β-Cyclodextrin as carrier of novel antioxidants: A structural and efficacy study

Chatzidaki, Maria D.; Kostopoulou, Ioanna; Kourtesi, Chryssa; Pitterou, Ioanna; Avramiotis, S.; Xenakis, Aristotelis; Detsi, Anastasia

doi:10.1016/j.colsurfa.2020.125262

Cited by 12 publications

(5 citation statements)

References 57 publications

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“…The melting of tyrosol cannot be observed in this curve, yet the decrease of the temperature of water loss, compared to the one of the pure βCD, may be evidence of the protection that the carrier offers to the molecule. This is in accordance with what has previously been reported when encapsulating a molecule in βCD [ 37 , 39 ].…”

Section: Resultssupporting

confidence: 93%

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Encapsulation of the Natural Product Tyrosol in Carbohydrate Nanosystems and Study of Their Binding with ctDNA

et al. 2020

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Tyrosol, a natural product present in olive oil and white wine, possesses a wide range of bioactivity. The aim of this study was to optimize the preparation of nanosystems encapsulating tyrosol in carbohydrate matrices and the investigation of their ability to bind with DNA. The first encapsulation matrix of choice was chitosan using the ionic gelation method. The second matrix was β-cyclodextrin (βCD) using the kneading method. Coating of the tyrosol-βCD ICs with chitosan resulted in a third nanosystem with very interesting properties. Optimal preparation parameters of each nanosystem were obtained through two three-factor, three-level Box-Behnken experimental designs and statistical analysis of the results. Thereafter, the nanoparticles were evaluated for their physical and thermal characteristics using several techniques (DLS, NMR, FT-IR, DSC, TGA). The study was completed with the investigation of the impact of the encapsulation on the ability of tyrosol to bind to calf thymus DNA. The results revealed that tyrosol and all the studied systems bind to the minor groove of ctDNA. Tyrosol interacts with ctDNA via hydrogen bond formation, as predicted via molecular modeling studies and corroborated by the experiments. The tyrosol-chitosan nanosystem does not show any binding to ctDNA whereas the βCD inclusion complex shows analogous interaction with that of free tyrosol.

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Section: Resultssupporting

confidence: 93%

“…In the chitosan DSC thermogram, in the studied range, only the loss of water is observed at the temperature range 85–107 °C, with a peak at 94 °C corresponding to the loss of water. The loss of water from cyclodextrin occurs in the range 98–155 °C with an endothermic peak at 131 °C [ 37 , 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of the Natural Product Tyrosol in Carbohydrate Nanosystems and Study of Their Binding with ctDNA

et al. 2020

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“…Nevertheless, a plenty of disadvantages restrict biomedical applications, namely low biocompatibility of the metal-based nanomaterials, low bioavailability of hydrophobic small-molecule compounds, and easy degradation of antioxidant peptides by proteases. The combination of liposomes or polymers with different payload materials has been reported, for example, PEG-modified liposomes loaded with resveratrol, layer-by-layer-coated gelatin nanoparticles, or Gelucire-based solid lipid and polymeric micelles [14][15][16][17][18][19]. However, low loading efficiency, systemic toxicity, and tedious preparation processes hinder biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Ma¹,

Gong²,

Ogino³

et al. 2022

Beilstein J. Nanotechnol.

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Oxidative stress can lead to permanent and irreversible damage to cellular components and even cause cancer and other diseases. Therefore, the development of antioxidative reagents is an important strategy to alleviate chronic diseases and maintain the redox balance in cells. Small-molecule bioactive compounds have exhibited huge therapeutic potential as antioxidants and anti-inﬂammatory agents. Myricetin (Myr), a well-known natural flavonoid, has drawn wide attention because of its high antioxidant, anti-inflammatory, antimicrobial, and anticancer efficacy. Especially regarding antioxidation, Myr is capable of not only chelating intracellular transition metal ions for removing reactive oxygen species, but also of activating antioxidant enzymes and related signal pathways and, thus, of sustainably scavenging radicals. However, Myr is poorly soluble in water, which limits its bioavailability for biomedical applications, and even its clinical therapeutic potential. The antioxidant peptide glutathione (GSH) plays a role as antioxidant in cells and possesses good hydrophilicity and biocompatibility. However, it is easily metabolized by enzymes. To take advantages of their antioxidation activity and to overcome the abovementioned limitations, GSH, Zn2+, and Myr were selected to co-assemble into Myr-Zn2+-GSH nanoparticles or nanoarchitectonics. This study oﬀers a new design to harness stable, sustainable antioxidant nanoparticles with high loading capacity, high bioavailability, and good biocompatibility as antioxidants.

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“…However, as the time exceeded 75 min, the DPPH clearance in the GO group stopped increasing while CD-GO continued to increase until it reached 70.22% DPPH clearance at 120 min, which was 17.57% higher than GO at 1.32 times the DPPH clearance rate of GO. Existing studies have shown that β-CD alone is not reductive ( 48 ), so the reason why CD-GO is more reductive than GO may be that the reducing sulfide component of GO is encapsulated by CD, increasing its solubility and stability, and preventing its volatilization or deactivation. CD-GO, there-fore, exhibits a sustained antioxidant capacity compared to GO.…”

Section: Resultsmentioning

confidence: 99%

Characterization of garlic oil/β-cyclodextrin inclusion complexes and application

Li,

Chen,

Liu

et al. 2023

Front. Nutr.

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Garlic oil is a liquid extracted from garlic that has various natural antibacterial and anti-inflammatory properties and is believed to be used to prevent and treat many diseases. However, the main functional components of garlic oil are unstable. Therefore, in this study, encapsulating garlic oil with cyclodextrin using the saturated co-precipitation method can effectively improve its chemical stability and water solubility and reduce its characteristic odor and taste. After preparation, the microcapsules of garlic oil cyclodextrin were characterized, which proved that the encapsulation was successful. Finally, the results showed that the encapsulated garlic oil still had antioxidant ability and slow-release properties. The final addition to plant-based meat gives them a delicious flavor and adds texture and mouthfeel. Provided a new reference for the flavor application of garlic cyclodextrin micro-capsules in plant-based meat patties.

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β-Cyclodextrin as carrier of novel antioxidants: A structural and efficacy study

Cited by 12 publications

References 57 publications

Encapsulation of the Natural Product Tyrosol in Carbohydrate Nanosystems and Study of Their Binding with ctDNA

Encapsulation of the Natural Product Tyrosol in Carbohydrate Nanosystems and Study of Their Binding with ctDNA

Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals

Characterization of garlic oil/β-cyclodextrin inclusion complexes and application

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