β-Cyclodextrin based pH and thermo-responsive biopolymeric hydrogel as a dual drug carrier

Roy, Arpita; Maity, Pintu; Bose, Anirbandeep; Dhara, Santanu; Pal, Sagar

doi:10.1039/c8qm00452h

Cited by 44 publications

(30 citation statements)

References 49 publications

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“…More recently, N-isopropylacrylamide (NIPAM), itaconamic acid (AIM) and β-cyclodextrin (β-CD) were copolymerized to get a polymer which aqueous solutions showed responsiveness to temperature and pH provided by NIPAM and AIM, respectively, and additional capability to encapsulate drug molecules due to β-CD moieties (Rwei et al, 2016). Similar results were also published by Roy et al (2019) that developed pH-and thermo-responsive gels by grafting and crosslinking PNIPAM and poly(methacrylic acid) on β-cyclodextrins for preferential release of metronidazole and ofloxacin at colonic pH (i.e., 7.4) instead of stomach pH (acid pH). As an alternative to this approach, pH-sensitive release of a cargo can be also achieved by blending hydrogelforming materials with pH-sensitive polymers.…”

Section: Introductionsupporting

confidence: 60%

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Boffito

Torchio

Tonda‐Turo

et al. 2020

Front. Bioeng. Biotechnol.

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Hybrid Hydrogels for pH-Triggered Release in rodents. Moreover, MSN-CS-SIP-Ru-loaded gels turned out to be detectable through the skin by IVIS imaging. Cargo acid pH-triggered delivery from PEU-Boc and PEU-NH 2 gels was finally demonstrated through drug release tests in neutral and acid pH environments (in acid pH environment approximately 2-fold higher cargo release). Additionally, acid-triggered payload release from PEU-NH 2 gels was significantly higher compared to PEU-Boc systems at 3 and 4 days incubation. The herein designed hybrid injectable formulations could thus represent a significant step forward in the development of multi-stimuli sensitive drug carriers. Indeed, being able to adapt their behavior in response to biochemical cues from the surrounding physio-pathological environment, these formulations can effectively trigger the release of their payload according to therapeutic needs.

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Section: Introductionsupporting

confidence: 60%

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Boffito

Torchio

Tonda‐Turo

et al. 2020

Front. Bioeng. Biotechnol.

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“…[ 41 ] After radical polymerization, we found additional peaks at 40 and 177 ppm, corresponding to the sp 3 carbons and carbonyl carbons in the AAm‐based network, respectively (Figure S2, Supporting Information). [ 49 ] The FT‐IR spectrum of the CDP exhibited the complete disappearance of the stretching band of the isocyanate group at 2256 cm −1 , and the new stretching band of the carbonyl group of the urethane bond at 1630 cm −1 , which supports the condensation reaction between β‐CD and 1,4‐PDI. [ 50 ] The characteristic bands of β‐CD at 1026 and 3300 cm −1 remained in the CDP and CDPs‐HIPE spectra, indicating the inclusion of CDP during radical polymerization (Figure S3, Supporting Information).…”

Section: Resultsmentioning

confidence: 81%

Designing Internal Hierarchical Porous Networks in Polymer Monoliths that Exhibit Rapid Removal and Photocatalytic Degradation of Aromatic Pollutants

Kim

Chang

2020

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This paper describes the preparation of 3D polymer monoliths containing internal hierarchical porosity. The porous networks are fabricated based on Pickering high‐internal‐phase emulsions (HIPEs) stabilized by microporous β‐cyclodextrin‐based polymer particles (CDPs) as the emulsifier; CDPs are facilely synthesized by the polyaddition reactions without the need for catalysts. The designed Pickering agents enable to form a bicontinuous internal phase in 8:2 cyclohexane–water v/v, and the oil droplets in the continuous water phase is found to be fairly stable up to 1 month. Furthermore, the addition of acrylamide and N,N'‐methylenebis(acrylamide) results in polymer networks after in situ thermal polymerization at 60 °C in the water phase, and the monoliths include both interconnected macropores from the HIPE template and micro‐ and mesopores from the CDPs embedded at the interface. The porous monoliths rapidly absorb a variety of solvents taking advantage of multiscale porosity and amphiphilicity. Furthermore, the materials can be efficiently used for the removal of aromatic pollutants and then reused after washing and drying without the deterioration of performance. Also, they exhibit high photocatalytic capability and good recyclability as being used as a catalytic support when embedded with titanium dioxide (TiO2).

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“…[ 212 ] Very recently, simultaneously polymerization and grafting of NIPAM and methacrylic acid as well as ethylene glycol diacrylate (EGDA) moieties on pristine β ‐CD induced by azobisisobutyronitrile were achieved, the resulting pH and thermo‐responsive hydrogels exhibited noncytotoxic nature toward MG‐63 cell lines. [ 213 ]…”

Section: Synthesis Of Polysaccharide‐based Hydrogelsmentioning

confidence: 99%

Recent advances in polysaccharide‐based hydrogels for synthesis and applications

Lin

2021

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141

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Hydrogels are three‐dimensional (3D) crosslinked hydrophilic polymer networks that have garnered tremendous interests in many fields, including water treatment, energy storage, and regenerative medicine. However, conventional synthetic polymer hydrogels have poor biocompatibility. In this context, polysaccharides, a class of renewable natural materials with biocompatible and biodegradable properties, have been utilized as building blocks to yield polysaccharide‐based hydrogels through physical and/or chemical crosslinking of polysaccharides via a variety of monomers or ions. These polysaccharide‐derived hydrogels exhibit peculiar physicochemical properties and excellent mechanical properties due to their unique structures and abundant functional groups. This review focuses on recent advances in synthesis and applications of polysaccharide‐based hydrogels by capitalizing on a set of biocompatible and biodegradable polysaccharides (i.e., cellulose, alginate, chitosan, and cyclodextrins [CDs]). First, we introduce the design and synthesis principles for crafting polysaccharide‐based hydrogels. Second, polysaccharide‐based hydrogels that are interconnected via various crosslinking strategies (e.g., physical crosslinking, chemical crosslinking, and double networking) are summarized. In particular, the introduction of noncovalent and/or dynamic covalent interactions imparts polysaccharide‐based hydrogels with a myriad of intriguing performances (e.g., stimuli–response and self‐recovery). Third, the diverse applications of polysaccharide‐based hydrogels in self‐healing, sensory, supercapacitor, battery, drug delivery, wound healing, tissues engineering, and bioimaging fields are discussed. Finally, the perspectives of polysaccharide‐based hydrogels that promote their future design to enable new functions and applications are outlined.

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β-Cyclodextrin based pH and thermo-responsive biopolymeric hydrogel as a dual drug carrier

Abstract: Herein, a novel biocompatible and stimuli-responsive network gel has been developed by grafting and crosslinking poly(N-isopropyl acrylamide) and poly(methacrylic acid) on cyclic oligosaccharide β-cyclodextrin [β-CD-cl-(PNIPAm-co-PMAc)].

Cited by 44 publications

References 49 publications

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Designing Internal Hierarchical Porous Networks in Polymer Monoliths that Exhibit Rapid Removal and Photocatalytic Degradation of Aromatic Pollutants

Recent advances in polysaccharide‐based hydrogels for synthesis and applications

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