β-Carotene suppresses osteoclastogenesis and bone resorption by suppressing NF-κB signaling pathway

Wang, Rui; Wang, Nan; Gao, You-Shui; Zhou, Zubin; Liu, Wei; Pan, Cunhong; Yin, Peng; Yu, Xiaowei; Tang, Mingjie

doi:10.1016/j.lfs.2017.03.002

Cited by 41 publications

(41 citation statements)

References 27 publications

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“…RARs attach to DNA as heterodimers with the retinoid X receptors (RXRs) and consequently modulate retinoic acid-responsive target genes. 28,[39][40][41] Wang et al 2 reported that b-carotene exerted an inhibitory effect on osteoclastogenesis and resorption pit formation through the nuclear factor-kappa B (NF-kB) pathway. To study the osteoinductive effect of b-carotene-containing mats on the differentiation of MSCs, scaffolds (PCL/bC2% and PCL/bC4%, 0.5 Â 0.5 cm 2 ) were seeded with cells (10 4 cell per well) and kept in DMEM with 10% FBS as a non-differential medium for up to 21 days.…”

Section: Osteoblast Differentiationmentioning

confidence: 99%

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

et al. 2018

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Section: Osteoblast Differentiationmentioning

confidence: 99%

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

et al. 2018

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“…The mechanism involved in the protective effect of β-carotene and β-cryptoxanthin on bone mass has been investigated in several studies both in vivo [ 26 , 36 , 37 ] and in vitro [ 24 , 25 , 38 ]. Several studies have suggested that β-carotene [ 25 ] and β-cryptoxanthin [ 26 ] may have an inhibitory effect on bone resorption, due to their antioxidative activities. Wang et al, reported that β-carotene can suppress osteoclastogenesis and bone resorption, by suppressing the receptor activator of nuclear factor kappa-B ligand (RANKL) signaling pathway [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, some cross-sectional [ 19 , 20 ] and longitudinal [ 21 , 22 ] studies have demonstrated that antioxidant carotenoids, abundant in fruits and vegetables [ 23 ], are beneficial for the maintenance of normal bone metabolism in post-menopausal women (30–70 years), men and women (2–62 years), and also men (4–74 years). Several potential mechanisms have been proposed to explain the correlation between carotenoids and bone health, including an inhibitory effect of carotenoids on osteoclastic bone resorption related to their antioxidant activity [ 24 , 25 ] and their stimulatory effect on osteoblastic bone formation [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Dietary Carotenoid Intake and Bone Mineral Density in Korean Adults Aged 30–75 Years Using Data from the Fourth and Fifth Korean National Health and Nutrition Examination Surveys (2008–2011)

Regu

Kim

et al. 2017

Nutrients

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Age-related bone loss is a major public health problem. This cross-sectional study examined the association between the dietary intake of carotenoids and bone mineral density (BMD). Data from 8022 subjects (3763 males and 4259 females) aged 30–75 years included in the Korean National Health and Nutrition Examination Survey (2008–2011) were analyzed. BMD was measured by dual-energy X-ray absorptiometry. Intake of carotenoids was estimated using 24-h dietary recall. In multiple linear analysis, after adjusting for covariates, lutein + zeaxanthin and β-cryptoxanthin intake was positively associated with total hip BMD in males and premenopausal women respectively, while β-carotene intake was positively correlated with femoral neck, total hip, and whole-body BMD in postmenopausal women. Postmenopausal women in the highest quintile of daily β-carotene intake, showed a lower risk of osteopenia at the lumbar spine (odds ratio (OR): 0.35, 95% CI: 0.16–0.79, P for trend = 0.009) than those in the lowest quintile, after adjusting for covariates. Daily β-cryptoxanthin intake was significantly associated with a lower risk of osteopenia at the total hip (OR per 1 mg/day increase: 0.76; 95% CI: 0.59–0.97), and lumbar spine (OR per 1 mg/day increase: 0.79; 95% CI: 0.70–0.89) in postmenopausal women. These results suggest that the dietary intake of β-carotene and β-cryptoxanthin may have a positive effect on bone health.

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“…Therefore, antioxidant β-carotene may have a bene cial effect against oxidative stress related to osteoporosis. β-carotene enhances osteoclastogenesis and reduces osteoblast apoptosis by stabilizing the βcatenin signaling pathway, which leads to a decrease in bone resorption [51][52][53]. In addition, carotenoids may interfere with growth factor receptor signaling by regulating IGF-1/IGFBP3, which are associated with cognitive function [54].…”

Section: Discussionmentioning

confidence: 99%

Effects of β-carotene intake on the risk of fracture: A Bayesian meta-analysis

Charkos

Liu

Oumer

et al. 2020

Preprint

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Background: Epidemiological studies examining the association between β-carotene intake and risk of fracture has reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture using a Bayesian approach. Methods: We systematically searched PubMed, EMBASE and Cochrane library databases for relevant articles that were published until December 2019. We also identified studies from reference lists of articles identified from the clinical databases. The Bayesian random-effects model was used to synthesize data from individual studies. Results: Nine studies with a total of 190,545 men and women, with an average age of 59.8 years, were included in this meta-analysis. For β-carotene intake, the pooled risk ratio (RR) of any fracture was 0.67 (95% Credible Interval (CrI): 0.51-0.82; heterogeneity: P = 0.66, I2 =0.00 %) and 0.63 (95%CrI: 0.44-0. 82) for hip fracture. By study design, the pooled RRs were 0.55 (95% CrI: 0.14-0.96) for case-control studies and 0.82 (95% CrI: 0.58-0.99) for cohort studies. By geographic region, the pooled RRs were 0.58 (95% CrI: 0.28-0.89) for studies conducted in China, and 0.86 (95% CrI: 0.35-0.1.37) 0.91(95% CrI: 0.75-1.00) for studies conducted in the United States and Europe, respectively. By gender, the pooled RRs were 0.88 (95% CrI: 0.73-0.99) for males and 0.76 (95% CrI: 0.44-1.07) for females. There was a 95% probability that β-carotene intake reduces risk of hip fracture and any type of fracture by more than 20%. Conclusions: The present meta-analysis suggests that β-carotene intake was inversely associated with fracture risk, which was consistently observed for case-control and cohort studies. Randomized controlled trials are warranted to confirm this relationship.

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β-Carotene suppresses osteoclastogenesis and bone resorption by suppressing NF-κB signaling pathway

Cited by 41 publications

References 27 publications

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

β-Carotene: a natural osteogen to fabricate osteoinductive electrospun scaffolds

Association between Dietary Carotenoid Intake and Bone Mineral Density in Korean Adults Aged 30–75 Years Using Data from the Fourth and Fifth Korean National Health and Nutrition Examination Surveys (2008–2011)

Effects of β-carotene intake on the risk of fracture: A Bayesian meta-analysis

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