Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Abstract

Hybrid Hydrogels for pH-Triggered Release in rodents. Moreover, MSN-CS-SIP-Ru-loaded gels turned out to be detectable through the skin by IVIS imaging. Cargo acid pH-triggered delivery from PEU-Boc and PEU-NH 2 gels was finally demonstrated through drug release tests in neutral and acid pH environments (in acid pH environment approximately 2-fold higher cargo release). Additionally, acid-triggered payload release from PEU-NH 2 gels was significantly higher compared to PEU-Boc systems at 3 and 4 days incubation. The herein designed hybrid injectable formulations could thus represent a significant step forward in the development of multi-stimuli sensitive drug carriers. Indeed, being able to adapt their behavior in response to biochemical cues from the surrounding physio-pathological environment, these formulations can effectively trigger the release of their payload according to therapeutic needs.

Designing Multifunctional Devices for Regenerative Pharmacology Based on 3D Scaffolds, Drug-Loaded Nanoparticles, and Thermosensitive Hydrogels: A Proof-of-Concept Study

“…The poly(ester urethane) forming the nanoparticles most likely interacted with the polymeric chains forming the hydrogel through hydrogen bonds, which co-participate together with hydrophobic forces to micelle nucleation and aggregation [ 24 , 58 ]. A similar behavior was also observed in poly(ether urethane)-based hydrogels loaded with silica-particles coated with a pH-sensitive self-immolative polymer [ 59 ].…”

Mesoporous Bioactive Glasses Incorporated into an Injectable Thermosensitive Hydrogel for Sustained Co-Release of Sr2+ Ions and N-Acetylcysteine

“…The as-synthesized NHP was then subjected to a Boc-deprotection reaction, leading to the exposure of free primary amines along the polymeric chains. The deprotection reaction was conducted in acidic conditions according to our recently optimized protocol (Figure S2) [27]. Briefly, 10 g of NHP were first solubilized in 225 mL of chloroform at 250 rpm and RT for 120 min.…”

Sol-gel: Uncomplicated, routine and affordable synthesis procedure for utilization of composites in drug delivery: Review

“…The processing parameters were observed to affect the unloaded silica particles' porous nature, the silica particle release qualities filled with bovine serum albumin (BSA), and encapsulated and released protein structural status significantly. Boffito et al [98] suggested a different approach to this complex objective by mixing mesoporous SiO 2 nanoparticles coated with a pH acid-sensitive self-immolating polymer (MSN-CS-SIP) with custom-made amphiphilic poly (ether urethane)s (PEUs) based thermo-sensitive hydrogels. The hybrid injectable compositions developed in this way could constitute a significant step in producing drug carriers that are responsive to multi-stimuli.…”