Temperature-switched controlled release nanosystems based on molecular recognition and polymer phase transition

Lv, Shaonan; Cheng, Chang-Jing; Song, Yaya; Zhao, Zhigang

doi:10.1039/c4ra11075g

Cited by 22 publications

(23 citation statements)

References 65 publications

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“…These nanocarriers are a class of smart nano-systems with the ability to maintain their structure after stimulation. According to this feature, several species of nano-systems had been introduced by researchers in which extrinsic (UV and magnetic) or intrinsic (pH, redox and temperature) stimuli agents were used 39,63–65…”

Section: Discussionmentioning

confidence: 99%

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

Zarepour

Zarrabi

Larsen

2019

IJN

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Background Fabrication of a smart drug delivery system that could dramatically increase the efficiency of chemotherapeutic drugs and reduce the side effects is still a challenge for pharmaceutical researchers. By the emergence of nanotechnology, a huge window was opened towards this goal, and a wide type of nanocarriers were introduced for delivering the chemotherapeutic to the cancer cells, among them are cyclodextrins with the ability to host different types of hydrophobic bioactive molecules through inclusion complexation process. Aim The aim of this study is to design and fabricate a pH-responsive theranostic nanocapsule based on cyclodextrin supramolecular nano-structure. Materials and methods This nanostructure contains iron oxide nanoparticles in the core surrounded with three polymeric layers including polymeric β-cyclodextrin, polyacrylic acid conjugated to sulfadiazine, and polyethylenimine functionalized with β-cyclodextrin. Sulfadiazine is a pH-responsive hydrophobic component capable of making inclusion complex with β-cyclodextrin available in the first and third layers. Doxorubicin, as an anti-cancer drug model, was chosen and the drug loading and release pattern were determined at normal and acidic pH. Moreover, the biocompatibility of the nanocapsule (with/without drug component) was examined using different techniques such as MTT assay, complement activation, coagulation assay, and hemolysis. Results The results revealed the successful preparation of a spherical nanocapsule with mean size 43±1.5 nm and negatively charge of −43 mV that show 160% loading efficacy. Moreover, the nanocapsule has an on/off switching release pattern in response to pH that leads to drug released in low acidic pH. The results of the biocompatibility tests indicated that this nano drug delivery system had no effect on blood and immune components while it could affect cancer cells even at very low concentrations (0.3 μg mL −1 ). Conclusion The obtained results suggest that this is a “switchable” theranostic nanocapsule with potential application as an ideal delivery system for simultaneous cancer diagnosis and therapy.

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Section: Discussionmentioning

confidence: 99%

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

Zarepour

Zarrabi

Larsen

2019

IJN

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“…Furthermore, multi-responsive PDMPI exploiting a combination of changes in pH and temperature were used for separation of antibodies, [66] recycling of Cd-ions, [67] extraction of bisphenol A [68] , and uptake and release of trivalent lanthanum ions [69] and therapeutic drugs. [70] It was also demonstrated that alternation of the response of PDMPI to external stimuli due to binding of ligand molecules to PDMPI could find applications for sensor technology. For example, specially designed two-component mixed layers of tethered polymer chains, where majority chains are intermingled with labeled-with-adsorption-active-site minority chains, may undergo the first-order phase transition of the adsorption-active minority chains upon external stimuli.…”

Section: Adsorptionmentioning

confidence: 99%

Preprogrammed Dynamic Microstructured Polymer Interfaces

Tokarev

Minko

2019

Adv Funct Materials

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The advancement of new-generation complex integrated responsive systems depends on the progress in the development of functional stimuli-responsive polymer components that could be put together and engineered to perform in concert as an ensemble. This progress report highlights recent substantial progress in the development of such soft-matter components capable of changes according to preprogrammed scenarios. The components interact via interfaces that play a key role in the performance of the microstructured materials. The list of the most important properties that can be changed by altering the interfaces upon external stimuli includes gating, transport, release, wetting, adhesion, and self-regeneration (healing) realized in different architectures of soft stimuli-responsive materials.

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“…This temperature difference can be applied in temperature-responsive drug delivery to tumors. Lv et al 23 developed a novel polymer system for intelligent drug release; the developed system is based on molecular recognition and phase transition temperature response ( Figure 2 ). In their nanoparticle drug delivery system, magnetic Fe 3 O 4 colloidal nanocrystal clusters (MCNCs) are used as the core, and poly (N-isopropylacrylamide) is used as a communication bridge between MCNCs and β-cyclodextrin (β-CD).…”

Section: Tumor Targeting By Nanoparticlesmentioning

confidence: 99%

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

Xin

Yin

Zhao

et al. 2017

Cancer Biology & Medicine

222

103

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The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years.

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Temperature-switched controlled release nanosystems based on molecular recognition and polymer phase transition

Abstract: Novel temperature-switched controlled release nanosystems based on molecular recognition of β-CD and thermosensitivity of PNIPAM phase transition of is developed.

Cited by 22 publications

References 65 publications

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

<p>Fabricating β-cyclodextrin based pH-responsive nanotheranostics as a programmable polymeric nanocapsule for simultaneous diagnosis and therapy</p>

Preprogrammed Dynamic Microstructured Polymer Interfaces

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

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