β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

Park, Kyung-Ran; Nam, Dongwoo; Yun, Hyung-Mun; Lee, Seok-Geun; Jang, Hyeung-Jin; Sethi, Gautam; Cho, Somi K.; Ahn, Kwang Seok

doi:10.1016/j.canlet.2011.08.001

Cited by 310 publications

(218 citation statements)

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“…β-caryophyllene has been atribuited to inhibit growth of cell lines and induce apoptosis in limphoma and neuroblastoma, through ROSmediated and cascade of mitogen-activated protein kinases (MAPKs) inhibition (Park et al 2011). Extracts with α-caryophyllene showed cytotoxic activity in murine macrophage RAW264.7 and colon cancer at IC 50 73.3 μg mL -1 (El Hadri et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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Salvia offi cinalis (Lamiaceae) has been used in south of Brazil as a diary homemade, in food condiment and tea-beverage used for the treatment of several disorders. The objective of this study was to characterize chemical compounds in the hydroalcoholic (ExtHS) and aqueous (ExtAS) extract from Salvia offi cinalis (L.) by gas chromatography-mass spectrometry (GC-MS) and by high-resolution electrospray ionization mass spectrometry (ESI-QTOF MS/MS), evaluate in vitro ability to scavenge the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH • ) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS •+ ), catalase (CAT-like) and superoxide dismutase (SOD-like) activity, moreover cytotoxic by MTT assay, alterations on cell morphology by giemsa and apoptotic-induced mechanism for annexin V/propidium iodide. Chemical identifi cation sage extracts revealed the presence of acids and phenolic compounds. In vitro antioxidant analysis for both extracts indicated promising activities. The cytotoxic assays using tumor (Hep-2, HeLa, A-549, HT-29 and A-375) and in non-tumor (HEK-293 and MRC-5), showed selectivity for tumor cell lines. Immunocytochemistry presenting a majority of tumor cells at late stages of the apoptotic process and necrosis. Given the results presented here, Brazilian Salvia offi cinalis (L.) used as condiment and tea, may protect the body against some disease, in particularly those where oxidative stress is involved, like neurodegenerative disorders, infl ammation and cancer.

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Section: Discussionmentioning

confidence: 99%

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Garcia

Menti

Lambert

et al. 2016

An. Acad. Bras. Ciênc.

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“…ROS, mainly, H 2 O 2 , can oxidize and inhibit PTEN, which culminates in an increase in the PIP3 production, that acts in cell signaling, through activation of proteins, as serine/threonine protein kinase, AKT/PKB, among others [120,121]. The AKT activation provides the transcription of several targets, such as GSK3, BAD, FOXO, p53, NF-kB, mTOR/p70S6K1 and HIF-1 [122,123]. In this way, ROS increase the final cascade response in cell, i.e., cell cycle progression, proliferation, anti-apoptosis, invasion, autophagy and angiogenesis [124].…”

