release nanosystems based on molecular recognition and polymer phase transition

“…4b). The adsorption bands for Fe 3 O 4 -Br at the peak of 1706 cm À1 is attributed to the C]O stretching vibrations of O]C-N group in BiBB, 56,62 indicating the successful immobilization of Br atoms on the MCNCs surface (Fig. 4c).…”

“…Similar phenomena are also observed in b-CD polymers-functionalized MCNCs without PNIPAM moieties in our recent work. 56 Moreover, slight aggregation among the Fe 3 O 4 @PNG-1 or Fe 3 O 4 @PNG-1-CD NPs are observed due to the incorporation of hydrophilic PNIPAM and b-CD moieties into the graing chains on the MCNCs surface. [56][57][58][59][60] Hydrodynamic diameters and size distributions of the Fe 3 O 4 -Br, Fe 3 O 4 @PNG-1 and Fe 3 O 4 @PNG-1-CD samples were studied by DLS at 25 C and shown in Fig.…”

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

“…The loading experiment is a dynamic equilibrium process. 41 In an acidic or basic environment, the lower or higher pH could cause high degree of protonation of DOX and EPI, resulting in the partial dissociation of hydrogen bonding 42,43 and the loading capacity is not behaving well. At pH 7.0, multiple strong hydrogenbonding interactions between -OH, -COOH in MGC and -OH, -NH 2 in drugs are conducive to the incorporation of MGC and drugs, leading to a rapid increase of loading amount.…”

Co-delivery of 5-fluorouracil and miRNA-34a mimics by host-guest self-assembly nanocarriers for efficacious targeted therapy in colorectal cancer patient-derived tumor xenografts

“…5-FU is an effective chemotherapeutic drug for treating a variety of cancers, including liver cancer, breast cancer and CRC 42 . 5-FU can be effectively loaded into TCP1-CD-QD nanocarriers by self-assembly with CD 43 . First, we found that the LC and EE of 5-FU by TCP1-CD-QD nanocarriers were approximately at 6.4% and 25.8%, respectively.…”