β-Carotene supplementation ameliorates experimental liver fibrogenesis via restoring antioxidant status and hepatic stellate cells activity

Latief, Uzma; Husain, Hadiya; Ahmad, Riaz

doi:10.1016/j.jff.2018.08.027

Cited by 13 publications

(5 citation statements)

References 61 publications

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“…However, the results from the group fed a diet with buriti oil (BFe) suggest that the oil chemical composition was efficient to minimize the deleterious effect of the high-FeSO 4 dose on antioxidant enzyme activity. This result agrees with studies in which GPx and SOD activity evaluation in animals and humans with a β-carotene- or α-tocopherol-supplemented diet indicated the expression and activity of these enzymes, probably because of the compensatory defense of oxidative stress [ 64 , 65 , 66 , 67 ].…”

Section: Discussionsupporting

confidence: 91%

“…The high contents of β-carotene and α-tocopherol quantified in buriti oil contribute to the significant in vitro antioxidant capacity, which in turn can attenuate oxidative damage with consequent tissue recovery and biomolecules. β-carotene can quench singlet oxygen, α-tocopherol reduces mitochondrial hydrogen peroxide release rate, and both react as ROS scavengers in a nonenzymatic manner to prevent or decrease oxidative damage to biomolecules and cells [ 50 , 65 , 66 , 67 , 68 ]. Furthermore, a previous study demonstrated the synergism action among oleic acid and α-tocopherol to prevent oxidative stress [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and Lipid-Lowering Effects of Buriti Oil (Mauritia flexuosa L.) Administered to Iron-Overloaded Rats

et al. 2023

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The indiscriminate use of oral ferrous sulfate (FeSO4) doses induces significant oxidative damage to health. However, carotene-rich foods such as buriti oil can help the endogenous antioxidant defense and still maintain other body functions. This study aimed to assess the effects of buriti oil intake in iron-overloaded rats by FeSO4 administration. Buriti oil has β-carotene (787.05 mg/kg), α-tocopherol (689.02 mg/kg), and a predominance of monounsaturated fatty acids (91.30 g/100 g). Wistar rats (n = 32) were subdivided into two control groups that were fed a diet containing either soybean or buriti oil; and two groups which received a high daily oral dose of FeSO4 (60 mg/kg body weight) and fed a diet containing either soybean (SFe) or buriti oil (Bfe). The somatic and hematological parameters, serum lipids, superoxide dismutase (SOD), and glutathione peroxidase (GPx) were determined after 17 days of iron overload. Somatic parameters were similar among groups. BFe showed a decrease in low-density lipoprotein (38.43%) and hemoglobin (7.51%); an increase in monocytes (50.98%), SOD activity in serum (87.16%), and liver (645.50%) hepatic GPx (1017.82%); and maintained serum GPx compared to SFe. Buriti oil showed systemic and hepatic antioxidant protection in iron-overloaded rats, which may be related to its high carotenoid, tocopherol, and fatty acid profile.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Antioxidant and Lipid-Lowering Effects of Buriti Oil (Mauritia flexuosa L.) Administered to Iron-Overloaded Rats

et al. 2023

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“…5 ) provided clear evidence of organ toxicity, similar to those associated with known hepatotoxins and nephrotoxins. 52 , 54 , 55 , 56 It also provided the much needed correlation with observed changes in biochemical indices ( Table 3 ). However, differences in liver and kidney histology do not seem to follow a specific pattern for both single and 28 days of repeated doses.…”

Section: Discussionmentioning

confidence: 97%

Biochemical, hematological and histopathological evaluation of the toxicity potential of the leaf extract of Stachytarpheta cayennensis in rats

