2009
DOI: 10.1177/1062860609345003
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β-Blocker Compliance, Mortality, and Reinfarction: Validation of Clinical Trial Association Using Insurer Claims Data

Abstract: Although randomized controlled trials show that long-term beta-blocker use post acute myocardial infarction (AMI) reduces mortality and subsequent cardiovascular events, and that increased compliance lowers mortality, there is limited published research on the effects of long-term beta-blocker compliance in observational community settings. The authors retrospectively study the effect of beta -blocker compliance on mortality and repeat reinfarction using claims records from a major health insurer of all patien… Show more

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Cited by 8 publications
(4 citation statements)
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“…Our findings are generally consistent with previous research (ie, references [16][17][18][19][20][21], yet they reinforce the available evidence because they answer the concerns that had been raised over residual confounding and the "critical need for better studies with healthy user controls." 5 This appears particularly opportune at a moment when the importance of nonadherence to prescription medication is increasingly recognized 4 and payers and purchasers are starting to apply large resources toward adherence improvement.…”
Section: Discussionsupporting
confidence: 90%
“…Our findings are generally consistent with previous research (ie, references [16][17][18][19][20][21], yet they reinforce the available evidence because they answer the concerns that had been raised over residual confounding and the "critical need for better studies with healthy user controls." 5 This appears particularly opportune at a moment when the importance of nonadherence to prescription medication is increasingly recognized 4 and payers and purchasers are starting to apply large resources toward adherence improvement.…”
Section: Discussionsupporting
confidence: 90%
“…After a screening of the full‐text articles, 26 studies did not meet the selection criteria and were excluded (the detailed reason was listed in Figure 1 ). Finally, 18 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 prospective studies comprising 402 201 participants were considered potentially eligible and were included in the exposure‐effect analysis.…”
Section: Resultsmentioning
confidence: 99%
“…Fifteen 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 23 , 25 , 26 , 27 , 28 studies with available data on all‐cause mortality outcomes. Statin adherence was the most commonly studied ( n = 13).…”
Section: Resultsmentioning
confidence: 99%
“…Baroreceptor reflex control of heart rate is also blunted or resetting in these patients [5-8]. β-blockers are often prescribed for the treatment of patients with chronic heart failure [9] and myocardial infarction [10,11]. …”
Section: Introductionmentioning
confidence: 99%