Section: Some Ros Such As Omentioning

confidence: 99%

Oxidative Stress: Noxious but Also Vital

Bagatini¹,

Jaques²,

Oliveira³

et al. 2018

Novel Prospects in Oxidative and Nitrosative Stress

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The imbalance between reactive oxygen species (ROS) production and antioxidant defenses determines the condition called oxidative stress. When there is an increase in ROS production or a decrease in the antioxidant defenses, this systemic antioxidant/pro-oxidant imbalance may lead to the accumulation of oxidative damage, which, in turn, may lead to a modification of biomolecules. These consist of reactions resulting in protein adducts, DNA oxidation, and formation of lipid peroxides, which, in turn, reduce the cellular functional capacity and increase the risk of disease development. The body has natural scavenging systems against free radicals and other reactive species. However, sometimes the endogenous antioxidant capacity is exceeded by the production of ROS. When this occurs, exogenous antioxidants exert important function for the human health. These bioactive compounds act preventing and neutralizing the formation of new reactive species and free radical s .I ns o m ec a s e s ,a n increase of ROS can help the host to resolve an infection or even to control the tumor growth. Finally, the levels of ROS can be perceived by signal transduction pathways involving known targets(i.e.,p53,Ras,andNF-κB) and regulate physiopathological events such as the cellular cycle, apoptosis, and inflammation.Keywords: reactive species, cellular oxidation, antioxidant system, health, disease © 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cellular respiration and generation of reactive species in the mitochondria: implications in cell viability and agingOxidative phosphorylation is the center of energy metabolism in plants, animals and several microbial life forms [1]. In eukaryotes, this process occurs in mitochondria. The mitochondria is a cytoplasmic organelle surrounded by two membranes, outer and inner membrane, which main function is the production of most of the phosphate compounds necessary for the energetic balance of the cell. In addition, other functions such as the regulation of the body'sheatgeneration [2][3][4] programmed cell death [5][6][7], reactive oxygen species (ROS) generation and cell signaling [8] is also associated with mitochondria. Cellular vitality is directly related to mitochondria, and mitochondrial dysfunctions are frequent causes of accidental cell death [5,[9][10][11], cancer [12, 13], diabetes [14][15][16] and neurodegenerative diseases [17][18][19], among others.The characterization of the respiratory electron chain could be performed in studies using the fractionation of its components by certain detergents that at low concentrations break the interactions between proteins and lipids in the membranes, leaving associations between proteins intact [20]. In electron transport chain, through this process, four protein complexes were found....

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“…Consequently, investigators have focused on anticancer constituents in supercritical CO 2 extracts. Accumulating evidence suggests that these extracts have several possible anticancer agents, including caryophyllene oxide (Park et al, 2011), β-caryophyllene (Jun et al, 2011), limonene (Crowell et al, 1994), nobiletin (Yoshimizu et al, 2004), tangeretin (Chaumontet et al, 1997), squalene (Reddy et al, 2009), hexadecanoic acid (Ji et al, 2005, (Z)-9-octadecenoic acid (Cury-Boaventura et al, 2004), alpha-terpineol (Hassan et al, 2010), and γ-sitosterol (Khan and Mlungwana, 1999). Additionally, phytosterols were also detected in comparatively good amounts (3.34 − 8.48 %).…”

Section: Gc-ms Analysis Chromatographic Analysis Was Carried Out Usinmentioning

confidence: 99%

“…Citrus fruits, citrus fruit extracts, essential oils, and flavonoids exhibit a wide range of promising biological properties including anticancer activity (Jayaprakasha et al, 2008;Ejaz et al, 2006). Although several compounds are unique to citrus and are relatively rare in other plants, their individual components have also demonstrated anticancer activity against different cell lines (Park et al, 2011, Crowell et al, 1994Murakami et al, 1997;Yoshimizu et al, 2004;Chaumontet et al, 1997). Some studies have summarized a bibliography of citrus component studies and their potential uses as remedies for treating many infectious diseases and as cancer chemo-preventive agents (Manners, 2007;Ou, 1999).…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antiproliferative Activity of Supercritical CO2 Extracts from Citrus Fruits

Gyawali

Moon

Jeon

et al. 2012

FSTR

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Supercritical CO 2 extract from fruits of Citrus hassaku Hort ex Tanaka, Citrus iyo Hort. ex Tanaka, and Citrus grandis Osbeck, locally known as phalsak, yeagam, and dangyuja, respectively, in Korea, were analyzed by gas chromatography-mass spectrometry (GC-MS). In total, 70, 79, and 76 compounds were identified in fruits of phalsak, yeagam, and dangyuja respectively. (Z)-9-Octadecenoic acid was the major compound in phalsak, whereas limonene prevailed among the others. α-Terpineol, (E,E)-2,4-decadienal, hexadecanoic acid, pentacosane, stigmasterol, and γ-sitosterol were prominent in all species. Antiproliferative activity of the fruit extract was revealed through the colorimetric MTT (tetrazolium) assay against human glioblastoma U373MG, SNU-16 gastric cancer cells, HeLa cervix adenocarcinoma cells and AGS gastric adenocarcinoma cells. Although all tested fruit extracts exhibited antiproliferative effects toward cancer cells, different cell lines varied in their sensitivity to the same plant fruit extract.

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β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation

Cited by 310 publications

References 50 publications

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells

Oxidative Stress: Noxious but Also Vital

Chemical Composition and Antiproliferative Activity of Supercritical CO2 Extracts from Citrus Fruits

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