β-Blocker Compliance, Mortality, and Reinfarction: Validation of Clinical Trial Association Using Insurer Claims Data

Kleiner, Samuel; Vogt, William B.; Gladowski, Patricia; DeVries, Andrea; Levin, G.; Antonucci, Christopher; Fong, John

doi:10.1177/1062860609345003

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…Our findings are generally consistent with previous research (ie, references [16][17][18][19][20][21], yet they reinforce the available evidence because they answer the concerns that had been raised over residual confounding and the "critical need for better studies with healthy user controls." 5 This appears particularly opportune at a moment when the importance of nonadherence to prescription medication is increasingly recognized 4 and payers and purchasers are starting to apply large resources toward adherence improvement.…”

Section: Discussionsupporting

confidence: 90%

Self‐Controlled Case‐Series Study to Verify the Effect of Adherence to Beta‐Blockers in Secondary Prevention of Myocardial Infarction

Bartolomeo

Marino

Guastaroba

et al. 2015

JAHA

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Section: Discussionsupporting

confidence: 90%

Self‐Controlled Case‐Series Study to Verify the Effect of Adherence to Beta‐Blockers in Secondary Prevention of Myocardial Infarction

Bartolomeo

Marino

Guastaroba

et al. 2015

JAHA

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“…After a screening of the full‐text articles, 26 studies did not meet the selection criteria and were excluded (the detailed reason was listed in Figure 1 ). Finally, 18 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 prospective studies comprising 402 201 participants were considered potentially eligible and were included in the exposure‐effect analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 23 , 25 , 26 , 27 , 28 studies with available data on all‐cause mortality outcomes. Statin adherence was the most commonly studied ( n = 13).…”

Section: Resultsmentioning

confidence: 99%

Adherence with cardiovascular medications and the outcomes in patients with coronary arterial disease: “Real‐world” evidence

Chen

et al. 2022

Clinical Cardiology

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Background Cardiovascular medications are vital for the secondary prevention of coronary arterial disease (CAD). However, the effect of cardiovascular medication may depend on the optimal adherence of the patients. This meta‐analysis aims to determine the magnitude of adherence to vascular medications that influences the absolute and relative risks (RRs) of mortality in patients with CAD in real‐world settings. Methods The Cochrane Library, PubMed, and EMBASE databases were searched through March 1, 2022. Prospective studies reporting association as RR and 95% confidence interval between cardiovascular medication adherence and any cardiovascular events and/or all‐cause mortality in patients with CAD were included. A one‐stage robust error meta‐regression method was used to summarize the dose‐specific relationships. Results A total of 18 studies were included. There is a significant inverse linear association between cardiovascular medication adherence and cardiovascular events (pnonlinearity = .68) or mortality (pnonlinearity = .82). The exposure‐effect analysis showed that an improvement of 20% cardiovascular medication adherence was associated with 8% or 12% lower risk of any cardiovascular events or mortality, respectively. In subgroup analysis, the benefit was observed in adherence of stain (RR: 0.90, for cardiovascular events, RR: 0.85, for mortality), angiotensin‐converting enzyme inhibitors (ACEI)/angiotensin II receptor blockers (ARB)(RR: 0.90, for mortality), and antiplatelet agent (RR: 0.89 for mortality) but not in beta‐blocker (RR: 0.90, p = .14, for cardiovascular events, RR: 0.97, p = .32 for mortality). Estimated absolute differences per 1 million individuals per year for mortality associated with 20% improvement were 175 cases for statin, 129 cases for antiplatelet, and 117 cases for ACEI/ARB. Conclusion Evidence from the real word showed poor adherence to vascular medications contributes to a considerable proportion of all cardiovascular disease events and mortality in patients with CAD.

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“…Baroreceptor reflex control of heart rate is also blunted or resetting in these patients [5-8]. β-blockers are often prescribed for the treatment of patients with chronic heart failure [9] and myocardial infarction [10,11]. …”

Section: Introductionmentioning

confidence: 99%

High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats

et al. 2010

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Perinatal taurine depletion and high sugar diets blunted baroreflex function and heightens sympathetic nerve activity in adult rats. Cardiac ischemia/reperfusion also produces these disorders and taurine treatment appears to improve these effects. This study tests the hypothesis that perinatal taurine exposure predisposes recovery from reperfusion injury in rats on either a basal or high sugar diet. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion, TD), 3% taurine (taurine supplementation, TS) or water alone (control, C) from conception to weaning. Male offspring were fed normal rat chow and water containing 5% glucose (G) or water alone (W) throughout the experiment. At 7-8 weeks of age, all rats were anesthetized and their trachea clamped until cardiac arrest occurred and mean arterial pressure fell below 60 mm Hg. The clamp was immediately released and cardiopulmonary resuscitation was performed with cardiac function returning within 4 min. Twenty-four hours later, arterial pressure, heart rate, and baroreflex function were measured in conscious and one day later in anesthetized conditions. Basic blood chemistry and circulating markers of cardiac injury were also measured. Baroreflex sensitivity was depressed moderately in CG and TDW, and severely in TDG. TSW displayed increased baroreflex and high sugar intake returned it to CW. Sympathetic nerve activity increased and parasympathetic decreased in TDW but not TSW and these effects were exacerbated sharply in TDG and slightly in TSG. Arterial pressure and heart rate increased in all groups but to a lesser degree in TDG. Plasma aspartate aminotransferase increased in all groups except TSW, but the increase was nearly 3X greater in TDG vs. any other group. Creatine kinase-MB increased in all groups except TSG and was far greater in TD than other groups. Troponin-T and brain natriuretic peptide were greatly increased in TDG compared to all other groups. Thus, perinatal taurine depletion increases injury from cardiac ischemia/reperfusion, and in adult rats on a high sugar diet, these effects are greatly exacerbated.

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β-Blocker Compliance, Mortality, and Reinfarction: Validation of Clinical Trial Association Using Insurer Claims Data

Cited by 8 publications

References 27 publications

Self‐Controlled Case‐Series Study to Verify the Effect of Adherence to Beta‐Blockers in Secondary Prevention of Myocardial Infarction

Self‐Controlled Case‐Series Study to Verify the Effect of Adherence to Beta‐Blockers in Secondary Prevention of Myocardial Infarction

Adherence with cardiovascular medications and the outcomes in patients with coronary arterial disease: “Real‐world” evidence

High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats

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