β-Cyclodextrin-Bearing Gold Glyconanoparticles for the Development of Site Specific Drug Delivery Systems

Abstract

Three novel gold nanoparticles containing multiple long, flexible linkers decorated with lactose, β-cyclodextrin, and both simultaneously have been prepared. The interaction of such nanoparticles with β-d-galactose-recognizing lectins peanut agglutinin (PNA) and human galectin-3 (Gal-3) was demonstrated by UV-vis studies. Gal-3 is well-known to be overexpressed in several human tumors and can act as a biorecognizable target. This technique also allowed us to estimate their loading capability toward the anticancer drug methotrexate (MTX). Both results make these glyconanoparticles potential site-specific delivery systems for anticancer drugs.

Rational Design of Multifunctional Gold Nanoparticles via Host–Guest Interaction for Cancer-Targeted Therapy

“…For instance, cyclodextrin-modified gold nanoparticles have been applied to construct versatile platform via host−guest interaction for targeted drug delivery conveniently. 31,32 Herein, a multifunctional nanocomposite based on β-cyclodextrin-modified gold nanoparticle (AuNP@CD) was delicately designed and fabricated for cancer-targeted therapy with intracellular pH-triggered drug delivery. As shown in Scheme 1, the peptidic derivative adamantane−PEG 8 −glycine− arginine−glycine−aspartic−serine (AD-PEG 8 -GRGDS) and the adamantane conjugated anticancer drug doxorubicin with hydrazone bond linkage (AD-Hyd-DOX) were decorated on the surface of AuNP@CD via host−guest interaction simultaneously, forming multifunctional nanocomposite AuNP@CD-AD-DOX/RGD.…”

Multivalent Lactose–Ferrocene Conjugates Based on Poly(Amido Amine) Dendrimers and Gold Nanoparticles as Electrochemical Probes for Sensing Galectin-3

“…Compounds 2 [36], 3[31,32], 15 [36] and 16 [36] were synthesized as previously reported. Human galectin-3 was expressed and purified as previously reported [45].…”

Glyco-gold nanoparticles: synthesis and applications

“…Despite the most common carriers are based on nano- and microparticles (i.e., albumin, poly(lactic- co -glycolic acid)-PLGA NPs, liposomes), many examples in literature report on the development of gold-based glyco nanoparticles as efficient system to delivery payloads. In this contest, AuNPs modified with lactose moieties and β-cyclodextrins have been reported by Vargas-Berenguel et al [87]. The authors showed that GAuNPs were still able to recognize specific lectin (peanut agglutinin, PNA) and human galectin-3 (Gal-3), exploiting multiple lactose residues displayed on gold surface.…”