Olayode

Daniyan

Olayiwola

2020

Journal of Traditional and Complementary Medicine

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Background and Aim The many pharmacological potentials of Stachytarpheta cayennensis (L.C. Rich) Vahl, especially in managing central nervous system disorders, hypertension, diabetes and infections, have made it a subject of abuse, necessitating the need to ascertain its safety. This study therefore investigated the toxic effects of the leaf extract of S. cayennensis in rats following acute and 28-day repeated doses in male and female rats. Experimental procedure Acute and repeated dose studies were conducted in male and female groups of rats (135–150 g), using OECD 423 and 407 Tests guidelines respectively. Functional observational battery, and body weights were monitored. Blood samples were analysed for haematological and plasma biochemical indices. Organs (brain, kidneys and liver) specimen were collected and weighed. Kidney and liver specimen were subjected to histopathological analysis. Results and conclusion The LD 50 of the extract was greater than 5000 mg/kg, p.o. (24 h) suggesting that the extract may be non-toxic. However, following single and repeated doses, the results revealed varying degree of significant (p < 0.05) changes in biochemical and heamatological indices, as well as in relative body weight and organ-body and organ-brain weight ratios. Also, histological assessment revealed evidence of liver and kidney toxicities and recovery was incomplete, as signs of toxicities were still evident after 21 days of recovery. Therefore, the extract is potentially harmful to vital organs with evidence of sex differential adverse effects and non-reversible forms of toxicity, especially with repeated usage, necessitating the need to avoid indiscriminate use.

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“…Yapılan in vivo çalışmalar DEN'in çeşitli derecelerde hepatik hasarlara neden olduğunu göstermektedir (4,6,20). Lipit peroksidasyonunun bir belirteci olan MDA'nın DEN uygulaması ile deney hayvanlarının karaciğer dokularındaki miktarının yükseldiği çeşitli çalışmalarla gösterilmiştir (21,22). Mevcut çalışmada da bu bilgilere paralel olarak, DEN uygulamasına maruz bırakılan tavşanların serum örneklerinde MDA miktarlarının yaklaşık 4,7 kat artış gösterdiği, ancak bu artışın zamana bağlı olarak trendini bozmadığı görülmüştür.…”

Section: Tartişma Ve Sonuçunclassified

“…β-karoten'in de DEN aracılı hepatik hasarlara karşı koruyucu etkilerinin olabileceği Latief ve ark. (22) tarafından yapılan çalışmada ortaya konulmuştur. Sunulan çalışmada elde edilen veriler ise β-karoten'in, DEN aracılı meydana gelen serum MDA artışını ilk gün önemli ölçüde azalttığını, ancak β-karoten takviyesinin devam etmesine karşın, bu etkinin ilerleyen günlerdeki MDA miktarlarına yansımadığını göstermektedir.…”

Section: Tartişma Ve Sonuçunclassified

Dietilnitrozamin ile İndüklenen Tavşanlarda β-Karotenin Nitrik Oksit ve Malondialdehit Düzeylerine Etkisinin Araştırılması

Merkit

Merhan

2021

Dicle Üniversitesi Veteriner Fakültesi Dergisi

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Asidik ortamda nitroz aside dönüşen nitritler, karsinojenik etkiye sahip N-nitrozo bileşiklerinin prekürsorüdür. Sekonder yapılı aminler, nitroz asitle reaksiyona girerek nitrozamin bileşiklerini oluştururlar. Doğada yaygın olarak bulunan nitrozaminler karsinojenik bileşiklerdir. Bazı kozmetik, pestisit ve çoğu kauçuk ürünlerin imalatında kullanılan nitrozaminler; lateks ürünlerinde, tahıl, çay, birçok gıdada, sigara ve sigara dumanında bulunur. Dietilnitrozamin (DEN) ise nitrozaminlerin en bilindik üyesidir ve hepatik karsinoma neden olabilmektedir (1). Bu yönüyle DEN güncel olarak deneysel karaciğer kanseri oluşturmak için kullanılan kanserojenik ajanlardan biridir (2). Karaciğerde metabolize edildiğinde DNA alkilasyonuna ve oksidatif strese neden olarak kanserojenik etki göstermesi nedeniyle DEN'in erken dönem kanserojenik etkileri, doku ve plazma düzeyinde serbest radikal artışı ve lipit peroksidasyonunun indüksiyonu ile izlenebilmektedir (3-6).

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β-Carotene supplementation ameliorates experimental liver fibrogenesis via restoring antioxidant status and hepatic stellate cells activity

Cited by 13 publications

References 61 publications

Antioxidant and Lipid-Lowering Effects of Buriti Oil (Mauritia flexuosa L.) Administered to Iron-Overloaded Rats

Antioxidant and Lipid-Lowering Effects of Buriti Oil (Mauritia flexuosa L.) Administered to Iron-Overloaded Rats

Biochemical, hematological and histopathological evaluation of the toxicity potential of the leaf extract of Stachytarpheta cayennensis in rats

Dietilnitrozamin ile İndüklenen Tavşanlarda β-Karotenin Nitrik Oksit ve Malondialdehit Düzeylerine Etkisinin Araştırılması

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