β-Cyclodextrin-crosslinked alginate gel for patient-controlled drug delivery systems: regulation of host–guest interactions with mechanical stimuli

Abstract

Macroscopic mechanical force has attracted much attention as an existing yet novel energy source for modification of molecular interactions and molecular reactivity. Although various molecular level phenomena have been controlled by using macroscopic mechanical forces, control of host-guest inclusion has not been a research target. Here we report a novel controlled release system triggered by a mechanical stimulus. Release of ondansetron (ODN), an anti-emetic drug, from a designer hydrogel composed of a b-cyclodextrin (CyD) derivative and alginate (AL) can be controlled by mild mechanical compressions that mimic operation by a patient's hand. ODN is released in response to mechanical compressions by changing the inclusion ability of CyD moieties, which may be conformationally distorted, and/or suppressed stabilization of the inclusion complex when an external stress is applied. It is revealed that the release can be induced even by the slight conformational restriction for b-CyD due to the mechanical stimulus. This controlled release technology provides a novel dosing strategy enabling ondemand administration of medicines through a mechanical stimulus generated intentionally by the patient.

In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels

“…Bibby et al 66 reported a crosslinking between CD and polymeric formulations which resulted in a decrease in the polymer mesh size, thus decreasing drug release. Izawa et al 67 designed a unique system for controlled release of ondansetron which was composed of β-CD crosslinked with alginate as the main chain polymer. Many authors reported the advantages of using β-CD and chitosan together in controlling drug release from polymeric matrices.…”

Functional Nanomaterials Prepared by Nanoarchitectonics-Based Supramolecular Assembly

“…The molecular machine can catch and release guest molecules based on hand-motion-like microscopic motions. Similarly, control of molecular phenomena including chiral recognition [48,49], nucleic acid base discrimination [50], glucose detection by indicator displacement assay [51], and controllable drug delivery [52] by macroscopic mechanical motions have been demonstrated using interfacial media and related structures. These are realistic examples of accessing molecular-level functions from the macroscopic world.…”

Properties and current applications of bacterial cyclic β-glucans and their derivatives

“…The thermodynamic benefits originate from the lower Gibbs free energy for those complexes [32]. In addition, various applications related to the increased aqueous solubility [33], controlled delivery [34], sensing [35], and separation tools could be reported on the basis of host-guest chemistry [36]. In this review, an overview of history, biosynthesis, purification, structure, classification, properties, and current applications of cyclic b-glucans and their derivatives as a new family of carbohydrate hosts will be presented.…”